The NS1 protein of influenza viruses acts as a virulence factor by inhibiting host immune responses through suppression of the type I IFN system. My research is focused on the viral mechanisms of immune modulation and evasion of influenza viruses, particularly in newly emergent viruses like the influenza A viruses discovered in bats. Using standard reverse genetics techniques, we have generated recombinant influenza viruses in order to address the specific role of the NS1 protein in bat influenza viruses.
Cordero E, Roca-Oporto C, Bulnes-Ramos A, Aydillo T, et al. Two doses of inactivated influenza vaccine improve immune response in solid organ transplant recipients. Results of TRANSGRIPE1-2, a randomised, controlled clinical trial. Clin Infect Dis. 2017 Apr 1;64(7):829-838. doi: 10.1093/cid/ciw855.
Aguiar Moreira E, Locherd S, Kolesnikovae L, Bolte H, Aydillo T, García-Sastre A, Schwemmle M, Zimmer G. Synthetically derived bat influenza A-like viruses reveal cell type- but not species-specific tropism. Proc Natl Acad Sci U S A. 2016 Oct 24.
Turkington HL, Juozapaitis M, Kerry PS, Aydillo T, Ayllon J, García-Sastre A, Schwemmle M, Hale BG. Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity. J Virol. 2015 Oct;89(20):10696-701.
Aydillo T, Pérez-Romero P, Perez-Ordoñez A, et al. Reduced Incidence of Pneumonia in Influenza Vaccinated Solid Organ Transplant Recipients with Influenza Disease. Clin Microbiol Infect. 2012 Dec;18(12):E533-40.
Aydillo T, Cordero E, Perez-Ordoñez A, et al. Deficient Long-term Response to Pandemic Vaccine Results in an Insufficient Antibody Response to Seasonal Influenza Vaccination in SOT-Recipients. Transplantation 2012; Apr 27;93(8):847-54.