Publications

For a complete list of publications, please click here.

Publications: 2016
Vedanthan R, Bansilal S, Soto AV, Kovacic JC, Latina J, Jaslow R, Santana M, Gorga E, Kasarskis A, Hajjar R, Schadt EE, Björkegren JL, Fayad ZA, Fuster V. Family-Based Approaches to Cardiovascular Health Promotion. J Am Coll Cardiol. 2016; 67(14): 1725-37.

Wiley B, Kovacic JC, Basnet S, Makoto A, Kini A, Sharma S, Sengupta P. Intraprocedural Transcatheter Aortic Valve Replacement (TAVR) Annulus Sizing Using Three-Dimensional Transesophageal Echocardiology And “The Turnaround Rule”. JACC Cardiovasc Imaging. 2016; 9(2): 213-5.

Talukdar HA, Asl HF, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Björkegren JLM. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Systems. 2016; 2(3): 196-208.

Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D’Escamard V, Kovacic JC, Kwak TH, Hajjar RJ, Park WJ. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. J Am Coll Cardiol. 2016; 67(13): 1556-68.

Santini MP, Forte E, Harvey RP, Kovacic JC. Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development. 2016; 143(8): 1242-1258.

Abgral R, Dweck MR, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Padilla M, Miller M, Lala A, Sanz J, Narula J, Fuster V, Contreras J, Kovacic JC, Fayad ZA. Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease. Accepted for publication, JACC Cardiovasc Imaging., Feb 2016.

Theodoropoulos K, Mennuni MG, Dangas GD, Meelu OA, Bansilal S, Baber U, Sartori S, Kovacic JC, Moreno PR, Sharma SK, Mehran R, Kini AS. Resistant In-Stent Restenosis in the Drug Eluting Stent Era. Accepted for publication, Catheter Cardiovasc Interv., March 2016.

Evrard SM*, Lecce L*, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d’Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Kovacic JC. Endothelial-To-Mesenchymal Transition Is Common In Advanced Atherosclerotic Lesions And Is Associated With Plaque Instability. Nat Commun. 2016 Jun 24;7:11853. doi: 10.1038/ncomms11853. *Equal contribution.

Franzén O,* Ermel R,* Cohain A,* Akers NK, Di Narzo A, Talukdar HA, Asl HF, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Gianarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JLM. Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases: The Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) Study. Science. 2016; 353(6301): 827-30. *Equal contribution.

Publications: 2015
Kovacic JC, Kini A, Banerjee S, Dangas G, Massaro J, Mehran R, Popma J, O’Neill WW, Sharma SK. Patients with 3-vessel Coronary Artery Disease and Impaired Ventricular Function undergoing PCI with Impella 2.5 Hemodynamic Support Have Improved 90 Day Outcomes Compared to Intra-Aortic Balloon Pump: A Sub-Study of The PROTECT II Trial. J Interv Cardiol. 2015; 28: 32-40.

Björkegren JLM, Kovacic JC, Dudley JT, Schadt EE. Genome-wide significant loci—how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol. 2015; 65: 830-845.

Kini AS, Motoyama S, Vengrenyuk Y, Feig JE, Pena J, Baber U, Bhat AM, Moreno P, Kovacic JC, Narula J, Sharma SK. Multimodality intravascular imaging to predict periprocedural myocardial infarction during percutaneous coronary intervention. JACC Cardiovasc Interv. 2015; 8: 937-945.

Sengupta PP, Wiley BM, Basnet S, Rajamanickman A, Kovacic JC, Fischer GW, Kini AS, Sharma SK. Transthoracic Echocardiography Guidance for TAVR Under Monitored Anesthesia Care. JACC Cardiovasc Imaging. 2015; 8(3): 379-80.

Kovacic JC and Fuster V. Cell Therapy For Patients With Acute Myocardial Infarction: The ACCRUEd Evidence to Date. Circ Res. 2015; 116: 1287-1290.

Kovacic JC. Un-locking the Many Secrets of Non-coding RNA. J Am Coll Cardiol. 2015; 65: 2538-2541.

Publications: 2014
Kovacic JC, Castellano JM, Farkouh ME, Fuster V. The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis. Endocrinol Metab Clin North Am. 2014; 43: 41-57.

Kovacic JC, Mehran R, Sweeny J, Li JR, Moreno P, Baber U, Krishnan P, Badimon JJ, Hulot JS, Kini A, Sharma SK. Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel. J Cardiovasc Pharmacol Ther. 2014; 19(2): 201-8.

Roleder T, Kovacic JC, Ali Z, Sharma R, Cristea E, Moreno P, Sharma SK, Narula J, Kini AS. Combined NIRS and IVUS imaging detects vulnerable plaque using a single catheter system: a head-to-head comparison with OCT. EuroIntervention. 2014; 10(3): 303-11.

Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Kovacic JC, Kranias E, Hajjar RJ, Hadri L. Synergistic role of Protein Phosphatase Inhibitor 1 and SERCA2a in the acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells. Circulation. 2014; 129(7): 773-85.

Dangas GD, Maehara A, Evrard SM, Sartori S, Li JR, Chirumamilla AP, Kitabaysahi A, Gukathasan N, Hassanin A, Baber U, Fahy M, Fuster V, Mintz GS, Kovacic JC. Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a 3-dimensional intravascular ultrasound study. Eur Heart J Cardiovasc Imaging. 2014; 15(2): 201-9.

Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Effect of Bortezomib on the Efficacy of AAV9.SERCA2a Treatment to Preserve Cardiac Function in a Rat Pressure-Overload Model of Heart Failure. Gene Ther. 2014; 21(4): 379-86.

Hulot JS, Stillitano F, Salem JE, Kovacic JC, Fuster V, Hajjar RJ. Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2014; 5(1): 1.

Tomey MI, Narula J, Kovacic JC. Year in Review: Advances in Understanding of Plaque Composition and Treatment Options. J Am Coll Cardiol. 2014; 63: 1604-1616.

Cooley C, Nevado J, Mellad J, Yang D, St. Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF-β signaling mediates endothelial to mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med. 2014; 6(227): 227ra34.

Michelis KC, Boehm M, Kovacic JC. New vessel formation in the context of cardiomyocyte regeneration – the role and importance of an adequate perfusing vasculature. Stem Cell Res. 2014; 13: 666-682.

Garcia-Garcia HM, Jang IK, Serruys PW, Kovacic JC, Narula J, Fayad ZA. Imaging Plaques to Predict and Better Manage Patients with Acute Coronary Events. Circ Res. 2014; 114(12): 1904-17

Fuster V and Kovacic JC. Acute Coronary Syndromes: Pathology, Diagnosis, Genetics, Prevention and Treatment – A Compendium Review. Circ Res. 2014; 114(12): 1847-51.

Michelis KC, Olin JW, Kadian-Dodov D, d’Escamard V, Kovacic JC. Coronary Artery Manifestations of Fibromuscular Dysplasia. J Am Coll Cardiol. 2014; 64(10): 1033-1046.

Narula J and Kovacic JC. Putting TCFA in Clinical Perspective. J Am Coll Cardiol. 2014; 64(7): 681-3.

Publications: 2013
Kovacic JC, Mehran R, Sweeny J, Li JR, Moreno P, Baber U, Krishnan P, Badimon JJ, Hulot JS, Kini A, Sharma SK. Clustering of Acute and Subacute Stent Thrombosis Related to the Introduction of Generic Clopidogrel. Journal of cardiovascular pharmacology and therapeutics 2013 Nov;.

Kini A, Yu J, Cohen MG, Mehran R, Baber U, Sartori S, Vlachojannis GJ, Kovacic JC, Pyo R, O’Neill B, Singh V, Jacobs E, Poludasu S, Moreno P, Kim MC, Krishnan P, Sharma SK, Dangas GD. Effect of bivalirudin on aortic valve intervention outcomes study: a two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2013 Nov;.

Ali ZA, Roleder T, Narula J, Mohanty BD, Baber U, Kovacic JC, Mintz GS, Otsuka F, Pan S, Virmani R, Sharma SK, Moreno P, Kini AS. Increased thin-cap neoatheroma and periprocedural myocardial infarction in drug-eluting stent restenosis: multimodality intravascular imaging of drug-eluting and bare-metal stents. Circulation. Cardiovascular interventions 2013 Oct; 6(5).

Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Tarzami ST, Kovacic JC, Kranias E, Hajjar RJ, Hadri L. Synergistic Role of Protein Phosphatase Inhibitor 1 and SERCA2a in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells. Circulation 2013 Nov;.

Kovacic JC, Sharma AB, Roy S, Li JR, Narayan R, Kim DB, Sharma SK, Kini AS. GuideLiner mother-and-child guide catheter extension: a simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions. Journal of interventional cardiology 2013 Aug; 26(4).

Dangas GD, Maehara A, Evrard SM, Sartori S, Li JR, Chirumamilla AP, Nomura-Kitabayashi A, Gukathasan N, Hassanin A, Baber U, Fahy M, Fuster V, Mintz GS, Kovacic JC. Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a three-dimensional intravascular ultrasound study. European heart journal cardiovascular Imaging 2013 Jul;.

Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma’ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a hemogenic program in mouse fibroblasts. Cell stem cell 2013 Aug; 13(2).

Kovacic JC, Limaye AM, Sartori S, Lee P, Patel R, Chandela S, Trost B, Roy S, Harari R, Narechania B, Karajgikar R, Kim MC, Krishnan P, Moreno P, Baber U, Mehran R, Dangas G, Kini AS, Sharma SK. Comparison of six risk scores in patients with triple vessel coronary artery disease undergoing PCI: Competing factors influence mortality, myocardial infarction, and target lesion revascularization. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013 May;.

Wood KC, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT. Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis. Arteriosclerosis, thrombosis, and vascular biology 2013 Aug; 33(8).

Baber U, Bander J, Karajgikar R, Yadav K, Hadi A, Theodoropolous K, Gukathasan N, Roy S, Sayeneni S, Scott SA, Kovacic JC, Yu J, Sartori S, Mehran R, Uribarri J, Badimon JJ, Muntner P, Moreno P, Kini AS, Sharma SK. Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity. Thrombosis and haemostasis 2013 Jul; 110(1).

Kini AS, Baber U, Kovacic JC, Limaye A, Ali ZA, Sweeny J, Maehara A, Mehran R, Dangas G, Mintz GS, Fuster V, Narula J, Sharma SK, Moreno PR. Changes in plaque lipid content after short-term intensive versus standard statin therapy: the YELLOW trial (reduction in yellow plaque by aggressive lipid-lowering therapy). Journal of the American College of Cardiology 2013 Jul; 62(1).

O’Neill B, Singh V, Kini A, Mehran R, Jacobs E, Knopf D, Alfonso CE, Martinez CA, Martinezclark P, O’Neill W, Heldman AW, Yu J, Baber U, Kovacic JC, Dangas G, Sharma S, Sartori S, Cohen MG. The use of vascular closure devices and impact on major bleeding and net adverse clinical events (NACEs) in balloon aortic valvuloplasty: A sub-analysis of the BRAVO study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013 Feb;.

Roleder T, Suh W, Sharma R, Hecht H, Kovacic JC, Narula J, Kini AS. Plaques with high lipid burden: keeping the fat out of the fire. Heart (British Cardiac Society) 2013 Jul; 99(14).

Cubeddu RJ, Palacios IF, Blankenship JC, Horvath SA, Xu K, Kovacic JC, Dangas GD, Witzenbichler B, Guagliumi G, Kornowski R, Dudek D, Stone GW, Mehran R. Outcome of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention during on- versus off-hours (a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial substudy). The American journal of cardiology 2013 Apr; 111(7).

Kovacic JC, Fuster V. Atherosclerotic risk factors, vascular cognitive impairment, and Alzheimer disease. The Mount Sinai journal of medicine, New York; 79(6).

Publications: 2012
Kovacic JC, Lee P, Baber U, Karajgikar R, Evrard SM, Moreno P, Mehran R, Fuster V, Dangas G, Sharma S, Kini A. Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions. Atherosclerosis 2012; 211: 176-82.

Kovacic JC, Mercader N, Torres T, Boehm M, Fuster V. Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition: From Cardiovascular Development to Disease. Circulation 2012; 125: 1795-1808.

Kovacic JC, Mehran R, Karajgikar R, Suleman J, Kim MC, Krishnan P, Dangas G, Sharma SK, Kini A. Female Gender and Clinical Outcomes After Coronary Interventions: Results From a Large Registry. Catheter Cardiovasc Interv. 2012; 80: 514-521.

Kovacic JC, Sharma SK, Kini AS. Bilateral Coronary Ostial Stenoses Post-Bentall Procedure Causing Hemodynamic Collapse and Requiring Mechanical Assist Device Placement: Successful Intervention Using the Szabo Technique. Catheter Cardiovasc Interv. 2012: 79: 801-804.

Chih S, Macdonald PS, McCrohon JA, Ma D, Moore J, Feneley MP, Law M, Kovacic JC, Graham RM. Granulocyte-Colony Stimulating Factor in Angina Patients to Stimulate Neovascularization (GAIN II) Trial: A randomized placebo-controlled crossover study. Heart 2012; 98: 282-90.

Chirumamilla AP, Maehara A, Mintz GS, Mehran R, MD, Kanwal S, Weisz G, Hassanin A, Hakim D, Guo N, Baber U, Pyo R, Moses JW, Fahy M, Kovacic JC, Dangas GD. High Platelet Reactivity on Clopidogrel Therapy Correlates With Increased Coronary Atherosclerosis and Calcification: A Volumetric Intravascular Ultrasound Study. J Am Coll Cardiol Img. 2012; 5: 540-549.

Evrard S, d’Audigier C, Mauge L, Israël-Biet D, Guerin CL, Bieche I, Kovacic JC, Fischer AM, Gaussem P, Smadja DM. Profibrotic cytokine TGF-β1 increases endothelial progenitor cell angiogenic properties. J Thromb Haemost. 2012; 10: 670-679.

Kovacic JC, Castellano JM, Fuster V. Cardiovascular Defense Challenges at the Basic, Clinical and Population Levels. Ann. N.Y. Acad. Sci. 2012; 1254: 1-6.

Kovacic JC, Castellano JM, Fuster V. The Links Between Complex Coronary Disease, Cerebrovascular Disease and Degenerative Brain Disease. Ann. N.Y. Acad. Sci. 2012; 1254: 99-105.

Castellano JM, Kovacic JC, Sanz J, Fuster V. Are We Ignoring the Dilated Thoracic Aorta? Ann. N.Y. Acad. Sci. 2012; 1254: 164–174.

Chinitz JS, Castellano JM, Kovacic JC, Fuster V. Atrial Fibrillation, Stroke and Quality of Life. Ann. N.Y. Acad. Sci. 2012; 1254: 140-150.

Kovacic JC and Fuster VF. Vascular Calcification, Diabetes and Cardiovascular Disease – Connecting the Dots. JACC Cardiovasc Imaging. 2012; 5: 367-369.

Kovacic JC and Fuster VF. Smoking Gun Theory: Angiographically Normal or Mild Coronary Plaque as a Cause of Myocardial Infarction. Circulation 2012; 126: 2918-2920.

Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Saebo K, Tsimikas S, Witztum J, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. Increased Expression of Oxidation-Specific Epitopes and Apoptosis are Haptoglobin Genotype Dependent: Implications for Plaque Progression in Human Atherosclerosis. J Am Coll Cardiol. 2012; 60: 112-119.

Kovacic JC, Lee P, Karajgikar R, Baber U, Narechania B, Suleman J, Moreno PR, Sharma SK, Kini AS. Safety of temporary and permanent suspension of anti-platelet therapy after drug eluting stent implantation in contemporary ‘real-world’ practice. J Interv Cardiol. 2012; 25: 482-92.

Kovacic JC and Fuster VF. Atherosclerotic risk factors, vascular cognitive impairment, and Alzheimer disease. Mt Sinai J Med. 2012; 79: 664-73.

Publications: 2011
Rubboli A, Kovacic JC, Mehran R, Lip GYH. Coronary stent Implantation in patients committed to long-term oral anticoagulation: successfully navigating the treatment options. Chest 2011; 139: 981-987.

Kovacic JC, Moreno P, Hachinski V, Nabel EG, Fuster V. Cellular senescence, vascular disease and aging. Part 1 of a 2-part review: advances at the molecular and cellular level. Circulation 2011; 123: 1650-1660.

Kovacic JC, Moreno P, Nabel EG, Hachinski V, Fuster V. Cellular senescence, vascular disease and aging. Part 2 of a 2-part review: clinical vascular disease in the elderly. Circulation 2011; 123: 1900-1910.

Baber U, Kovacic JC, Kini AS, Sharma SK, Dangas G, Mehran R. How Serious a Problem is Bleeding in Patients with Acute Coronary Syndromes? Current Cardiology Report 2011; 13: 312-319.

Kovacic JC, Fuster V. From treating complex coronary artery disease to promoting cardiovascular health: therapeutic transitions and challenges, 2010-2020. Clin Pharmacol Ther. 2011; 90: 509-518.

Kovacic JC and Kini A. Inferior outcomes in Percutaneous Coronary Interventions: narrowing the gap between men and women. Interv Cardiol. 2011; 3: 119-121.
Kovacic JC and Randolph G. Vascular Calcification: Harder Than It Looks. Arterioscler Thromb Vasc Biol. 2011; 31: 1249-1250.

Baber U, Mehran R, Sharma SK, Brar S, Yu J, Suh JW, Kim HS, Park SJ, Kastrati A, de Waha A, Krishnan P, Moreno P, Sweeny J, Kim MC, Suleman J, Pyo R, Wiley J, Kovacic J, Kini AS, Dangas G. Impact of the Everolimus-Eluting Drug Eluting Stent on Stent Thrombosis: A Meta-Analysis of 13 Randomized Trials involving 17,101 Patients. J Am Coll Cardiol. 2011; 58: 1569-77.