Samuel Sidi, PhD 
PROFESSOR
Developmental & Regenerative Biology
Medicine (Division of Hematology and Medical Oncology)
Oncological Sciences 

Ando, William Kiyohiro
POSTDOCTORAL FELLOW
william.ando@mssm.edu

I am focusing on the mechanism of caspase-2 activation in the Chk1-suppressed apoptotic pathway. I am also working on a genome-wide siena screen for new pathway components.

Closser, Evan
RESEARCH ASSOCIATE
evan.closser@mssm.edu

Zebrafish Facility Manager

Di Giandomenico, Silvana
POSTDOCTORAL FELLOW
silvana.digiandomenico@mssm.edu

My research seeks to define the genetic determinants of tumor cell response to radiation plus Chk1 inhibition. I am screening large panels of genotypical annotated cancer cell lines for their ability to activate caspase-2 after treatment. Candidate predictive genotypes are then validated in zebrafish, ex vivo patient cultures, xenograft models.

Kernan, Jennifer
RESEARCH COORDINATOR
jennifer.kernan@mssm.edu

I am interested in the molecular events that lead to the execution of the Chk1-suppressed apoptotic program downstream of caspase-2 activation. Specifically, I am searching for regulators and substrates of this caspase using genetic and proteomic approaches.

Liu, Peter
STUDENT
peter.hongdau@gmail.com

I seek to find novel compounds that are synthetically lethal to p53 deficiency using zebrafish as a high-throughput screening system for small-molecule inhibitors.

Thompson, Ruth
POSTDOCTORAL FELLOW
ruth.thompson@mssm.edu

My work focuses on the mechanism by which Chk1 negatively regulates PIDDosome assembly and activation in the Chk1-suppressed apoptotic pathway. I am also using a genome-wide siRNA screen to identify new pathway components.

Mernacej, Jolanda
ADMINISTRATIVE ASSISTANT
jolanda.mernacej@mssm.edu