Samstein RM*, Krishna C*, Ma X* et al. Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy. Nature Cancer 2020 Nov 16. https://doi.org/10.1038/s43018-020-00139-8.
Mandal R*, Samstein RM*, Lee KW*, …, Chan TA. Genetic Diversity of Tumors with Mismatch Repair Deficiency Influences Tumor Evolution and Response to PD-1 Blockade. Science. 2019 May 3;364(6439):485-491.
Chowell D, Morris LGT, Grigg CM, Weber JK, Samstein RM, Makarov V, Kuo F, Kendall SM, Requena D, Riaz N, Greenbaum B, Carroll J, Garon E, Hyman DM, Zehir A, Solit D, Berger M, Zhou R, Rizvi NA, Chan TA. Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science. 2018 Feb 2;359(6375):582-587.
Samstein RM*, Lee CH*, Shoushtari AN*, Hellman MD*, …, Riaz N, Morris LGT, Solit DB, Chan TA. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nature Genetics, 2019 Feb;51(2):202-206.
Lee M*, Samstein RM*, Valero C, Chan TA, Morris LGT. Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy. Hum Vaccin Immunother. 2019 Jul 30:1-4.
Khalil DN, Suek N, Campesato LF, Budhu S, Redmond D, Samstein RM, Krishna C, …, Wolchok JD, Merghoub T. In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors. J Clin Invest. 2019 Jul 22;129(8):3435-3447.
Mandal R*, Samstein RM*, Lee KW*, …, Chan TA. Genetic Diversity of Tumors with Mismatch Repair Deficiency Influences Tumor Evolution and Response to PD-1 Blockade. Science. 2019 May 3;364(6439):485-491.
Featured in New England Journal of Medicine’s Clinical Implication of Basic Research
Yang W, Lee KW, Srivastava RM, Kuo F, Krishna C, …, Samstein RM, …,Chan TA, Morris LGT. Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat Med. 2019 May;25(5):767-775.s
Samstein RM*, Lee CH*, Shoushtari AN*, Hellman MD*, …, Riaz N, Morris LGT, Solit DB, Chan TA. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nature Genetics, 2019 Feb;51(2):202-206.
#1 trending paper on Pubmed for several weeks
Markovsky E, Budhu S, Samstein RM, Li H, Russell J, …, Haimovitz-Friedman A. An anti-tumor immune response is evoked by partial-volume single dose radiation in two murine models. Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):697-708.
Chowell D, Morris LGT, Grigg CM, Weber JK, Samstein RM, Makarov V, Kuo F, Kendall SM, Requena D, Riaz N, Greenbaum B, Carroll J, Garon E, Hyman DM, Zehir A, Solit D, Berger M, Zhou R, Rizvi NA, Chan TA. Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science. 2018 Feb 2;359(6375):582-587.
Ulaner GA, Samstein R, Cahlon O, Weber WA, Rimner A. Unilateral Suppression of Brown Fat on FDG PET/CT in Horner Syndrome. Clin Nucl Med. 2016 Oct;41(10):797-8.
Samstein RM, Carvajal RD, Postow MA, Callahan MK, Shoushtari AN, Patel SG, Lee NY, Barker CA. Localized sinonasal mucosal melanoma: Outcomes and associations with stage, radiotherapy, and positron emission tomography response. Head Neck. 2016 Sep;38(9):1310-7.
Vierstra J, Rynes E, … Samstein R, et. al. Mouse ENCODE Consortium. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science. 2014 Nov 21;346(6212):1007-12.
Yue F, Cheng Y, … Samstein R, et. al. Mouse ENCODE Consortium. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20;515(7527):355-64.
Samstein RM, Ho AL, Lee NY, Barker CA. Locally advanced and unresectable cutaneous squamous cell carcinoma: outcomes of concurrent cetuximab and radiotherapy. J Skin Cancer. 2014;2014:284582.
Arvey A*, van der Veeken J*, Samstein RM*, Feng Y, Stamatoyannopoulos JA, Rudensky AY. Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nat Immunol. 2014 Jun;15(6):580-7.
Samstein RM*, Arvey A,* Josefowicz S*, Peng Z, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY. Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification. Cell. 2012 Sep 28;151(1):153-66.
Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol. 2012 Oct;13(10):1010-9.
Samstein RM, Josefowicz S, Arvey A, Treuting P, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012 Jul 6;150(1):29-38.
Featured in New England Journal of Medicine’s Clinical Implication of Basic Research
Chosen as sCell Best Papers of 2012
Chaudhry A*, Samstein RM,* Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, Rudensky AY. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011 Apr 22;34(4):566-78.
Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 2009 Nov 13;326(5955):986-91.
Samstein RM*, Perica K*, Balderrama F, Look M, Fahmy TM. The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles. Biomaterials. 2008 Feb;29(6):703-8.
Goldberg, G.L., King, C.G., Nejat, R.A., Suh, D.Y., Smith, O.M., Bretz, J.C., Samstein, R.M., Dudakov, J.A., Chidgey, A.P., Chen-Kiang, S., Boyd, R.L., van den Brink, M.R.. 2009. Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation. J Immunol. 182(9):5846-54. PMC2760441
Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y, Tesio M, Samstein RM, Goichberg P, Spiegel A, Elson A, Lapidot T. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med. 2006 Jun;12(6):657-64.
Fahmy TM, Samstein RM, Harness CC, Mark Saltzman W. Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomaterials. 2005 Oct;26(28):5727-36.
Complete List of Published Work in My Bibliography:
https://www.ncbi.nlm.nih.gov/sites/myncbi/robert.samstein.1/bibliography/43676298/public/