TRIPARNA SEN, PhD

Associate Professor
Department of Oncological Sciences
The Tisch Cancer Institute
Co-Director, Lung Cancer PDX Program

Dr. Triparna Sen is an Associate Professor in the Department of Oncological Sciences, and the Director of the Lung Cancer PDX Platform at the Icahn School of Medicine at Mount Sinai, New York. Dr. Sen is a cell and molecular biologist with a Ph.D. in cancer biology. She leads a multi-disciplinary team of investigators in laboratory-based, patient-focused investigations focused on cancer biology and precision medicine. Her final goal is to develop treatments that will lengthen and improve the quality of the lives of cancer patients.

Dr. Sen is focused on understanding the biology and development of new treatment paradigms for clinically relevant molecular subsets of lung cancer, like non-small cell lung cancer (NSCLC), and small cell lung cancer (SCLC). Sr. Sen is a pioneer in the field of lung cancer research and has driven fundamental advances in the understanding and characterization of SCLC, the most aggressive form of lung cancer. Previously, Dr. Sen identified that DNA damage response (DDR) proteins are effective therapeutic targets for small-cell lung cancer treatment and that targeting DDR promotes antitumor immunity through the activation of innate immune signaling. In her recent work, Dr. Sen identified molecular determinants and novel therapeutic targets for lineage plasticity in lung cancer.