At a global scale, mortality due to liver cancer has increased by more than 50% in the last 20 years. It remains as one of the deadliest malignancies with a high ratio of mortality to incidence of 0.95. Since 2012, liver cancer is the second most common cause of death from cancer worldwide. In the US, recent data estimate that in 2014 there will be 33,190 new cases of liver cancer. Overall, patient’s 5-year survival is 16%, which is second worst only behind pancreatic cancer. Altogether, these data confirm that disease burden due to liver cancer is increasing in the US as well as worldwide. The AACR 2013 report confirms how liver cancer has become the leading cause of increased cancer mortality in the last 20 years.