Millar Lab

Welcome to the Millar lab

Our research focuses on cell-cell signaling and epigenetic mechanisms controlling development, stem cell function and regeneration of epithelial organs including the skin epidermis and ectodermal appendages such as hair follicles, mammary glands, taste papillae and teeth. We use genetic mouse models and patient-derived and gene edited iPS cells to model human genetic skin disease and test novel therapeutic approaches. Current projects in the lab include testing new approaches to treat human ectodermal dysplasia; defining the mechanisms that control formation and maintenance of hairless versus hairy skin; and delineating the functions of histone deacetylases that modify chromatin developing, and regenerating skin and in skin cancer.

The Millar lab is part of the Black Family Institute; the Department of Cell, Regenerative and Developmental Biology; and the Department of Dermatology. Dr. Millar is also a faculty member of the Development, Regeneration and Stem Cells (DRS) graduate program.

Rotation projects

1. Investigate mechanisms that cause ectodermal dysplasia in patients with mutations in the WNT10A gene using patient-derived and gene-edited induced pluripotent stem cells (iPS) and test potential therapeutic strategies.

2. Determine the mechanisms that underlie the formation and maintenance of hairy versus hairless skin and regulate hair patterning using genetic mouse models.

3. Define the functions of histone deacetylase chromatin modifiers in skin development, stem cells and cancer.

4. Identify pioneer transcription factors that control development and stem cell activity in skin and oral epithelia.

 

If you are interested in a rotation project or position in the Millar lab please contact Dr. Millar at sarah.millar@mssm.edu.

Sarah E. Millar, Ph.D.
Director, Black Family Stem Cell Institute
Professor, Departments of Cell, Developmental and Regenerative Biology and Dermatology
Icahn School of Medicine at Mount Sinai
Icahn Building, Floor 13 Room 020C
1425 Madison Ave
New York, NY 10029
Tel: (212) 659-9412
Email: sarah.millar@mssm.edu

Taylor Stokelin, MHA Administrative Coordinator
Black Family Stem Cell Institute
Icahn School of Medicine at Mount Sinai
Icahn Building, Floor 13 Room 70E, Box 1496
1425 Madison Ave
New York, N.Y. 10029
Tel: 212-659-9438 (ext: 89438)
Cell: 646-907-4242
Taylor.stokelin@mssm.edu
New York, NY 10029
Tel: (212) 659-9412
Email: sarah.millar@mssm.edu

Maya Fridrikh
Research Laboratory Manager, Millar lab
Technical Director, Black Family Stem Cell Institute
1425 Madison Ave, Floor 13 Room 20
Desk: (212)-659-6897
Cell: (646)-581-8011