Cai, CW; Grey, JA; Hubmacher, D; Han, WM “Biomaterial-Based Regenerative Strategies for Volumetric Muscle Loss: Challenges and Solutions,” Advances in Wound Care, 2024, In Press. 


Fu, C; Chin-Young, B; Park, G; Guzman-Seda, M; Laudier, D; Han, WM “WNT7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis,” Stem Cell Reports, 2023, 18(4):999-1014.

Sayegh, MN; Cooney, KA; Han, WM; Cicka, M; Strobel, F; Wang, L; García, AJ; Levit, RD “Hydrogel Delivery of Purinergic Enzymes Improve Cardiac Ischemia/Reperfusion Injury,” Journal of Molecular and Cellular Cardiology, 2023, 176, 98-109.

Lee, J; Myrie, NO; Jeong, G; Han, WM; Jang, YC*; García, AJ*; Emelianov, S* “In Vivo Shear Wave Elasticity Imaging of Assessment of Diaphragm Function in Muscular Dystrophy,” Acta Biomaterialia, IN PRESS. Equal contribution. *Co-PI.


Fu, C; Guzman-Seda, M; Laudier, D; Han, WM “Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis,” BioRxiv, 2022.


Fu, C; Huang, AH; Galatz, LM; Han, WM “Cellular and Molecular Modulation of Rotator Cuff Muscle Pathophysiology,” Journal of Orthopaedic Research, 2021, 39:2310-2322.

Sayegh, MN; Cooney, KA; Han, WM; Wang, L; Strobel, F; Hansen, LM; García, AJ; Levit, RD “Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion,” Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, ATVBAHA.120.315428.

Mora-Boza, A; Castro, LMM; Schneider, RS; Han, WM; García, AJ; Vázquez-Lasa, B; Román, JS “Microfluidics Generation of Chitosan Microgels Containing Glycerylphytate Crosslinker for In Situ Human Mesenchymal Stem Cells Encapsulation,” Materials Science and Engineering: C, 2021, 120, 111716.


Lee, Y; Choi, JJ; Ahn, SI; Lee, NH; Han, WM; Mohiuddin, M; Shin, EJ; Wood, L; Park, KD; Kim, Y*; Jang, YC* “Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors,” Advanced Functional Materials, 2020, 30(46), 2002924. Equal contribution. *Co-PI.

Cermeño, EA; O’Melia, MJ; Veith, A; Han, WM; Barber, G; Huang, EH; Thomas, SN*; García, AJ* “Hydrodynamic Shear-based Purification of Cancer Cells with Enhanced Tumorigenic Potential,” Integrative Biology, 2020, 12(1), 1-11. *Co-PI.

Clark, AY; Martin, KE; García, JR; Johnson, CT; Han, WM; Zhou, DW; Botchwey, EA; García, AJ “Integrin-specific Hydrogels Modulate Transplanted Human Mesenchymal Stem Cell Survival, Engraftment, and Reparative Activities,” Nature Communications, 2020, 11:114.


Barros, D; Conde-Sousa, E; Han, WM; García, AJ; Amaral, IF*; Pêgo, AP* “Engineering Hydrogels with Affinity-Bound Laminin as 3D Neural Stem Cell Culture Systems,” Biomaterials Science, 2019, 12, 5338-5349. *Co-PI.

García, JR; Quirós, M; Han, WM; O’Leary, MN; Cox, GN; Nusrat, A; García, AJ “IFN-γ-Tethered Hydrogels Enhance Mesenchymal Stem Cell-Based Immunomodulation and Promote Tissue Repair,” Biomaterials, 2019, 220: 119403.

Mohiuddin, M; Lee, NH; Moon, A; Han, WM; Anderson, SE; Choi, JJ; Nakhai, S; Tran, T; Aliya, B; Kim, DY; Gerold, A; Hansen, L; Taylor, WR; Jang, YC “Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Moter Unit and Myonuclear- and Mitochondrial-Domains,” Scientific Reports, 2019, 9(1):9551.

Han, WM; Mohiuddin, M; Anderson, SE; García, AJ*; Jang, YC* “Co-delivery of Wnt7a and Muscle Stem Cells using Synthetic Bioadhesive Hydrogel Enhances Murine Muscle Regeneration and Cell Migration during Engraftment,” Acta Biomaterialia, 2019, 96, 243-252. *Co-PI.

Anderson, SE; Han, WM; Srinivasa, V; Mohiuddin, M; Ruehle, MA; Moon, A; Shin, E; San Emeterio, CL; Ogle, ME; Botchwey, EA; Willett, NJ*; Jang, YC* “Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps,” Tissue Engineering Part C, 2019, 25(2), 59-70. *Co-PI.

Capeling, MM; Czerwinski, M; Huang, S; Tsai, Y-H; Wu, A; Nagy, MS; Juliar, B; Sundaram, N; Song, Y; Han, WM; Takayama, S; Alsberg, E; García, AJ; Helmrath, M; Putnam, AJ; Spence, JR “Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids,” Stem Cell Reports, 2019, 12(2) 381-384.


Han, WM; Anderson, SE; Mohiuddin, M; Barros, D; Nakhai, SA; Shin, E; Amaral, IF; Pêgo, AP; García, AJ*; Jang, YC* “Synthetic Matrix Enhances Transplanted Satellite Cell Engraftment in Dystrophic and Aged Skeletal Muscle with Comorbid Trauma,” Science Advances, 2018, 4:eaar4008. *Co-PI.


Han, WM; Jang, YC; García, AJ “Engineered Matrices for Skeletal Muscle Satellite Cell Engraftment and Function,” Matrix Biology, 2017, 60-61, 96-109.

Aguilar, CA; Pop, R; Shcherbina, A; Watts, A; Matheny Jr., RW; Cacchiarelli, D; Han, WM; Shin, E; Nakhai, SA; Jang, YC; Carrigan, CT; Gifford, CA; Kottke, MA; Cesana, M; Lee, J; Urso, ML; Meissner, A “Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma,” Stem Cell Reports, 2016, 7(5), 983-997.

Heo, SJ; Han, WM; Szczesny, SE; Cosgrove, BD; Elliott, DM; Lee, DA; Duncan, RL; Mauck, RL “Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells,” Biophysical Journal, 2016, 111(4), 864-874.

Han, WM; Heo, SJ; Driscoll, DP; Delucca, JF; McLeod, CM; Smith, LJ; Duncan, RL; Mauck, RL*; Elliott, DM* “Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage,” Nature Materials, 2016, 15(4), 477-484. Equal contribution. *Co-PI.

Han, WM; Heo, SJ; Driscoll, DP; Boggs, ME; Duncan, RL; Mauck, RL; Elliott, DM “Impact of Cellular Microenvironment and Mechanical Perturbation on Calcium Signaling in Meniscus Fibrochondrocytes,” European Cells and Materials Journal, 2014, 27, 321-331.

Han, WM; Heo, SJ; Driscoll, TP; Smith, LJ; Mauck, RL; Elliott, DM “Macro- to Microscale Strain Transfer in Fibrous Tissues is Heterogeneous and Tissue Specific,” Biophysical Journal, 2013, 105(3), 807-817.

Cortes, DH; Han, WM; Smith, LJ; Elliott DM “Mechanical Properties of the Extra-Fibrillar Matrix of Human Annulus Fibrosus are Location and Age Dependent,” Journal of Orthopaedic Research, 2013, 31(11), 1725-1732.

Malhotra, NR; Han, WM; Beckstein J; Cloyd, J; Chen, W; Elliott, DM “An Injectable Nucleus Pulposus Implant to Restore Spinal Range of Motion in Compression,” Spine, 2012, 37(18), E1099-E1105.

Han, WM; Nerurkar, NL; Smith, LJ; Jacobs, NT; Mauck, RL; Elliott, DM “Multi-Scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading,” Annals of Biomedical Engineering, 2012, 40(7), 1610-1621.

Jacobs, NT; Smith, LJ; Han, WM; Morelli, J; Yoder, JH; Elliott, DM “Effect of Orientation and Targeted Extracellular Matrix Degradation on Annulus Fibrosus Shear Mechanical Properties,” Journal of the Mechanical Behavior of Biomedical Materials, 2011, 4(8), 1611-1619.

Nerurkar, NL; Han, W; Mauck, RL; Elliott, DM “Homologous Structure-Function Relationships Between Native Fibrocartilage and Tissue Engineered from MSC-seeded Nanofibrous Scaffolds,” Biomaterials, 2011, 32(2), 461-468.

Book Chapter

Han, W; Jang, YC; García, AJ “The Extracellular Matrix, and Cell-Biomaterial Interactions,” Biomaterials Science, Fourth Edition: An Introduction to Materials in Medicine.


King, MR; Foster, DG; Han, W; Allio, BA “Device And Method For Separation, Concentration, And/Or Purification Of Cells,” U.S. Patent Publication No. US 8399205 B2 (Role: Co-Inventor).

Han, WM; García, AJ; Jang, YC “Synthetic Hydrogel Carriers for Muscle Repair,” Patent Application No. PCT/US2019/042953 (Role: Co-Inventor).

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Han Laboratory
Woojin Han, PhD
Assistant Professor
Department of Orthopaedics

Lab: Annenberg A20-40
Office: Annenberg A20-66A

Phone: 212-241-4507
Email: woojin.han -at-
Twitter: @thewooj

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