Our lab seeks to identify the underpinnings of cancer and to use this information to improve cancer prevention and treatment.  We employ a multidisciplinary approach to study cancer by combining molecular pathology and genetic studies of human tumor biopsies, human and mouse tumor models, metabolism, epigenetics, and biochemistry of signaling. Our research is particularly focused on the mechanisms through which the PTEN/PI3K pathway is altered in cancer and the consequences of its alteration. Our disease focus is solid tumors with a particular emphasis on breast cancer.