Dr. Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumor, elucidating the role of the DNA damage repair and response pathways in altering the tumor’s ability to be recognized and attacked by the immune system. His laboratory will work to identify new strategies to harness the immune anti-tumor response and expand the therapeutic window of traditional immunotherapies.
Robert Samstein, MD PhD is a radiation oncologist in the Department of Radiation Oncology at Mount Sinai and a physician scientist with a laboratory in the Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai. He completed his graduate work with Alexander Rudensky studying the development and function of regulatory T cells. He completed his transitional year internship and residency in radiation oncology at Memorial Sloan Kettering Cancer Center in New York, NY. During residency, he conducted laboratory research with Dr. Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.