Natural products in drug discovery
July 31, 2024
By Jessica Robinson-Papp, MD MS At the PAIRED project we are deeply involved in efforts to develop new non-addictive treatments for chronic pain. We participate in just one step in this long drug discovery process, the so-called “phase 2” and “phase 3” clinical trials…
From pathogens to paralysis: understanding the impact of infectious neuropathies
Apr 8, 2024
By Mitali Mehta, PhD(c) Within the complex terrain of human health, the intersection between infectious diseases and neurological outcomes represents a realm often overlooked. Often we compartmentalize diseases into tidy categories, focusing on the primary symptoms while…
Beyond digestion: how does our gut microbiome shape the symphony of human health?
By Mitali Mehta, PhD(c) In the intricate tapestry of human physiology, the gut microbiome emerges as a web of molecular strands, each thread contributing to the orchestration of our well-being. As researchers, our journey resembles that of meticulous cartographers, mapping…
Autonomic control of the immune system
By Jessica Robinson-Papp, MD MS Last month we were excited to have a new manuscript published online in the Journal of Neuroimmune Pharmacology exploring how dysfunction of the autonomic nervous system (ANS) might impact immune function. It’s been known for a long time that the sympathetic nervous…
Opioids and chronic pain
Sep 22, 2023
By Jessica Robinson-Papp, MD MS One of our PAIRED project research studies, called TOWER, studied how best to implement the CDCs opioid prescribing guidelines in the HIV primary care clinic. We started the study because when the original guidelines came out back in 2016 we…
On cultural competence and hospitality
Jul 24, 2023
By Jessica Robinson-Papp, MD MS This past week I’ve been reading about Diversity, Equity and Inclusion (DEI) initiatives in academic medicine and I keep running across the term “cultural competence.” It’s one of those terms that I think I know the meaning of but if I stop to…
When leaving home is hard
Jul 7, 2023
By Bridget Mueller, MD PhD. The PAIRED Project team is always excited to meet new research participants. Usually, our research coordinators have spent a lot of time talking to them in advance and planning out the details of the visit over multiple phone calls. But…
The long term effects of autonomic neuropathy in people living with HIV
Jun 23, 2023
By Jessica Robinson-Papp, MD MS This month our manuscript “Autonomic neuropathy as a predictor of morbidity and mortality in people living with HIV: a retrospective, longitudinal cohort study” was published in Neurology Clinical Practice. The title kind of says it all, we found that autonomic…
Nothing about us without us
By Jessica Robinson-Papp, MD MS Every Thursday afternoon, I meet with my collaborator and friend, Dr. Monica Rivera Mindt. Dr. Monica Rivera Mindt. Dr. Rivera Mindt is a community engaged researcher who has spent decades living and working in the Harlem neighborhood…
Why is research important to me?
May 25, 2023
By Mary Catherine George, PhD The eternal question my family and friends ask me is, “Why are you involved in scientific research for pain treatments?” My first career was as a professional opera singer. My journey into scientific research was accidental. I loved…
How do we get the new pain medicines we need?
May 19, 2023
By Jessica-Robinson-Papp, MD MS The last several years have been an exciting time for pain research, as the tragedy of the U.S. opioid epidemic funneled attention and resources toward efforts to find new, non-addictive pain treatments. We’ve all seen the numbers, millions and millions of Americans with chronic pain, and few if any safe and effective treatments. There’s an old observation among researchers that common diseases are common until you try to study them, then…
More than just a headache
May 12, 2023
By Jessica Robinson-Papp, MD MS As neurologists, headache is one of the pain disorders we see most often, especially Dr. Mueller who is a headache specialist. Most patients with headache have episodic symptoms and go back to feeling normal between attacks. But some suffer from headaches…
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