2019

CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder.
Hoffman GE, Bendl J, Voloudakis G, Montgomery KS, Sloofman L, Wang YC, Shah HR, Hauberg ME, Johnson JS, Girdhar K, Song L, Fullard JF, Kramer R, Hahn CG, Gur R, Marenco S, Lipska BK, Lewis DA, Haroutunian V, Hemby S, Sullivan P, Akbarian S, Chess A, Buxbaum JD, Crawford GE, Domenici E, Devlin B, Sieberts SK, Peters MA, Roussos P.
Sci Data. 2019 Sep 24;6(1):180. doi: 10.1038/s41597-019-0183-6. PMID: 31551426

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification.
Hoffman GE, Bendl J, Girdhar K, Schadt EE, Roussos P.
Nucleic Acids Res. 2019 Sep 23. pii: gkz808. doi: 10.1093/nar/gkz808. [Epub ahead of print] PMID: 31544924

A polygenic resilience score moderates the genetic risk for schizophrenia.
Hess JL, Tylee DS, Mattheisen M; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum AD, Als TD, Grove J, Werge T, Mortensen PB, Mors O, Nordentoft M, Hougaard DM, Byberg-Grauholm J, Bækvad-Hansen M, Greenwood TA, Tsuang MT, Curtis D, Steinberg S, Sigurdsson E, Stefánsson H, Stefánsson K, Edenberg HJ, Holmans P, Faraone SV, Glatt SJ.
Mol Psychiatry. 2019 Sep 6. doi: 10.1038/s41380-019-0463-8. [Epub ahead of print] PMID: 31492941

Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia.
Breen MS, Dobbyn A, Li Q, Roussos P, Hoffman GE, Stahl E, Chess A, Sklar P, Li JB, Devlin B, Buxbaum JD; CommonMind Consortium.
Nat Neurosci. 2019 Sep;22(9):1402-1412. doi: 10.1038/s41593-019-0463-7. Epub 2019 Aug 27. PMID:31455887

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.
Zhang W, Voloudakis G, Rajagopal VM, Readhead B, Dudley JT, Schadt EE, Björkegren JLM, Kim Y, Fullard JF, Hoffman GE, Roussos P.
Nat Commun. 2019 Aug 23;10(1):3834. doi: 10.1038/s41467-019-11874-7. PMID:31444360  

Genetic Variation in Long-Range Enhancers.
Fullard JF, Rahman S, Roussos P.
Curr Top Behav Neurosci. 2019 Aug 9. doi: 10.1007/7854_2019_110. [Epub ahead of print] PMID:31396896

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
Lam M, Hill WD, Trampush JW, Yu J, Knowles E, Davies G, Stahl E, Huckins L, Liewald DC, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Hartmann AM, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T.
Am J Hum Genet. 2019 Aug 1;105(2):334-350. doi: 10.1016/j.ajhg.2019.06.012.PMID:31374203

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S; CommonMind Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O’Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA.
Nat Genet. 2019 Jun;51(6):1068. doi: 10.1038/s41588-019-0435-6. PMID:31086353

Genome-wide association study identifies 30 loci associated with bipolar disorder.
Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A, Antilla V, Awasthi S, Badner JA, Bækvad-Hansen M, Barchas JD, Bass N, Bauer M, Belliveau R, Bergen SE, Pedersen CB, Bøen E, Boks MP, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Casas M, Cerrato F, Cervantes P, Chambert K, Charney AW, Chen D, Churchhouse C, Clarke TK, Coryell W, Craig DW, Cruceanu C, Curtis D, Czerski PM, Dale AM, de Jong S, Degenhardt F, Del-Favero J, DePaulo JR, Djurovic S, Dobbyn AL, Dumont A, Elvsåshagen T, Escott-Price V, Fan CC, Fischer SB, Flickinger M, Foroud TM, Forty L, Frank J, Fraser C, Freimer NB, Frisén L, Gade K, Gage D, Garnham J, Giambartolomei C, Pedersen MG, Goldstein J, Gordon SD, Gordon-Smith K, Green EK, Green MJ, Greenwood TA, Grove J, Guan W, Guzman-Parra J, Hamshere ML, Hautzinger M, Heilbronner U, Herms S, Hipolito M, Hoffmann P, Holland D, Huckins L, Jamain S, Johnson JS, Juréus A, Kandaswamy R, Karlsson R, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koller AC, Kupka R, Lavebratt C, Lawrence J, Lawson WB, Leber M, Lee PH, Levy SE, Li JZ, Liu C, Lucae S, Maaser A, MacIntyre DJ, Mahon PB, Maier W, Martinsson L, McCarroll S, McGuffin P, McInnis MG, McKay JD, Medeiros H, Medland SE, Meng F, Milani L, Montgomery GW, Morris DW, Mühleisen TW, Mullins N, Nguyen H, Nievergelt CM, Adolfsson AN, Nwulia EA, O’Donovan C, Loohuis LMO, Ori APS, Oruc L, Ösby U, Perlis RH, Perry A, Pfennig A, Potash JB, Purcell SM, Regeer EJ, Reif A, Reinbold CS, Rice JP, Rivas F, Rivera M, Roussos P, Ruderfer DM, Ryu E, Sánchez-Mora C, Schatzberg AF, Scheftner WA, Schork NJ, Shannon Weickert C, Shehktman T, Shilling PD, Sigurdsson E, Slaney C, Smeland OB, Sobell JL, Søholm Hansen C, Spijker AT, St Clair D, Steffens M, Strauss JS, Streit F, Strohmaier J, Szelinger S, Thompson RC, Thorgeirsson TE, Treutlein J, Vedder H, Wang W, Watson SJ, Weickert TW, Witt SH, Xi S, Xu W, Young AH, Zandi P, Zhang P, Zöllner S; eQTLGen Consortium; BIOS Consortium, Adolfsson R, Agartz I, Alda M, Backlund L, Baune BT, Bellivier F, Berrettini WH, Biernacka JM, Blackwood DHR, Boehnke M, Børglum AD, Corvin A, Craddock N, Daly MJ, Dannlowski U, Esko T, Etain B, Frye M, Fullerton JM, Gershon ES, Gill M, Goes F, Grigoroiu-Serbanescu M, Hauser J, Hougaard DM, Hultman CM, Jones I, Jones LA, Kahn RS, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Martin NG, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Metspalu A, Mitchell PB, Morken G, Mors O, Mortensen PB, Müller-Myhsok B, Myers RM, Neale BM, Nimgaonkar V, Nordentoft M, Nöthen MM, O’Donovan MC, Oedegaard KJ, Owen MJ, Paciga SA, Pato C, Pato MT, Posthuma D, Ramos-Quiroga JA, Ribasés M, Rietschel M, Rouleau GA, Schalling M, Schofield PR, Schulze TG, Serretti A, Smoller JW, Stefansson H, Stefansson K, Stordal E, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Werge T, Nurnberger JI, Wray NR, Di Florio A, Edenberg HJ, Cichon S, Ophoff RA, Scott LJ, Andreassen OA, Kelsoe J, Sklar P; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium.
Nat Genet. 2019 May;51(5):793-803. doi: 10.1038/s41588-019-0397-8. Epub 2019 May 1. PMID:31043756  

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Lill CM, Liu T, Koini M, London E, Longstreth WT Jr, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Dan Rujescu, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH Jr, Bressler J, Lencz T, Deary IJ.
Nat Commun. 2019 May 1;10(1):2068. doi: 10.1038/s41467-019-10160-w. PMID:31043617  

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes.
Drange OK, Smeland OB, Shadrin AA, Finseth PI, Witoelar A, Frei O; Psychiatric Genomics Consortium Bipolar Disorder Working Group, Wang Y, Hassani S, Djurovic S, Dale AM, Andreassen OA.
Front Neurosci. 2019 Mar 13;13:220. doi: 10.3389/fnins.2019.00220. eCollection 2019. PMID:30930738  

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S; CommonMind Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O’Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA.
Nat Genet. 2019 Apr;51(4):659-674. doi: 10.1038/s41588-019-0364-4. Epub 2019 Mar 25. Erratum in: Nat Genet. 2019 Jun;51(6):1068.  PMID:30911161  

Identification of common genetic risk variants for autism spectrum disorder.
Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD.
Nat Genet. 2019 Mar;51(3):431-444. doi: 10.1038/s41588-019-0344-8. Epub 2019 Feb 25. PMID:30804558

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.
Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ, O’Donovan MC, Walters J; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Donohoe G, Gill M, Corvin A, Morris DW.
Am J Med Genet B Neuropsychiatr Genet. 2019 Apr;180(3):223-231. doi: 10.1002/ajmg.b.32716. Epub 2019 Feb 23. PMID:30801977

The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription.
Katsel P, Roussos P, Fam P, Khan S, Tan W, Hirose T, Nakagawa S, Pletnikov MV, Haroutunian V.
NPJ Schizophr. 2019 Jan 29;5(1):3. doi: 10.1038/s41537-019-0071-2. PMID:30696826  

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S; CommonMind Consortium; Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium; iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O’Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA.
Nat Genet. 2019 Mar 25. doi: 10.1038/s41588-019-0364-4. [Epub ahead of print] PMID:30911161

Cell- and layer-specific transcriptomic strategy for characterizing the molecular phenotype of rat cortical neurons using laser capture microdissection and massively parallel RNA sequencing.
Miller ML, Chadwick B, Dickstein DL, Purushothaman I, Egervari G, Rahman T, Tessereau C, Hof PR, Roussos P, Shen L, Baxter MG, Hurd YL.
Mol Psychiatry. 2019 Apr;24(4):473. doi: 10.1038/s41380-019-0390-8. No abstract available.PMID:30899095

Identification of common genetic risk variants for autism spectrum disorder.
Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD.
Nat Genet. 2019 Mar;51(3):431-444. doi: 10.1038/s41588-019-0344-8. Epub 2019 Feb 25. PMID:30804558

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.
Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ, O’Donovan MC, Walters J; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Donohoe G, Gill M, Corvin A, Morris DW.
Am J Med Genet B Neuropsychiatr Genet. 2019 Apr;180(3):223-231. doi: 10.1002/ajmg.b.32716. Epub 2019 Feb 23. PMID:30801977

The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription.
Katsel P, Roussos P, Fam P, Khan S, Tan W, Hirose T, Nakagawa S, Pletnikov MV, Haroutunian V.
NPJ Schizophr. 2019 Jan 29;5(1):3. doi: 10.1038/s41537-019-0071-2. PMID: 30696826

Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia.
Fullard JF, Charney AW, Voloudakis G, Uzilov AV, Haroutunian V, Roussos P.
Transl Psychiatry. 2019 Jan 17;9(1):21. doi: 10.1038/s41398-018-0342-0. PMID: 30655504

2018

Biopsy During Minimally Invasive Intracerebral Hemorrhage Clot Evacuation.
Lieber AC, McNeill IT, Scaggiante J, Nistal DA, Fowkes M, Umphlett M, Pan J, Roussos P, Mobbs CV, Mocco J, Kellner CP.
World Neurosurg. 2018 Dec 24. pii: S1878-8750(18)32881-X. doi: 10.1016/j.wneu.2018.12.058. [Epub ahead of print] PMID: 30590212

Comprehensive functional genomic resource and integrative model for the human brain.
Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüş ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.
Science. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126/science.aat8464. PMID: 30545857

Integrative functional genomic analysis of human brain development and neuropsychiatric risks.
Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup, Hu M, Jin F, Li Y, Owen MJ, O’Donovan MC, Walters JTR, Posthuma D, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N.
Science. 2018 Dec 14;362(6420). pii: eaat7615. doi: 10.1126/science.aat7615. PMID: 30545854

Transcriptome and epigenome landscape of human cortical development modeled in organoids.
Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM; PsychENCODE Consortium, Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM.
Science. 2018 Dec 14;362(6420). pii: eaat6720. doi: 10.1126/science.aat6720. PMID: 30545853

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.
Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S.
Science. 2018 Dec 14;362(6420). pii: eaat4311. doi: 10.1126/science.aat4311. PMID: 30545851

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O’Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O’Donnell CJ.
Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PMID: 30510157

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.
Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team, Andreassen OA, Asherson P, Burton CL, Boomsma DI, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler HR, Kuntsi J, Langley K, Lesch KP, Middeldorp C, Reif A, Rohde LA, Roussos P, Schachar R, Sklar P, Sonuga-Barke EJS, Sullivan PF, Thapar A, Tung JY, Waldman ID, Medland SE, Stefansson K, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Daly MJ, Faraone SV, Børglum AD, Neale BM.
Nat Genet. 2019 Jan;51(1):63-75. doi: 10.1038/s41588-018-0269-7. Epub 2018 Nov 26. PMID: 30478444

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer’s disease and normalized by treatment with anti-diabetic agents.
Katsel P, Roussos P, Beeri MS, Gama-Sosa MA, Gandy S, Khan S, Haroutunian V.
PLoS One. 2018 Nov 1;13(11):e0206547. doi: 10.1371/journal.pone.0206547. eCollection 2018. PMID:30383799

Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons.
Miller ML, Chadwick B, Dickstein DL, Purushothaman I, Egervari G, Rahman T, Tessereau C, Hof PR, Roussos P, Shen L, Baxter MG, Hurd YL.
Mol Psychiatry. 2018 Oct 3. doi: 10.1038/s41380-018-0243-x. [Epub ahead of print] PMID:30283037

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
Wang HY, MacDonald ML, Borgmann-Winter KE, Banerjee A, Sleiman P, Tom A, Khan A, Lee KC, Roussos P, Siegel SJ, Hemby SE, Bilker WB, Gur RE, Hahn CG.
Mol Psychiatry. 2018 Sep 13. doi: 10.1038/s41380-018-0234-y. [Epub ahead of print] PMID: 30214040

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer’s disease
Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, Mahajan M, Mangravite LM, Dammer EB, Duong DM, Lah JJ, Seyfried NT, Levey AI, Buxbaum JD, Ehrlich M, Gandy S, Katsel P, Haroutunian V, Schadt E, Zhang B.
Sci Data. 2018 Sep 11;5:180185. doi: 10.1038/sdata.2018.185. PMID: 30204156

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia
Bryois J, Garrett ME, Song L, Safi A, Giusti-Rodriguez P, Johnson GD, Shieh AW, Buil A, Fullard JFRoussos P, Sklar P, Akbarian S, Haroutunian V, Stockmeier CA, Wray GA, White KP, Liu C, Reddy TE, Ashley-Koch A, Sullivan PF, Crawford GE.
Nat Commun. 2018 Aug 7;9(1):3121. doi: 10.1038/s41467-018-05379-y. PMID: 30087329

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome

Volume 21 Issue 8

Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, Francoeur NJ, Wang YC, Shah H, Kavanagh DH, Zharovsky E, Jacobov R, Wiseman JR, Park R, Johnson JS, Kassim BS, Sloofman L, Mattei E, Weng Z, Sieberts SK, Peters MA, Harris BT, Lipska BK, Sklar P, Roussos P, Akbarian S.
Nat Neurosci. 2018 Jul 23. doi: 10.1038/s41593-018-0187-0. [Epub ahead of print] PMID:30038276
← Featured at journal cover (art created by Jessica Johnson)

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)
Lam M, Trampush JW, Yu J, Knowles E, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Glahn DC, Malhotra AK, Lencz T.
Twin Res Hum Genet. 2018 Jul 13:1-4. doi: 10.1017/thg.2018.46. [Epub ahead of print] PMID:30001766

Age at first birth in women is genetically associated with increased risk of schizophrenia
Ni G, Gratten J, Wray NR, Lee SH; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Sci Rep. 2018 Jul 5;8(1):10168. doi: 10.1038/s41598-018-28160-z. PMID: 29977057

An atlas of chromatin accessibility in the adult human brain
Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P.
Genome Res. 2018 Jun 26. pii: gr.232488.117. doi: 10.1101/gr.232488.117. [Epub ahead of print] PMID: 29945882

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Savage JE, Jansen PR, Stringer S, Watanabe K, …, Roussos P, …, Sullivan PF, Vrieze SI, Wright MJ, Posthuma D.
Nat Genet. 2018 Jun 25. doi: 10.1038/s41588-018-0152-6. [Epub ahead of print] PMID:29942086

Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, …, Roussos P, …,Sullivan P, Rosand J, Corvin A, Neale BM.
Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757. PMID: 29930110

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: douglas.ruderfer@vanderbilt.edu; Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Cell. 2018 Jun 14;173(7):1705-1715.e16. doi: 10.1016/j.cell.2018.05.046. PMID: 29906448

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, Hurd YL, Dracheva S, Casaccia P, Roussos P, Zhang B.
Sci Rep. 2018 Jun 11;8(1):8868. doi: 10.1038/s41598-018-27293-5. PMID: 29892006

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Davies G, Lam M, Harris SE, Trampush JW,…, Roussos P,…, Mosley TH Jr, Bressler J, Lencz T, Deary IJ.
Nat Commun. 2018 May 29;9(1):2098. doi: 10.1038/s41467-018-04362-x. PMID: 29844566

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS
Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei CHoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D; CommonMind Consortium, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl EA, Sieberts SK.
Am J Hum Genet. 2018 Jun 7;102(6):1169-1184. doi: 10.1016/j.ajhg.2018.04.011. Epub 2018 May 24. PMID: 29805045

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
Ni G, Moser G; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Wray NR, Lee SH.
Am J Hum Genet. 2018 Apr 26. pii: S0002-9297(18)30110-1. doi: 10.1016/j.ajhg.2018.03.021. [Epub ahead of print] PMID: 29754766

Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls
Hauberg ME, Fullard JF, Zhu L, Cohain AT, Giambartolomei C, Misir R, Reach S, Johnson JS, Wang M, Mattheisen M, Børglum AD, Zhang B, Sieberts SK, Peters MA, Domenici E, Schadt EE, Devlin B, Sklar P, Roeder K, Roussos P; CommonMind Consortium.
Mol Psychiatry. 2018 May 8. doi: 10.1038/s41380-018-0059-8. [Epub ahead of print] PMID: 2974012

THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders
Guennewig B, Bitar M, Obiorah I, Hanks J, O’Brien EA, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G.
Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3. PMID:2969137

A Bayesian Framework for Multiple Trait Colo-calization from Summary Association Statistics
Giambartolomei C, Zhenli Liu J, Zhang W, Hauberg M, Shi H, Boocock J, Pickrell J, Jaffe AE; CommonMind Consortium, Pasaniuc B, Roussos P.
Bioinformatics. 2018 Mar 19. doi: 10.1093/bioinformatics/bty147. [Epub ahead of print] PMID:29579179

Frontal and temporal cortical volume, white matter tract integrity, and hemispheric asymmetry in schizotypal personality disorder
Chan CC, Szeszko PR, Wong E, Tang CY, Kelliher C, Penner JD, Perez-Rodriguez MM, Rosell DR, McClure M, Roussos P, New AS, Siever LJ, Hazlett EA.
Schizophr Res. 2018 Feb 14. pii: S0920-9964(18)30047-1. doi: 10.1016/j.schres.2018.01.025. [Epub ahead of print] PMID:29454512

2017

Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response
Quednow BB, Ejebe K, Wagner M, Giakoumaki SG, Bitsios P, Kumari V, Roussos P.
Schizophr Res. 2017 Dec 26. pii: S0920-9964(17)30763-6. doi: 10.1016/j.schres.2017.12.011. [Epub ahead of print] PMID: 29287625

Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets
Lam M, Trampush JW, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T.
Cell Rep. 2017 Nov 28;21(9):2597-2613. doi: 10.1016/j.celrep.2017.11.028. PMID: 29186694

Winter birth, urbanicity and immigrant status predict psychometric schizotypy dimensions in adolescents
Mimarakis D, Roumeliotaki T, Roussos P, Giakoumaki SG, Bitsios P.
Eur Psychiatry. 2017 Sep 18;47:9-18. doi: 10.1016/j.eurpsy.2017.07.014. [Epub ahead of print] PMID: 29096131

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Trampush JW, Yang MLZ, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T.
Mol Psychiatry. 2017 Nov;22(11):1651-1652. doi: 10.1038/mp.2017. 197.  Epub 2017 Sep 12. PMID: 29068436

Stress-Dependent Association Between Polygenic Risk for Schizophrenia and Schizotypal Traits in Young Army Recruits
Hatzimanolis A, Avramopoulos D, Arking DE, Moes A, Bhatnagar P, Lencz T, Malhotra AK, Giakoumaki SG, Roussos P, Smyrnis N, Bitsios P, Stefanis NC.
Schizophr Bull. 2017 Jun 13. doi: 10.1093/schbul/sbx074. [Epub ahead of print] PMID: 29036523

A functional genomics predictive network model identifies regulators of inflammatory bowel disease
Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE.
Nat Genet. 2017 Oct;49(10):1437-1449. doi: 10.1038/ng.3947. Epub 2017 Sep 11. PMID: 28892060

Dimensional Traits of Schizotypy Associated With Glycine Receptor GLRA1 Polymorphism: An Exploratory Candidate-Gene Association Study
Vora AK, Fisher AM, New AS, Hazlett EA, McNamara M, Yuan Q, Zhou Z, Hodgkinson C, Goldman D, Siever LJ, Roussos P, Perez-Rodriguez MM.
J Pers Disord. 2017 Jul 31:1-12. doi: 10.1521/pedi_2017_31_303. [Epub ahead of print] PMID: 28758885

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.
Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3. PMID: 28671686

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression
Hauberg MEZhang WGiambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A; CommonMind Consortium, Sklar P, Schadt EE, Björkegren JLM, Roussos P.
Am J Hum Genet. 2017 Jun 1;100(6):885-894. doi: 10.1016/j.ajhg. 2017.04.016. Epub 2017 May 25. PMID:28552197

minepath.org: a free interactive pathway analysis web server
Koumakis L, Roussos P, Potamias G.
Nucleic Acids Res. 2017 Apr 20. doi: 10.1093/nar/gkx278. [Epub ahead of print] PMID: 28431175

Microvascular anomaly conditions in psychiatric disease. Schizophrenia – angiogenesis connection
Katsel P, Roussos P, Pletnikov M, Haroutunian V.
Neurosci Biobehav Rev. 2017 Jun;77:327-339. doi: 10.1016/j.neubiorev.2017.04.003. Epub 2017 Apr 8. Review. PMID: 28396239

Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci
Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P.
Hum Mol Genet. 2018 Jun 29. doi: 10.1093/hmg/ddy229. [Epub ahead of print] No abstract available. PMID: 29982455

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O’Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Nat Commun. 2017 Mar 21;8:14774. doi: 10.1038/ncomms14774. PMID: 28322246

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Trampush JW, Yang ML, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T.
Mol Psychiatry. 2017 Mar;22(3):336-345. doi: 10.1038/mp. 2016.244. Epub 2017 Jan 17. PMID: 28093568

Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P.
Transl Psychiatry. 2017 Jan 10;7(1):e993. doi: 10.1038/tp.2016.242. PMID: 28072414

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D’Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MY, Zhu K, Wang S, Roussos P, Schadt EE, Pandey G, Chang R, Quertermous T, Lemischka I.
Cell Stem Cell. 2017 Apr 6;20(4):518-532.e9. doi: 10.1016/j.stem. 2016.11.005. Epub 2016 Dec 22. PMID: 2801779

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, …, Roussos P, …, Scherer SW, Neale BM, Sebat J; CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium.
Nat Genet. 2017 Jan;49(1):27-35. doi: 10.1038/ng.3725. Epub 2016 Nov 21. PMID: 27869829

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target
Egervari G, Landry J, Callens J, Fullard JFRoussos P, Keller E, Hurd YL.
Biol Psychiatry. 2017 Apr 1;81(7):585-594. doi: 10.1016/j.biopsych. 2016.09.015. Epub 2016 Sep 28. PMID:27863698

 

2016

Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons
Roussos P, Guennewig B, Kaczorowski DC, Barry G, Brennand KJ.
JAMA Psychiatry. 2016 Nov 1;73(11):1180-1188. doi: 10.1001/jamapsychiatry.2016.2575. PMID: 27732689

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, Haroutunian V, Zhang B.
Genome Med. 2016 Nov 1;8(1):104. PMID: 27799057

Gene expression elucidates functional impact of polygenic risk for schizophrenia
Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P.
Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26. PMID: 27668389

Associations of differential schizotypal dimensions with executive working memory: A moderated-mediation analysis
Zouraraki C, Tsaousis I, Karamaouna P, Karagiannopoulou L, Roussos P, Bitsios P, Giakoumaki SG.
Compr Psychiatry. 2016 Nov;71:39-48. doi: 10.1016/j.comppsych. 2016.08.010. Epub 2016 Aug 21. PMID: 27621208

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei CFullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JL.
Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126/science.aad 6970. PMID: 27540175

Cognitive profiles of schizotypal dimensions in a community cohort: Common properties of differential manifestations
Karagiannopoulou L, Karamaouna P, Zouraraki C, Roussos P, Bitsios P, Giakoumaki SG.
J Clin Exp Neuropsychol. 2016 Nov;38(9):1050-63. doi: 10.1080/13803395.2016.1188890. Epub 2016 Jun 13. PMID: 27295077

Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue
Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, Fromer M, Harris B, Lipska BK, Peters MA, Sklar P, Akbarian S.
Biol Psychiatry. 2017 Jan 15;81(2):162-170. doi: 10.1016/j.biopsych. 2016.03.1048. Epub 2016 Mar 9. PMID: 27113501

Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants
Hauberg MERoussos P, Grove J, Børglum AD, Mattheisen M; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
JAMA Psychiatry. 2016 Apr;73(4):369-77. doi: 10.1001/jamapsychiatry.2015.3018. PMID: 26963595

Understanding the genetic liability to schizophrenia through the neuroepigenome
Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P.Schizophr Res. 2016 Nov;177(1-3):115-124. doi: 10.1016/j.schres.2016.01.039. Epub 2016 Jan 27. Review. PMID: 26827128

Schizophrenia risk from complex variation of complement component 4
Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA.
Nature. 2016 Feb 11;530(7589):177-83. doi: 10.1038/nature16549. Epub 2016 Jan 27. PMID: 26814963

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease
Watson CT, Roussos P, Garg P, Ho DJ, Azam N, Katsel PL, Haroutunian V, Sharp AJ.
Genome Med. 2016 Jan 19;8(1):5. doi: 10.1186/s13073-015-0258-8. PMID: 26803900

NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure
Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S.
Schizophr Res. 2016 Feb;170(2-3):235-44. doi: 10.1016/j.schres. 2015.12.016. Epub 2016 Jan 6. PMID: 26776227

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
Bigdeli TB, Ripke S, Bacanu SA, Lee SH, Wray NR, Gejman PV, Rietschel M, Cichon S, St Clair D, Corvin A, Kirov G, McQuillin A, Gurling H, Rujescu D, Andreassen OA, Werge T, Blackwood DH, Pato CN, Pato MT, Malhotra AK, O’Donovan MC, Kendler KS, Fanous AH; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Am J Med Genet B Neuropsychiatr Genet. 2016 Mar;171B(2):276-89. doi: 10.1002/ajmg.b.32402. Epub 2015 Dec 11. PMID: 26663532

Substantial DNA methylation differences between two major neuronal subtypes in human brain
Kozlenkov A, Wang M, Roussos P, Rudchenko S, Barbu M, Bibikova M, Klotzle B, Dwork AJ, Zhang B, Hurd YL, Koonin EV, Wegner M, Dracheva S.
Nucleic Acids Res. 2016 Apr 7;44(6):2593-612. doi: 10.1093/nar/gkv1304. Epub 2015 Nov 26. PMID: 26612861

2015

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease
Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z.
PLoS One. 2015 Dec 4;10(12):e0144398. doi: 10.1371/journal.pone. 0144398. eCollection 2015. PMID: 26636336

The PsychENCODE project
PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N.
Nat Neurosci. 2015 Dec;18(12):1707-12. doi: 10.1038/nn.4156. Review. No abstract available. PMID: 26605881

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ; Schizophrenia Working Group of Psychiatric Genomics Consortium, de Candia TR, Lee SH, Wray NR, Kendler KS, O’Donovan MC, Neale BM, Patterson N, Price AL.
Nat Genet. 2015 Dec;47(12):1385-92. doi: 10.1038/ng.3431. Epub 2015 Nov 2. PMID: 26523775

Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease
Won HH, Natarajan P, Dobbyn A, Jordan DM, Roussos P, Lage K, Raychaudhuri S, Stahl E, Do R.
PLoS Genet. 2015 Oct 28;11(10):e1005622. doi: 10.1371/journal. pgen.1005622. eCollection 2015 Oct. PMID: 26509271

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA.
Mol Psychiatry. 2016 Sep;21(9):1290-7. doi: 10.1038/mp.2015.165. Epub 2015 Oct 27. Erratum in: Mol Psychiatry. 2017 Aug;22(8):1223PMID: 26503763

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL.
Am J Hum Genet. 2015 Oct 1;97(4):576-92. doi: 10.1016/j.ajhg. 2015.09.001. PMID: 26430803

Genome-wide autozygosity is associated with lower general cognitive ability
Howrigan DP, Simonson MA, Davies G, Harris SE, Tenesa A, Starr JM, Liewald DC, Deary IJ, McRae A, Wright MJ, Montgomery GW, Hansell N, Martin NG, Payton A, Horan M, Ollier WE, Abdellaoui A, Boomsma DI, DeRosse P, Knowles EE, Glahn DC, Djurovic S, Melle I, Andreassen OA, Christoforou A, Steen VM, Hellard SL, Sundet K, Reinvang I, Espeseth T, Lundervold AJ, Giegling I, Konte B, Hartmann AM, Rujescu D, Roussos P, Giakoumaki S, Burdick KE, Bitsios P, Donohoe G, Corley RP, Visscher PM, Pendleton N, Malhotra AK, Neale BM, Lencz T, Keller MC.
Mol Psychiatry. 2016 Jun;21(6):837-43. doi: 10.1038/mp.2015.120. Epub 2015 Sep 22. PMID: 26390830

The Relationship of Common Risk Variants and Polygenic Risk for Schizophrenia to Sensorimotor Gating
Roussos P, Giakoumaki SG, Zouraraki C, Fullard JFKaragiorga VE, Tsapakis EM, Petraki Z, Siever LJ, Lencz T, Malhotra A, Spanaki C, Bitsios P.
Biol Psychiatry. 2016 Jun 15;79(12):988-96. doi: 10.1016/j.biopsych. 2015.06.019. Epub 2015 Jun 27. PMID: 26212897

Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
Rees E, Kirov G, Walters JT, Richards AL, Howrigan D, Kavanagh DH, Pocklington AJ, Fromer M, Ruderfer DM, Georgieva L, Carrera N, Gormley P, Palta P, Williams H, Dwyer S, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Tsuang MT, Glatt SJ, Chen WJ, Hwu HG; Taiwanese Trios Exome Sequencing Consortium, Neale BM, Palotie A, Sklar P, Purcell SM, McCarroll SA, Holmans P, Owen MJ, O’Donovan MC.
Transl Psychiatry. 2015 Jul 21;5:e607. doi: 10.1038/tp.2015.99. PMID:26196440

Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia
O’Donovan SM, Hasselfeld K, Bauer D, Simmons M, Roussos P, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE.
Transl Psychiatry. 2015 Jun 9;5:e579. doi: 10.1038/tp.2015.74. PMID: 26057049

Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood
Hatzimanolis A, Bhatnagar P, Moes A, Wang R, Roussos P, Bitsios P, Stefanis CN, Pulver AE, Arking DE, Smyrnis N, Stefanis NC, Avramopoulos D.
Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):392-401. doi: 10.1002/ajmg.b.32323. Epub 2015 May 12. PMID: 25963331

Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
Trampush JW, Lencz T, Knowles E, Davies G, Guha S, Pe’er I, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Scult M, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri A, Weinberger DR, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK.
Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):363-73. doi: 10.1002/ajmg.b.32319. Epub 2015 May 7. PMID: 25951819

The effects of the CACNA1C rs1006737 A/G on affective startle modulation in healthy males
Pasparakis E, Koiliari E, Zouraraki C, Tsapakis EM, Roussos P, Giakoumaki SG, Bitsios P.
Eur Psychiatry. 2015 Jun;30(4):492-8. doi: 10.1016/j.eurpsy. 2015.03.004. Epub 2015 Apr 1. PMID: 25841664

Validation of electronic health record phenotyping of bipolar disorder cases and controls
Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW; International Cohort Collection for Bipolar Disorder Consortium.
Am J Psychiatry. 2015 Apr;172(4):363-72. doi: 10.1176/appi.ajp. 2014.14030423. Epub 2014 Dec 12. PMID: 25827034

Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia
Hertzberg L, Katsel P, Roussos P, Haroutunian V, Domany E.
Schizophr Res. 2015 May;164(1-3):92-9. doi: 10.1016/j.schres. 2015.02.001. Epub 2015 Feb 20. PMID: 25702973

Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions
Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT.
Mol Biol Evol. 2015 May;32(5):1148-60. doi: 10.1093/molbev/msv031. Epub 2015 Feb 12. PMID: 25681384

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM.Nat Genet. 2015 Mar;47(3):291-5. doi: 10.1038/ng.3211. Epub 2015 Feb 2. PMID: 25642630

The relationship between dopamine receptor D1 and cognitive performance
Tsang JFullard JF, Giakoumaki SG, Katsel P, Katsel P, Karagiorga VE, Greenwood TA, Braff DL, Siever LJ, Bitsios P, Haroutunian V, Roussos P.
NPJ Schizophr. 2015 Mar 4;1:14002. doi: 10.1038/npjschz.2014.2. eCollection 2015. Erratum in: NPJ Schizophr. 2015;1:15018PMID: 27336024

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer’s dementia
Roussos P, Katsel P, Fam P, Tan W, Purohit DP, Haroutunian V.
Alzheimers Dement. 2015 Oct;11(10):1163-70. doi: 10.1016/j.jalz. 2014.10.013. Epub 2014 Dec 9. PMID: 25499537

2014

Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition
Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, Akbarian S.
Neuron. 2014 Dec 3;84(5):997-1008. doi: 10.1016/j.neuron. 2014.10.032. Epub 2014 Nov 13. PMID: 25467983

A role for noncoding variation in schizophrenia
Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Brennand KJ, Robakis NK, Schadt EE, Akbarian S, Sklar P.
Cell Rep. 2014 Nov 20;9(4):1417-29. doi: 10.1016/j.celrep. 2014.10.015. Epub 2014 Nov 6. PMID: 25453756

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium.
Am J Hum Genet. 2014 Nov 6;95(5):535-52. doi: 10.1016/j.ajhg. 2014.10.004. Epub 2014 Nov 6. PMID: 25439723

The future of neuroepigenetics in the human brain
Mitchell A, Roussos P, Peter C, Tsankova N, Akbarian S.
Prog Mol Biol Transl Sci. 2014;128:199-228. doi: 10.1016/ B978-0-12-800977-2.00008-5. Review. PMID: 25410546

Myelination, oligodendrocytes, and serious mental illness
Haroutunian V, Katsel P, Roussos P, Davis KL, Altshuler LL, Bartzokis G.
Glia. 2014 Nov;62(11):1856-77. doi: 10.1002/glia.22716. Epub 2014 Jul 23. Review. PMID: 25056210

Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22. PMID: 25056061

A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide
Di Narzo AF, Kozlenkov A, Roussos P, Hao K, Hurd Y, Lewis DA, Sibille E, Siever LJ, Koonin E, Dracheva S.
Hum Mol Genet. 2014 Sep 15;23(18):4801-13. doi: 10.1093/hmg/ddu195. Epub 2014 Apr 29. PMID: 24781207

The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males
Koiliari E, Roussos P, Pasparakis E, Lencz T, Malhotra A, Siever LJ, Giakoumaki SG, Bitsios P.
Schizophr Res. 2014 Apr;154(1-3):42-7. doi: 10.1016/j.schres. 2014.02.017. Epub 2014 Mar 11. PMID: 24630139

Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
Roussos P, Haroutunian V.
Front Cell Neurosci. 2014 Jan 21;8:5. doi: 10.3389/fncel.2014.00005. eCollection 2014. Review. PMID: 24478629

A polygenic burden of rare disruptive mutations in schizophrenia
Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O’Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P.
Nature. 2014 Feb 13;506(7487):185-90. doi: 10.1038/nature12975. Epub 2014 Jan 22. PMID: 24463508

De novo mutations in schizophrenia implicate synaptic networks
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O’Donovan MC.
Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22. PMID: 24463507

Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK.
Mol Psychiatry. 2014 Feb;19(2):168-74. doi: 10.1038/mp.2013.166. Epub 2013 Dec 17. PMID: 24342994

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
Kozlenkov A, Roussos P, Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo AF, Hurd YL, Koonin EV, Dracheva S.
Nucleic Acids Res. 2014 Jan;42(1):109-27. doi: 10.1093/nar/gkt838. Epub 2013 Sep 20. PMID: 24057217

2013

Cognitive and personality analysis of startle reactivity in a large cohort of healthy males
Giakoumaki SG, Roussos P, Tsapakis EM, Koiliari E, Pasparakis E, Zouraraki C, Bitsios P.
Biol Psychol. 2013 Dec;94(3):582-91. doi: 10.1016/j.biopsycho. 2013.09.005. Epub 2013 Sep 16. PMID: 24051230

Schizoid personality disorder
Triebwasser J, Chemerinski E, Roussos P, Siever LJ.
J Pers Disord. 2012 Dec;26(6):919-26. doi: 10.1521/pedi. 2012.26.6.919. Review. PMID: 23281676

Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia
Roussos P, Katsel P, Davis KL, Giakoumaki SG, Lencz T, Malhotra AK, Siever LJ, Bitsios P, Haroutunian V.
Neuropsychopharmacology. 2013 Feb;38(3):533-9. doi: 10.1038/npp.2012.215. Epub 2012 Nov 7. Erratum in: Neuropsychopharmacology. 2013 Mar;38(4):699. Lencz, Todd [added]; Malhotra, Anil K [added]. PMID: 23132271

Sub-optimal parenting is associated with schizotypic and anxiety personality traits in adulthood
Giakoumaki SG, Roussos P, Zouraraki C, Spanoudakis E, Mavrikaki M, Tsapakis EM, Bitsios P.
Eur Psychiatry. 2013 May;28(4):254-60. doi: 10.1016/j.eurpsy. 2012.07.002. Epub 2012 Oct 10. PMID: 23062835

2012

Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy
Hazlett EA, Collazo T, Zelmanova Y, Entis JJ, Chu KW, Goldstein KE, Roussos P, Haznedar MM, Koenigsberg HW, New AS, Buchsbaum MS, Hershowitz JP, Siever LJ, Byne W.
Schizophr Res. 2012 Nov;141(2-3):119-27. doi: 10.1016/j.schres. 2012.08.022. Epub 2012 Sep 18. PMID: 22995934

CACNA1C as a risk factor for schizotypal personality disorder and schizotypy in healthy individuals
Roussos P, Bitsios P, Giakoumaki SG, McClure MM, Hazlett EA, New AS, Siever LJ.
Psychiatry Res. 2013 Mar 30;206(1):122-3. doi: 10.1016/j.psychres. 2012.08.039. Epub 2012 Sep 15. No abstract available. PMID: 22985546

Schizotypal personality disorder
Chemerinski E, Triebwasser J, Roussos P, Siever LJ.
J Pers Disord. 2013 Oct;27(5):652-79. doi: 10.1521/pedi_ 2012_26_053. Epub 2012 Aug 28. PMID: 22928856

Paranoid personality disorder
Triebwasser J, Chemerinski E, Roussos P, Siever LJ.
J Pers Disord. 2013 Dec;27(6):795-805. doi: 10.1521/pedi_ 2012_26_055. Epub 2012 Aug 28. Review. PMID: 22928850

A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples
Roussos P, Katsel P, Davis KL, Siever LJ, Haroutunian V.
Arch Gen Psychiatry. 2012 Dec;69(12):1205-13. doi: 10.1001/ archgenpsychiatry.2012.704. PMID: 22868662

Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study
Jutras-Aswad D, Jacobs MM, Yiannoulos G, Roussos P, Bitsios P, Nomura Y, Liu X, Hurd YL.
PLoS One. 2012;7(6):e39243. doi: 10.1371/journal.pone.0039243. Epub 2012 Jun 22. PMID:22745721

Transcription factor 4 as an important determinant of gating function in schizophrenia
Roussos P.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5915-6. doi:10.1073/pnas. 1203675109. Epub 2012 Apr 5. No abstract available. PMID: 22492968

Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
Roussos P, Katsel P, Davis KL, Bitsios P, Giakoumaki SG, Jogia J, Rozsnyai K, Collier D, Frangou S, Siever LJ, Haroutunian V.
Arch Gen Psychiatry. 2012 Jan;69(1):7-15. doi: 10.1001/archgenpsychiatry. 2011.110. Epub 2011 Sep 5. PMID: 21893642

2011

Sustained attention and working memory deficits follow a familial pattern in schizophrenia
Giakoumaki SG, Roussos P, Pallis EG, Bitsios P.
Arch Clin Neuropsychol. 2011 Nov;26(7):687-95. doi: 10.1093/arclin/acr060. Epub 2011 Aug 3. PMID: 21813556

The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
Roussos P, Giakoumaki SG, Georgakopoulos A, Robakis NK, Bitsios P.
Bipolar Disord. 2011 May;13(3):250-9. doi: 10.1111/j.1399-5618. 2011.00924.x. PMID: 21676128

Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia
Bitsios P, Roussos P.
Pharmacogenomics. 2011 Apr;12(4):559-66. doi: 10.2217/pgs.10.206 PMID: 21521027

The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males
Roussos P, Giakoumaki SG, Adamaki E, Georgakopoulos A, Robakis NK, Bitsios P.
Neuropsychopharmacology. 2011 Jul;36(8):1677-88. doi: 10.1038/npp.2011.49. Epub 2011 Apr 6. Erratum in: Neuropsychopharmacology. 2011 Oct;36(11):2370. Anastasios, Georgakopoulos [corrected to Georgakopoulos, Anastasios]; Nikos, Robakis K [corrected to Robakis, Nikos K]. PMID: 21471957

Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia
Katsel P, Byne W, Roussos P, Tan W, Siever L, Haroutunian V.
Neuropsychopharmacology. 2011 May;36(6):1171-7. doi: 10.1038/npp.2010.252. Epub 2011 Jan 26. PMID: 21270770

The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males
Roussos P, Giakoumaki SG, Adamaki E, Bitsios P.
Biol Psychiatry. 2011 Mar 1;69(5):479-86. doi: 10.1016/j.biopsych. 2010.09.009. Epub 2010 Oct 30. PMID: 21035784

2010

Cognitive and emotional processing associated with the Season of Birth and dopamine D4 receptor gene
Roussos P, Giakoumaki SG, Bitsios P.
Neuropsychologia. 2010 Nov;48(13):3926-33. doi: 10.1016/j.neuropsychologia. 2010.09.021. Epub 2010 Sep 25. PMID: 20875435

Low baseline startle and deficient affective startle modulation in remitted bipolar disorder patients and their unaffected siblings
Giakoumaki SG, Bitsios P, Frangou S, Roussos P, Aasen I, Galea A, Kumari V.
Psychophysiology. 2010 Jul 1;47(4):659-68. doi: 10.1111/j.1469- 8986.2010.00977.x. Epub 2010 Mar 11. PMID: 20233338

2009

Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism
Roussos P, Giakoumaki SG, Bitsios P.
Biol Psychiatry. 2009 Dec 1;66(11):997-1004. doi: 10.1016/j.biopsych.2009.07.008. Epub 2009 Aug 22. PMID: 19699472

Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype
Roussos P, Giakoumaki SG, Bitsios P.
Neuropsychologia. 2009 Jun;47(7):1654-9. doi: 10.1016/ j.neuropsychologia.2009.02.005.Epub 2009 Feb 11.PMID: 19397860

Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers
Koudas V, Nikolaou A, Hourdaki E, Giakoumaki SG, Roussos P, Bitsios P.
Psychopharmacology (Berl). 2009 Jul;205(1):1-9. doi: 10.1007/s00213-009-1508-5. Epub 2009 Mar 14. PMID: 19288084

A risk PRODH haplotype affects sensorimotor gating, memory, schizotypy, and anxiety in healthy male subjects
Roussos P, Giakoumaki SG, Bitsios P.
Biol Psychiatry. 2009 Jun 15;65(12):1063-70. doi: 10.1016/ j.biopsych.2009.01.003. Epub 2009 Feb 20. PMID: 19232576

Azoles and antidepressants: a mini-review of the tolerability of co-administration
Roussos P, Lewis RE, Kontoyiannis DP.
Mycoses. 2009 Sep;52(5):433-9. doi: 10.1111/j.1439-0507.2008. 01677.x. Epub 2009 Jan 21. Review. PMID: 19207836

2008

Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
Giakoumaki SG, Roussos P, Bitsios P.
Neuropsychopharmacology. 2008 Dec;33(13):3058-68. doi: 10.1038/npp.2008.82. Epub 2008 Jun 4. PMID: 18536698

The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex
Roussos P, Giakoumaki SG, Bitsios P.
Biol Psychiatry. 2008 Aug 1;64(3):235-40. doi: 10.1016/j.biopsych. 2008.01.020. Epub 2008 Mar 5. PMID: 18325483

Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism
Roussos P, Giakoumaki SG, Rogdaki M, Pavlakis S, Frangou S, Bitsios P.
Psychol Med. 2008 Nov;38(11):1651-8. doi: 10.1017/ S0033291708002912. Epub 2008 Feb 8. PMID: 18261249

Planning, decision-making and the COMT rs4818 polymorphism in healthy males
Roussos P, Giakoumaki SG, Pavlakis S, Bitsios P.
Neuropsychologia. 2008 Jan 31;46(2):757-63. Epub 2007 Oct 22. PMID: 18037454

The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apnea
Nikolaou A, Schiza SE, Giakoumaki SG, Roussos P, Siafakas N, Bitsios P.
Psychopharmacology (Berl). 2008 Feb;196(2):167-75. Epub 2007 Sep 25. PMID: 17899016

2007

Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy males
Giakoumaki SG, Roussos P, Frangou S, Bitsios P.
Psychopharmacology (Berl). 2007 Oct;194(3):289-95. Epub 2007 Jun 20. PMID: 17579840

Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patients
Giakoumaki SG, Roussos P, Rogdaki M, Karli C, Bitsios P, Frangou S.
Biol Psychiatry. 2007 Dec 15;62(12):1418-22. Epub 2007 May 3. PMID: 17481589