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SARS-CoV-2

SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase.
Srivastava K, Carreño JM, Gleason C, Monahan B, Singh G, Abbad A, Tcheou J, Raskin A, Kleiner G, van Bakel H, Sordillo EM; PARIS Study Group; Krammer F, Simon V.Immunity. 2024 Mar 12;57(3):587-599.e4. doi: 10.1016/j.immuni.2024.01.017. Epub 2024 Feb 22.PMID: 38395697 Free PMC article.

Graphical Abstract:

A surrogate ELISA to select high titer human convalescent plasma for treating immunocompromised patients infected with SARS-CoV-2 variants of concern.
Dolange V, Slamanig S, Abdeljawad A, Ying TL, Lemus N, Singh G, Carreño JM, Abad A, Srivastava K, Simon V, Sachithanandham J, Pekosz A, Sullivan D, Krammer F, Sun W, Palese P, González-Domínguez I.J Infect Dis. 2025 Jan 3:jiae645. doi: 10.1093/infdis/jiae645. Online ahead of print.PMID: 39749487

Nirmatrelvir and molnupiravir maintain potent in vitro and in vivo antiviral activity against circulating SARS-CoV-2 omicron subvariants.
Rosales R, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Diaz-Tapia R, Benjamin J, Rai DK, Cardin RD, Anderson AS; PSP study group; Sordillo EM, van Bakel H, Simon V, García-Sastre A, White KM.Antiviral Res. 2024 Oct;230:105970. doi: 10.1016/j.antiviral.2024.105970. Epub 2024 Jul 25.PMID: 39067667

SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020-2023.
Carreño JM, Wagner AL, Monahan B, Singh G, Floda D, Gonzalez-Reiche AS, Tcheou J, Raskin A, Bielak D, Morris S, Fried M, Yellin T, Sullivan L; PARIS study group; Sordillo EM, Gordon A, van Bakel H, Simon V, Krammer F.Nat Commun. 2024 Jul 11;15(1):5847. doi: 10.1038/s41467-024-50052-2.PMID: 38992013 Free PMC article.

 

Influenza

The immunodominance of antigenic site Sb on the H1 influenza virus hemagglutinin increases with high immunoglobulin titers of the cohorts and with young age, but not sex.
Martínez JL, Lemus N, Lai TY, Mishra M, González-Domínguez I, Puente-Massaguer E, Loganathan M, Francis B, Samanovic MI, Krammer F, Mulligan MJ, Simon V, Palese P, Sun W.Vaccine. 2024 May 22;42(14):3365-3373. doi: 10.1016/j.vaccine.2024.04.037. Epub 2024 Apr 15.PMID: 38627145 Free article.

Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets.
Halwe NJ, Hamberger L, Sehl-Ewert J, Mache C, Schön J, Ulrich L, Calvelage S, Tönnies M, Fuchs J, Bandawane P, Loganathan M, Abbad A, Carreño JM, Bermúdez-González MC, Simon V, Kandeil A, El-Shesheny R, Ali MA, Kayali G, Budt M, Hippenstiel S, Hocke AC, Krammer F, Wolff T, Schwemmle M, Ciminski K, Hoffmann D, Beer M.Nat Commun. 2024 Apr 25;15(1):3450. doi: 10.1038/s41467-024-47455-6.PMID: 38664395 Free PMC article.

 

Mpox

Development of a novel serological assay for the detection of mpox infection in vaccinated populations.
Yates JL, Hunt DT, Kulas KE, Chave KJ, Styer L, Chakravarthi ST, Cai GY, Bermúdez-González MC, Kleiner G, Altman D, Srivastava K; PVI Study Group; Simon V, Feihel D, McGowan J, Hogrefe W, Noone P, Egan C, Slifka MK, Lee WT.J Med Virol. 2023 Oct;95(10):e29134. doi: 10.1002/jmv.29134.PMID: 37805977 Free PMC article.

Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study.
Cohn H, Bloom N, Cai GY, Clark JJ, Tarke A, Bermúdez-González MC, Altman DR, Lugo LA, Lobo FP, Marquez S; PVI study group; Chen JQ, Ren W, Qin L, Yates JL, Hunt DT, Lee WT, Crotty S, Krammer F, Grifoni A, Sette A, Simon V, Coelho CH.Lancet Infect Dis. 2023 Nov;23(11):1302-1312. doi: 10.1016/S1473-3099(23)00352-3. Epub 2023 Jul 17.PMID: 37475115 Free PMC article.

Genomic and ultrastructural analysis of monkeypox virus in skin lesions and in human/animal infected cells reveals further morphofunctional insights into viral pathogenicity.
Paniz-Mondolfi A, Reidy J, Pagani N, Lednicky JA, McGrail JP, Kasminskaya Y, Patino LH, Garcia-Sastre A, Palacios G, Gonzalez-Reiche AS, van Bakel H, Firpo Betancourt A, Hernandez MM, Cordon-Cardo C, Simon V, Sordillo EM, Ramírez JD, Guerra S.J Med Virol. 2023 Jun;95(6):e28878. doi: 10.1002/jmv.28878.PMID: 37322614

 

HIV

Development of an HIV reporter virus that identifies latently infected CD4+ T cells.
Kim EH, Manganaro L, Schotsaert M, Brown BD, Mulder LCF, Simon V.Cell Rep Methods. 2022 Jun 13;2(6):100238. doi: 10.1016/j.crmeth.2022.100238. eCollection 2022 Jun 20.PMID: 35784650 Free PMC article.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling.
Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ.Cell Rep. 2022 Apr 12;39(2):110690. doi: 10.1016/j.celrep.2022.110690.PMID: 35417684 Free PMC article.

 

HERVs

An integrated approach for the accurate detection of HERV-K HML-2 transcription and protein synthesis.
Gleason C, Terry SN, Hernandez MM, Jacob S, Fenyo D, Johnson JR, Deikus G, Francoeur N, Hahn A, Sebra R, Zamarin D, Molina H, Simon V, Mulder LCF.Nucleic Acids Res. 2025 Jan 11;53(2):gkaf011. doi: 10.1093/nar/gkaf011.PMID: 39831303 Free PMC article.