Induction of Cardiomyocyte Proliferation Using Cell-Specific Modified
Cardiomyocytes (CMs) proliferation is a key process in myocardial regeneration and may be an effective approach to treat myocardial infarction and heart failure in mammals. Modified mRNA (modRNA) is a safe, efficient, transient, non-immunogenic, controlled, and highly translatable gene delivery system. We have developed a cardiomyocytes-specific, modRNA-based gene delivery method that allows a transient gene expression exclusively in cardiomyocytes.
Enhancing Cell Survival following Myocardial Infarction Using Modified mRNA
The primary aim of the research is to enhance cell survival after myocardial infarction (MI). As a consequences MI, a significant percentage of the heart cells will die and cannot be regenerated. Using Modified RNA encoded with genes known to inhibit apoptosis, we hope to minimize the cardiomyocyte cell death following MI. As a secondary aim, we rare designing a modRNA that can improve the stability and expression of gene in the injured tissue.