Studying Blood Cancers with Human Induced

Pluripotent Stem Cells

We study malignant and pre-malignant disorders of hematopoiesis (myelodysplastic syndrome, MDS; myeloproliferative neoplasms, MPN; acute myeloid leukemia, AML) with human induced pluripotent stem cell (iPSC) models and primary patient cells.

We use somatic cell reprogramming and CRISPR-mediated genome editing technologies to develop human pluripotent stem cell models of blood diseases, with which we investigate disease mechanisms and seek to identify new therapeutic targets.

We are located in the Leon and Norma Hess Center for Science and Medicine at Icahn School of Medicine at Mount Sinai.