Dr. Krammer received his advanced training in biotechnology and applied virology at the University of Natural Resources and Life Sciences, Vienna (Mentor: Dr. Reingard Grabherr), where he gained extensive experience with expression and purification of recombinant (glyco-) proteins and influenza virus-like particles. He established various expression systems for these proteins using insect cells/baculovirus, mammalian cells, bacteria, yeast and plants. Furthermore, he worked on a novel influenza virus rescue system based on baculovirus transduction of mammalian cells and a novel bioassay to measure inhibition of the influenza virus polymerase complex by cap-snatching inhibitors. He graduated from the University of Natural Resources and Life Sciences, Vienna in 2010.
Dr. Krammer’s post-doctoral work in the laboratory of Dr. Peter Palese at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai, New York focused on the development of broadly neutralizing anti-hemagglutinin stalk antibodies and the design of an universal influenza virus vaccine. The results of these studies have been very promising: After successful testing in animal models (mice, ferrets), studies with this universal influenza virus vaccine are now advancing to human clinical trials.
Currently Dr. Krammer holds a position as an Associate Professor at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. He has published more than 70 papers, is member of the editorial boards of the Journal of Virology, Plos One and Heliyon and is a peer reviewer for more than 30 journals. Dr. Krammer is also member of the Vaccine and Edward Jenner Society Young Investigator Program. In addition he is a scientific adviser for enGenes and PathSensors.
The Krammer laboratory – which is part of the NIH-funded Centers for Excellence in Influenza Research and Surveillance (CEIRS) – focuses on understanding broadly-reactive immune responses against the surface glycoproteins of RNA viruses such as influenza with the goal to develop better vaccines and novel therapeutics.
2014-2017: Member of the Vaccine and Edward Jenner Vaccine Society Young Investigator Program (YIP)
2014: ESWI Young Scientist Travel Award and ‘Young Scientist Co-Chair’
2013: Options for the Control of Influenza VIII Promising Investigator Scholarship
2013: American Society for Virology 32nd Annual Meeting Postdoctoral Travel Award
2012: Centers of Excellence in Influenza Research and Surveillance (CEIRS) Training Grant
2011: Erwin Schrödinger Fellowship (Austrian Science Fund/FWF)
2010: INiTS – Innovation into Business Award, First Prize in the category Life Science, Vienna, Austria
(picture credit: Sebastian Krammer)