We study the causal relationship between cancer lesions, environmental cues, tissue damaging stresses and epithelial cell fate choice in homeostasis, malignant growth and tissue regeneration.

We develop gene targeting systems for rapid large scale gene function tests and high-fidelity lineage tracing assays in both stratified and glandular epithelia.

We are building up the capability of studying high-dimensional combinatorial effect of genetic lesions/signaling pathways using our next-generation lentivirus-based single cell barcoding systems.