Publications

Selected Publications:

  • Nicholas Chun, Robert Fairchild, Yansui Li, Jinhua Liu, Ming Zhang, William Baldwin III, Peter. S. Heeger. Complement dependence of murine costimulatory blockade-resistant cellular cardiac allograft rejection. Am J Transplantation 17: 2810-2819, 2017
  • Miguel Fribourg, Jie Ni, F. Nina Papavasiliou, Zhenyu Yue, Peter S. Heeger and Jeremy S. Leventhal. Allospecific Memory B Cell Responses are Dependent on Autophagy Am J Transplantation 18:102-112, 2018
  • Joong-Hyuk Sheen, Michael Strainic, Jinbo Lui, Weija Zhang, Zhengzi Yi, M. Edward Medof*, Peter S. Heeger* Toll like receptor-induced murine dendritic cell activation requires dendritic cell-intrinsic complement *co-senior authors J Immunol 199: 278-291, 2017.
  • Divya Verghese, Markus Demir, Nicholas Chun, Miguel Fribourg, Paolo Cravedi, Ines Llaudo, Pragya Yadav Trent M. Woodruff, Sergio Lira, M. Edward Medof and Peter S. Heeger Nicholas Chun, Robert Fairchild, Yansui Li, Jinhua Liu, Ming Zhang, William Baldwin III, Peter. S. Heeger. Complement dependence of murine costimulatory T cell expression of C5a receptor 2 augments murine regulatory T cell generation and regulatory-T-cell-dependent cardiac allograft survival The Journal of Immunology 200:2186-98, 2018.
  • Francesca D’Addio, Andrea Vergani, Luciano Potena, Anna Maestroni, Vera Usuelli, Moufida Ben Nasr, Roberto Bassi, Sara Tezza, Sergio Dellepiane, Basset El Essawy,4,5Maria Iascone, Attilio Iacovoni, Laura Borgese, Kaifeng Liu, Gary Visner, Sirano Dhe-Paganon, Domenico Corradi, Reza Abdi, Randall C. Starling, Franco Folli, Gian Vincenzo Zuccotti, Mohamed H. Sayegh, Peter S. Heeger, Anil Chandraker, Francesco Grigioni,andPaolo Fiorina. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. J Clin Invest. 2018 10.1172/JCI94524
  • Ines Llaudo, Miguel Fribourg, M. Edward Medof, Patricia Conde, Jordi Ochando, Peter S. Heeger. C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival. Am J Transplantation 2018 https://doi.org/10.1111/ajt.15072
  • Ruihua Zhang, Chen-feng Qi, Yuan Hu, Yanhong Shan, Yuan-Pang Hsieh, Feihong X, Geming Lu1, Jun Dai, Monica Gupta, Miao Cui, Liang Peng, Qingjie Xue, Ray Chen-Liang, Kang Chen, Wai-Ping Fung-Leung, J. Rodrigo Mora, Liwu Li, Herbert C. Morse III, Keiko Ozato, Peter S. Heeger, and Huabao Xiong. T Follicular Helper Cells restricted by IRF8 contribute to T Cell-Mediated Inflammation, Journal of Autoimmunity 96: 113-122, 2018
  • Divya A. Verghese, Katelyn Paz, Nicholas Chun, Miguel Fribourg, Trent M. Woodruff, Ryan Flynn, Jing Du, Bruce R. Blazar*, and Peter S. Heeger* co-senior authors. Targeting C5aR1 ameliorates T follicular helper-dependent murine chronic graft-versus-host disease JCI Insight 2018;3(24):e124646. https://doi.org/10.1172/jci.insight.124646.
  • Josef Stehlik, MD, MPH ; Brian Armstrong, MPH ; David A. Baran, MD; Nancy D Bridges, MD; Anil Chandraker, MD, PhD; Robert Gordon, MD; Teresa De Marco, MD7; Michael M. Givertz, MD; Alain Heroux, MD; David Ikle, PhD; Judson Hunt, MD; Abdallah G. Kfoury, MD; Joren C. Madsen, MD, DPhil; Yvonne Morrison; Erika Feller, MD; Sean Pinney, MD; Sudipta Tripathi, PhD,MSc; Peter S Heeger, MD; Randall C Starling, MD, MPH, for the CTOT05/18 Consortium. Early Immune Biomarkers and Intermediate-term Outcomes after Heart Transplant: Results of Clinical Trials in Organ Transplantation-18 Am J Transplantation 2018 Dec 14. doi: 10.1111/ajt.15218. [Epub ahead of print]
  • MD; Sean Pinney, MD; Sudipta Tripathi, PhD,MSc; Peter S Heeger, MD; Randall C Starling, MD, MPH, for the CTOT05/18 Consortium. Early Immune Biomarkers and Intermediate-term Outcomes after Heart Transplant: Results of Clinical Trials in Organ Transplantation-18 Am J Transplantation 2018 Dec 14. doi: 10.1111/ajt.15218. [Epub ahead of print]
  • Miguel Fribourg, Lisa Anderson, Clara Fischman, Chiara Cantarelli, Laura Perin, Gaetano La Manna, Adeeb Rahman, Bryna Burrell, Peter S Heeger, Paolo Cravedi T-cell exhaustion correlates with improved outcomes in kidney transplant recipients Kidney International 2019 (in press)
  • Douglas R. Mathern, Julian Horwitz, Peter S. Heeger. Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival Am J Transplantation 2018 Dec 19. doi: 10.1111/ajt.15222. [Epub ahead of print]

 

Additional Publications:

Douglas R. Mathern and Peter S. Heeger. Molecules Great and Small: the Complement System. Clinical Journal of the American Society of Nephrology 2015.   http://www.ncbi.nlm.nih.gov/pubmed/25568220

Cravedi P, Heeger PS. Complement as a multifaceted modulator of kidney transplant injury. The Journal of Clinical Investigation 2014; 124:2348-2354.  http://www.ncbi.nlm.nih.gov/pubmed/24892709

Wing-hong Kwan, William van der Touw, Estela Paz-Artal, Ming O. Li, Peter S. Heeger. Signaling through C5a Receptor and C3a Receptor Modulates Function of Natural Regulatory T cells in Mice. J Experimental Medicine 210: 257-68, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23382542

Jessica Reid-Adam, Nan Yang, Ying Song, Paolo Cravedi, Xiu-Min Li, Peter Heeger.  Immunosuppressive Effects of the Traditional Chinese Herb Qu Mai on Human Alloreactive T Cells Amer. J Transplantation 13:1159-67, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23433080

I. Ashoor, N. Najafian, Y. Korin, E. Reed, T. Mohanakumar, D. Ikle, P.S. Heeger,  M. Lin. Standardization and Cross Validation of alloreactive IFNg ELISPOT assays within the Clinical Trials in Organ Transplantation Consortium Amer. J Transplantation 13:1871-9, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23710568

Donald E. Hricik, Emilio D. Poggio, Kenneth J. Woodside, Naragaju Sarabu, Edmund Q. Sanchez, James A. Schulak, Aparna Padiyar, Peter S. Heeger, Joshua J. Augustine Effects of Cellular Sensitization and Donor Age on Acute Rejection and Graft Function after Deceased Donor Kidney Transplantation. Transplantation 95:1254-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23603792

Elaine F. Reed, Ping Rao, Zilu Zhang, Howard Gebel, Robert A Bray, Indira Guleria, John Lunz, Thalachallour Mohanakumar, Peter Nickerson, Anat R Tambur, Adriana Zeevi, Peter Heeger,  David Gjertson. Comprehensive Assessment and Standardization of solid phase multiplex Platforms for the Detection of antibodies to HLA. Amer J of Transplantation 13:1859-70, 2013.   http://www.ncbi.nlm.nih.gov/pubmed/24103158

Donald E. Hricik, Peter Nickerson, Richard N. Formica, Emilio Poggio, David Rush, Kenneth A. Newell, Jens Goebel, Ian W. Gibson, Robert Fairchild, Michael Riggs, David Ikle, Nancy D. Bridges, and Peter S. Heeger  (for the CTOT-01 consortium). Multicenter Validation of Urinary CXCL9 as a Risk-Stratifying Biomarker for Kidney Transplant Injury. Am J Transplant 2013;13:2634-2644.   http://www.ncbi.nlm.nih.gov/pubmed/23968332

Karen S. Keslar, Marvin Lin, Anna A. Zmijewska, Tara K. Sigdeld, , Tim Q. Trand,h, Lingzhi Ma, Manoj Bhasin, Ping Rao, Ruchuang Ding, David N. Iklé, Roslyn B. Mannon, Minnie M. Sarwal, Terry Strom, Elaine F. Reed, Peter S.Heeger,  Manikkam Suthanthiran, and Robert L. Fairchild. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Amer J Transplantation 13: 1891-7, 2013 http://www.ncbi.nlm.nih.gov/pubmed/23802725

Manikkam Suthanthiran, M.D., Joseph E. Schwartz, Ph.D., Ruchuang Ding, M.D., Michael Abecassis, M.D., Ph.D., Darshana Dadhania, M.D., M.S., Benjamin Samstein, M.D., Stuart J. Knechtle, M.D., John Friedewald, M.D., Yolanda T. Becker, M.D., Vijay K. Sharma, Ph.D., Nikki M. Williams, B.S., Christina S. Chang, B.S., Christine Hoang B.S., Thangamani Muthukumar, M.D., Phyllis August, M.D., M.P.H., Karen S. Keslar, M.S., Robert L. Fairchild, Ph.D., Donald Hricik, M.D., Peter S. Heeger, M.D., Leiya Han, M.D., M.P.H., M.S., Jun Liu, Ph.D., Michael Riggs, Ph.D., M.P.H., David N. Ikle, Ph.D., Nancy Bridges, M.D., and Abraham Shaked, M.D., Ph.D. The CTOT-04 Study Investigators† Urinary Cell mRNA Profiles and Acute Cellular Rejection in the Kidney Allograft: The CTOT-04 Study. New England Journal of Medicine 369: 20-31, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23822777

William van der Touw, Paolo Cravedi, Wing-hong Kwan, Estela Paz-Artal, Miriam Merad, Peter S. Heeger. Cutting Edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. Journal of Immunology 190: 5921-5, 2013. *co-first authors.  http://www.ncbi.nlm.nih.gov/pubmed/23690475

Cravedi P, Lessman DA, Heeger PS. Eosinophils are not required for the induction and maintenance of an alloantibody response. Am J Transplant 2013;13:2696-2702. http://www.ncbi.nlm.nih.gov/pubmed/23919628

Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS. Immune cell-derived c3a and c5a costimulate human T cell alloimmunity. Am J Transplant 2013;13:2530-2539. http://www.ncbi.nlm.nih.gov/pubmed/24033923

Kalache S, Lakhani P, Heeger PS. Effects of Preexisting Autoimmunity on Heart Graft Prolongation after Donor-Specific Transfusion and Anti-CD154. Transplantation Transplantation 2014;97:12-19. http://www.ncbi.nlm.nih.gov/pubmed/24056628

Divya Verghese, Peyman Bizargity, Anju Yadav, Barbara Murphy, Peter S. Heeger,  Bernd Schröppel. Costimulatory blockade-induced allograft survival requires Beclin1. Am J Transplant 2014;14:545-553.  http://www.ncbi.nlm.nih.gov/pubmed/24502356

Paolo Cravedi, Joaquin Manrique, Katherine E. Hanlon, Jessica Reid-Adam, Joshua Brody, Praeophayom Prathuangsuk, Anita Mehrotra, Peter S. Heeger. (*co-first authors) Immunosuppressive Effects of Erythropoietin on Human Alloreactive T cells J Am Soc Nephrology, 25: 2003-15, 2014.  http://www.ncbi.nlm.nih.gov/pubmed/24676641

Krassilnikova M, Ostrow K, Bader A, Heeger P, Mehrotra A. Low Dietary Intake of Vitamin D and Vitamin D Deficiency in Hemodialysis Patients, Journal of Nephrology & Therapeutics 2014; 4(3).  http://www.ncbi.nlm.nih.gov/pubmed/25068077

Lily Li, Marvin Lin,  Maria Krassilnikova,  Katya Ostrow, Amanda Bader,  Brian Radbill, Jaime Uribarri,  Joji Tokita, Staci Leisman, Vijay Lapsia,  Randy A. Albrecht,Adolfo García-Sastre,Andrea D. Branch, Peter S. Heeger, Anita Mehrotra.  Effect of Vitamin D Supplementation on Cellular Alloimmunity in Hemodialysis Patients: A Randomized Controlled Trial PLos One epub: October 08, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25296334