![](https://labs.icahn.mssm.edu/yinglab/wp-content/uploads/sites/413/2022/07/V1.jpg)
We study the causal relationship between cancer lesions, environmental cues, tissue damaging stresses and epithelial cell fate choice in homeostasis, malignant growth and tissue regeneration.
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We develop gene targeting systems for rapid large scale gene function tests and high-fidelity lineage tracing assays in both stratified and glandular epithelia.
![](https://labs.icahn.mssm.edu/yinglab/wp-content/uploads/sites/413/2022/07/Figure-S1.jpg)
We are building up the capability of studying high-dimensional combinatorial effect of genetic lesions/signaling pathways using our next-generation lentivirus-based single cell barcoding systems.