Selected Publications

Kotini AG, Carcamo S, Cruz-Rodriguez N, Olszewska M, Wang T, Demircioglu D, Chang, C-J, Bernard E, Chao MP, Majeati R, Luo H, Kharas MG, Hasson D, Papapetrou EP*.
Patient-derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia.
Blood Cancer Discov. In Press
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Wheeler EC^$, Vora S^$, Mayer D, Kotini AG, Olszewska M, Park SS, Guccione E, Teruya-Feldstein J, Silverman L, Sunahara RK, Yeo GW*, Papapetrou EP*.
Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms.
Cancer Discovery 2022; 12:836-855.
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Wang T^$, Pine AR^$, Kotini AG, Yuan H, Zamparo L, Starczynowski DT, Leslie C*, Papapetrou EP*.
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.
Cell Stem Cell 2021; 28: 1074-1089.
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Papapetrou EP. 
Modeling Leukemia with Human Induced Pluripotent Stem Cells. 
Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a034868. doi: 10.1101/cshperspect.a034868.
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Kotini AG, Chang CJ, Chow A, Yuan H, Ho TC, Wang T, Vora S, Solovyov A, Husser C, Olszewska M, Teruya-Feldstein J, Perumal D, Klimek VM, Spyridonidis A, Rampal RK, Silverman L, Reddy EP, Papaemmanuil E, Parekh S, Greenbaum BD, Leslie CS, Kharas MG, Papapetrou EP.
Stage-specific human induced pluripotent stem cells map the progression of myeloid transformation to transplantabe leukemia.
Cell Stem Cell 2017;20(3):315-328. 
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Papapetrou EP.
Patient-derived induced pluripotent stem cells in cancer research and precision oncology.
Nat Med. 2016;22(12):1392-1401.
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Papapetrou EP.
Induced pluripotent stem cells, past and future. 
Science 2016; 353 (6303): 991-992.
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Kotini AG, Chang CJ, Boussaad I, Delrow JJ, Dolezal EK, Nagulapally A, Perna F, Fishbein GA, Klimek VM, Hawkins DR, Huangfu D, Murry CE, Graubert T, Nimer SD, Papapetrou EP.
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells. 
Nature Biotechnology 2015;33(6):646-55. 
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