EVA
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
NIH R01DK122853
The autonomic nervous system, including the vagus nerve, is an important controller of immune function, and our prior research has shown that vagal dysfunction is linked to small intestinal bacterial overgrowth (SIBO) and signs of inflammation in the blood of people living with HIV.
The EVA project explores pathways linking autonomic dysfunction to inflammation in people living with HIV compared to people without HIV, focusing on the gastrointestinal tract. We are also testing the effects of a drug, pyridostigmine, which can increase levels of the vagus nerves’ neurotransmitter, acetylcholine, and non-invasive vagal nerve stimulation.
NEIGHBOR
Network for Integrated Health and Brain-Oriented Research
The National Institutes of Health funds multiple brain health studies at the Department of Neurology at Mount Sinai in order to understand and treat different neurological conditions. The NEIGHBOR survey aims to create a network of patients interested in participating in observational studies or clinical trials related to brain health or different types of neurological conditions. The study, linked below, is actively recruiting those who would like to be contacted for clinical trials and research studies for which they are deemed eligible.
EPPIC-Net
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
NIH U24 NS113849
EPPIC-Net (Early Phase Pain Investigation Clinical Network) is a consortium of centers with the shared goal of accelerating the development of non-addictive treatments for pain. As a site in this consortium, Mount Sinai offered patients participation in these clinical trials for people with painful diabetic peripheral neuropathy (PDPN). As the study has completed recruitment, we are now looking forward to the results while expecting new opportunities for diabetic PN research in the future.
SALUD
Study of Aging Latinas/os for Understanding Dementia in HIV
NIH R01AG065110
This project investigated brain health disparities in older Black and Latino adults. Recruitment was completed in the Spring of 2025, and we are now awaiting results.
GLOBAL HIV PAIN TASK FORCE
Global HIV Pain Task Force
The Global HIV Pain Task Force is a group of researchers and people with lived experience from the United States, United Kingdom, Canada and South Africa. We study, treat and live with chronic pain and HIV, and are passionately committed to finding the safe and effective treatments we desperately need.
TOWER
Toward safer opioid prescribing for chronic pain in high-risk populations: implementing the Centers for Disease Control Guideline (CDC) guideline in the primary care HIV clinic.
AHRQ R18 HS025641
The TOWER study is complete! Its purpose was to determine the best way of supporting HIV primary care providers in adopting safer opioid prescribing practices and the results are linked below.
PAIRED Project
paired.project@mssm.edu
212-241-0190