PAIRED Project: Pain, Autonomics, and Immune Research in Diverse Populations
EPPIC-Net
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
NIH U24 NS113849
EPPIC-Net (Early Phase Pain Investigation Clinical Network) is a consortium of centers with the shared goal of accelerating development of non-addictive treatments for pain. As a site in this consortium, Mount Sinai offers patients participation in these clinical trials. Interested patients can sign up to be part of our registry and we’ll contact them if we have a trial that’s right for them.
To join the pain registry click here.
Currently we have open clinical trails for pain related to knee osteoarthritis and painful diabetic peripheral neuropathy (PDPN), learn more here.
If you are interested in participating in either clinical trial, we’d love to speak to you! Call us at 212-241-0190, or email us at paired.project@mssm.edu.
EVA
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
NIH R01DK122853
The autonomic nervous system, including the vagus nerve, is an important controller of immune function, and our prior research has shown that vagal dysfunction is linked to small intestinal bacterial overgrowth (SIBO) and signs of inflammation in the blood of people living with HIV.
The EVA project explores pathways linking autonomic dysfunction to inflammation in people living with HIV compared to people without HIV, focusing on the gastrointestinal tract. We are also testing whether a drug, pyridostigmine, which can increase levels of the vagus nerves’ neurotransmitter, acetylcholine, and non-invasive vagal nerve stimulation are beneficial.
Read the recruitment brochure.
Global HIV Pain Task Force
The Global HIV Pain Task Force is a group of researchers and people with lived experience from the United States, United Kingdom, Canada and South Africa. We study, treat and live with chronic pain and HIV, and are passionately committed to finding the safe and effective treatments we desperately need. Our current project is a survey to understand the research priorities and lived experience of people living with HIV and chronic pain.
SALUD
Study of Aging Latinas/os for Understanding Dementia in HIV
NIH R01AG065110
This project investigates whether older Latinx individuals show worse patterns of decline in cognition and brain integrity compared to other groups and seeks to understand the mechanisms conferring risk for these changes. Learn more here.
TOWER
Toward safer opioid prescribing for chronic pain in high risk populations: implementing the Centers for Disease Control Guideline (CDC) guideline in the primary care HIV clinic.
AHRQ R18 HS025641
The TOWER study is now complete! It’s purpose was to determine the best way of supporting HIV primary care providers in adopting safer opioid prescribing practices. Read the results:
Contact Us
PAIRED Project
paired.project@mssm.edu
212-241-0190