Selected Publications

Uzzan M., Tokuyama M., Rosenstein A.K., Tomescu C., SahBandar I.N., Ko H.M., Leyre L., Chokola A., Kaplan-Lewis E., Rodriguez G., Seki A., Corley M.J., Aberg J., La Porte A., Park E., Ueno H., Oikonomou I., Doron I., Iliev I.D., Chen B.K., Lui J., Schacker T.W., Furtado G.C., Lira S.A., Colombel J.F., Horowitz A., Lim J.K., Chomont N., Montaner L.J., Ndhlovu L.C., and Mehandru S. Anti-47 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals. 2018. Science Translational Medicine. 2018. PMID: 32082696.

Shan M, Carrillo J, Yeste A, Gutzeit C, Garzon DS, Wallland C, Pybus M, Yeiser JR, Matthews DB, Van de Veen W, Comerma L, He B, Boonpiyathad T, Lee H, Blanco J, Osborne LC, Siracusa MC, Akdis M, Artis D, Mehandru S, Sampson HA, Berin C, Chen K, Cerutti A. Secreted IgD amplifies humoral TH2 responses by binding basophils though the CD44-interacting protein galectin-9. Immunity. 2018. PMID: 30291028

Magri G, Comerma L, Pybus M, Sintes J, Lilge D, Segua-Garzon D, Bascones S, Yeste A, Grasset E, Gutzeit C, Uzzan M, Ramanujam M, Van Zelm MC, Albero-Gonzalez R, Vazquez I, Iglesias M, Serrano S, Marquez L, Mercade E, Mehandru S and Cerutti A. Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals coated by secretory IgA. Immunity. 2017. PMID: 28709802

Uzzan M, Ko H, Rosenstein A, Pourmand K, Colombel JF and Mehandru S. Efficient long-term depletion of CD20+ B cells by Rituximab does not affect gut-resident plasma cells. Ann N Y Acad Sci. 2017. PMID 29291255

Torres J, Mehandru S, Allen PB, Colombel JF, Peyrin-Biroulet L. Crohn’s Disease. Lancet. 2017. PMID: 27914655

Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative Colitis. Lancet. 2017. PMID: 27914657

Markowitz M, Deren S, Cleland C, LaMar M, Silva E, Batista P, St. Bernard L, Gettie N, Rodriguez K, Evering TH, Lee H and Mehandru S. Chronic hepatitis C infection and the pro-inflammatory effects of injection drug use. Journal of Infectious Diseases. 2016. PMID: 27521361

Ruane DT, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein E, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A and Mehandru S. Microbiota regulate the ability of lung dendritic cells to induce IgA class switch recombination and generate protective GI immune responses. J. Exp. Med. 2015 Dec 28. pii: jem.20150567. PMID: 26712806

Ruane DT, Do Y, Brane L, Garg A, Bozzacco L, Kraus T, Caskey M, Salazar A, Trumpfheller C and Mehandru S. A Dendritic cell targeted vaccine induces long term HIV-specific immunity within the gastrointestinal tract. Mucosal Immunol. 2016 Jan 6. doi: 10.1038/mi.2015.133. PMID: 26732678

* Lee H, Ruane DT, Law K, Ho Y, Garg A, Rahman A, Esterhazy D, Cheong C, Goljo E, Sikora A, Mucida D, Chen B, Govindraj S, Breton G and Mehandru S. Phenotype and function of nasal dendritic cells. Mucosal Immunol. 2015 Sep;8(5):1083-98. PMID 25669151

*Journal Cover

Ho TH, Cohen B, Colombel JF and Mehandru S. Review article: The intersection of mucosal pathophysiology in HIV and inflammatory bowel disease and its implications for therapy. Aliment Pharmacol Ther. 2014 Nov;40(10):1171-86. PMID: 25267394

Anandasabapathy N, Feder R, Mollah S, Tse, Sze-Wah, Longhi MP, Mehandru S, Matos I, Cheong C, Ruane D, Brane L, Teixeira A, Dobrin JS, Mizenina O, Meredith, MM, Clausen BE, Nussenzweig, MC and Steinman RM. Classical Flt3L-dependent dendritic cells control immunity to protein vaccine. J Exp Med. 2014 Aug; 211(9):1875-91 PMID: 25135299

Ruel J, Ruane DT, Mehandru S, Gower-Rousseau C and Colombel JF. Inflammatory Bowel Disease Across Ages: Is It The Same Disease? Nature Reviews Gastroenterology and Hepatology. 2014 Feb;11(2):88-98. PMID: 24345891

Evering TH, Mehandru S, Racz P, Tenner-Racz K, Poles MA, et al. Absence of HIV-1 Evolution in the Gut-Associated Lymphoid Tissue from Patients on Combination Antiviral Therapy Initiated during Primary Infection. PLoS Pathog. 2012 Feb;8(2): e1002506. PMID: 22319447

Choi J-H, Cheong C, Dandamudi D, Park CG, Rodriguez A, Mehandru S, Velinzon K, Jung I-H, Yoo J-Y, Oh GT and Steinman RM. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Immunity. 2011 Nov 23;35(5):819-31. PMID: 22078798

Do Y, Koh H, Park CG, Dudziak D, Seo P, Mehandru S, Choi J-H, Cheong C, Park S, Perlin DS, Powell BS and Steinman RM. Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Eur J Immunol 2010 Oct;40(10):2791-6. PMID: 20812236

Mehandru S, Vcelar B, Wrin T, Stiegler G, Joos B, Mohri H, Boden D, Galovich J, Tenner-Racz K, Racz K, Carrington M, Petropoulos P, Katinger H, Markowitz M. Adjunctive passive immunotherapy in HIV-1-infected individuals treated with antiviral therapy during acute/early infection. J Virol. 2007 Oct;81(20):11016-31. PMID: 17686878

Bozzacco L, Trumpfheller C, Siegal FP, Mehandru S, Markowitz M, Piperno AG and Steinman RM. The DEC 205 receptor on dendritic cells mediates presentation of HIV-1 gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc  NatL Acad Sci USA. Jan 23;104(4):1289-94. PMID: 17229838

Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M. Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS Med. 2006 Dec;3(12):e484 PMID: 17147468

Mehandru S, Poles MA, Tenner-Racz K, Manuelli V, Jean-Pierre P, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M. Mechanisms of gastrointestinal CD4+ T cell depletion during acute and early HIV-1 infection. J Virol. 2007 Jan;81(2):599-612. PMID: 17065209

Mehandru S, Tenner-Racz K, Racz P and Markowitz M. The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection. J Allergy Clin Immunol. 2005; 116(2): 419-422. PMID: 16083799

Markowitz M, Mohri H, Mehandru S, Shet A, Berry L, Kalyanaraman R, Kim A, Chung C, Jean- Pierre P, Horowitz A, La Mar M, Wrin T, Parkin N, Poles M, Petropoulos C, Mullen M, Boden D and Ho D. Infection with multidrug resistant, dual tropic HIV-1 and rapid progression to AIDS: a case report. Lancet. 2005; 365: 1031-38. PMID: 15781098

Mehandru S, Wrin T, Galovich J, Stiegler G, Vcelar B, Hurley A, Hogan C, Vasan S, Katinger H, Petropoulos P, Markowitz M.  Neutralization profiles of newly transmitted HIV-1 by monoclonal antibodies 2G12, 2F5 and 4E10. J virol. 2004; 78: 14039-14042 2004. 15564511

Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, Boden D, Racz P and Markowitz M. Primary HIV-1 infection is associated with preferential depletion of CD4+ T cells from effector sites in the gastrointestinal tract. J Exp Med. 2004 Sep 20;200(6):761-70. PMID: 15365095