Selected Publications
Filipescu D, Carcamo S, Agarwal A, Tung N, Humblin É, Goldberg MS, Vyas NS, Beaumont KG, Demircioglu D, Sridhar S, Ghiraldini FG, Capparelli C, Aplin AE, Salmon H, Sebra R, Kamphorst AO, Merad M, Hasson D, Bernstein E.
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
Nature Cell Biology 2023; 25(9): 1332-1345.
Highlighted in: Nature Cell Biology 'News and Views' (2023): Read here
Ghiraldini FG, Filipescu D, Bernstein E.
Solid tumours hijack the histone variant network.
Nature reviews. Cancer 2021; 21(4): 257-275.
Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, Federico S, Gallego S, Dekio F, Fowkes M, Meni D, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E.
ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.
Cancer Cell 2019; 36(5): 512-527.
Sun Z, Filipescu D, Andrade J, Gaspar-Maia A, Ueberheide B, Bernstein E.
Transcription-associated histone pruning demarcates macroH2A chromatin domains.
Nature Structural & Molecular Biology 2018; 25(10): 958-970.
Strub, T, Ghiraldini, F.G.*, Carcamo, S*, Li, M, Wroblewska, A, Singh, R, Goldberg, MS, Hasson, D, Wang, Z, Gallagher, SJ, Hersey, P, Ma’ayan, A, Long, GV, Scolyer RA, Brown, B, Zheng, B, Bernstein E.
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signaling.
Nature Communications 2018; 9(1): 3440.
Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E.
Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene.
Molecular Cell 2017; 68(4): 731-744.e9.
Chung C-Y, Sun Z, Mullokandov G, , Bosch A, Qadeer ZA, Cihan E, , Rapp Z, Parsons R, Aguirre-Ghiso JA, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E.
Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis.
Cell Reports 2016; 16(2): 472-486.
Valle-Garcia D, Qadeer ZA, McHugh D, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E.
ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment.
Epigenetics 2016; 11(6): 398-414.
Vardabasso C, Gaspar-Maia A, Hasson D, Pünzeler S, Valle-Garcia D, Straub T, Keilhauer EC Strub T, Panda T, Chung C-Y, Dong J, Segura MF, Fontanals-Cirera B, Verma A, Mann M, Hernando E, Hake SB, Bernstein E.
Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma.
Molecular Cell 2015; 59: 75-88.
Highlighted in:
Cancer Discover 'Research Watch' (2015) Read here
Nature Review Cancer (2015) Read here
Duarte LF, Young ARJ, Wang Z, Wu H-A, Panda T, Kou Y, Kapoor A, Hasson D, Mills NR, Ma’ayan A, Narita M, Bernstein E.
Histone H3.3 and its proteolytically processed form drive a cellular senescence program.
Nature Communications 2014; 5:5210.
Highlighted in: Cancer Research, Highlights from Recent Cancer Literature (2014) Read here
Gaspar-Maia A, Qadeer ZA, Ratnakumar K, Hasson D, Leu NA, Leroy G, Liu S, Costanzi C, Schaniel C, Lemischka IR, Garcia BA, Pehrson JR, Bernstein E.
macroH2A histone variants act as a barrier upon reprogramming towards pluripotency.
Nature Communications 2013; 4: 1565.
Contact Us
E-mail
emily.bernstein@mssm.edu
Phone
Tel: 212-824-9335
Lab Address
Department of Oncological Sciences
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1044A
New York, NY 10029
Administrative Assistant
Genevieve Joseph, PhD
Tel: 212-824-9367
E-mail: genevieve.joseph@mssm.edu