BaronLab-Publications-Fig1
Baron, M.H., Evans, D.R., and W.N. Lipscomb (1979) The Location and Local Environment of the Active Sites of Aspartate Transcarbamylase of Escherichia coli. J. Biol. Chem. 254: 10686-10693.

Das Gupta, A., Baron, M.H., and D. Baltimore (1979) Poliovirus replicase: A soluble enzyme able to initiate copying of poliovirus RNA. Proc. Natl. Acad. Sci. U.S.A. 76: 2679-2683.

Baron, M.H. and D. Baltimore (1982) Antibodies Against the Chemically Synthesized Genome-Linked Protein of Poliovirus React with Native Virus-Specific Proteins. Cell 28: 395-404.

Baron, M.H. and D. Baltimore (1982) Purification and Properties of a Host Cell Protein Required for Poliovirus Replication in Vitro. J.Biol. Chem. 257: 12351-12358.
Baron, M.H. and D. Baltimore (1982) In Vitro Copying of Viral Positive Strand RNA by Poliovirus Replicase: Characterization of the Reaction and its Products. J. Biol. Chem. 257: 12359-12366.

Baron, M.H. and D. Baltimore (1982) Antibodies Against a Synthetic Peptide of Poliovirus Replicase Protein: Reaction with Native, Virus-Encoded Proteins and Inhibition of Virus-Specific Polymerase Activities in Vitro J. Virol. 43: 969-978.

Baron, M.H. and D. Baltimore (1982) Anti-VPg Antibody Inhibition of the Poliovirus Replicase Reaction and Production of Covalent Complexes of VPg-Related Polypeptides and Newly-Made RNA. Cell 30: 745-752.

Baron, M.H. and T. Maniatis (1986) Rapid Reprogramming of Globin Gene Expression in Transient Heterokaryons. Cell 46: 591-602.

Baron, M.H. and T. Maniatis (1987) Stage-Specific Reprogramming of Globin Gene Expression. Progr. Clin. Biol. Res. 251: 271-284.

Baron, M.H. and T. Maniatis (1987) Reprogramming of Globin Gene Expression in Interspecific Heterokaryons. In Molecular Approaches to Developmental Biology, Alan R. Liss, Inc.,pp. 469-476.

Baron, M.H. and T. Maniatis (1991) Regulated Expression of Human a- and b-Globin Genes in Transient Heterokaryons. Mol. Cell. Biol. 11: 1239-1247.

Trepicchio, W.L., Dyer, M.A. and M.H. Baron (1993) Developmental regulation of the human embryonic b-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements, Mol. Cell. Biol. 13 : 7457-7468.

Baron, M.H. (1993) Reversibility of the Differentiated State in Somatic Cells. Current Opinion Cell Biol. 5: 1050-1056, Current Biology Ltd., London.

Baron, M.H. and S.M. Farrington (1994) Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells, Mol. Cell. Biol.14: 3108-3114.

Trepicchio, W.L., Dyer, M.A., and M.H. Baron (1994) A novel developmental regulatory motif required for stage-specific activation of the e-globin gene and nuclear factor binding in embryonic erythroid cells, Mol. Cell. Biol. 14: 3763-3771.

Trepicchio, W.L., Dyer, M.A., Hardison, R.C., and M.H. Baron (1994) Upstream regulatory region of the human embryonic b-like globin gene, e, DNA Sequence 4: 409-412.

Baron, M.H. (1994) Embryonic Erythroid Differentiation and Development. Symp. European School of Molec. Med. (Signal Transduction in Differentiation and Trans-Differentiation), Brescia, Italy.

Lister, J., Forrester, W.C., and M.H. Baron (1995) Inhibition of an erythroid differentiation switch by the helix-loop-helix protein, Id1. J. Biol. Chem. 270 : 17939-17946.

Dyer, M.A., W.L. Trepicchio, M. Belaoussoff, S.M. Farrington, and M.H. Baron (1995) Molecular Mechanisms of Embryonic b-Like Globin Gene Regulation During Mammalian Development. Hemoglobin Switching, vol. 1, Intercept Ltd., pp. 135-151.

Dyer, M.A., Naidoo, R., Hayes, P.J., Larson, C.J., Verdine, G.L. and M.H. Baron (1996) A DNA bending protein interacts with an essential upstream regulatory element of the human embryonic -like globin gene. Mol. Cell. Biol. 16: 829-838.

Baron, M.H. (1996) Developmental Regulation of the Vertebrate Globin Multigene Family. Gene Expression 6: 129-137.

Farrington, S.M., Belaoussoff, M. and M.H. Baron (1997) Winged helix, hedgehog, and Bmp genes are differentially restricted to functionally distinct tissue layers within the murine embryonic yolk sac. Mech. Develop. 62: 197-211.

Baron, M.H. (1997) Transcriptional control of globin gene expression during vertebrate development. Biochim. Biophys. Acta 1351: 51-72.

Lister, J. and M.H. Baron (1998) Induction of basic-helix-loop-helix protein-containing complexes during erythroid differentiation. Gene Expression 7: 25-38.

Dyer, M.A., Hayes, P.J., and M.H. Baron (1998) The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic b-like globin gene. Mol. Cell Biol. 18: 2617- 2628.

Belaoussoff, M., Farrington, S.M. and M.H. Baron (1998) Hematopoietic Induction and Respecification of A-P Identity by Visceral Endoderm Signaling in the Mouse Embryo. Development 125: 5009- 5018.

Spencer, J. A., Baron, M. H., and Olson, E. N. (1999) Cooperative Transcriptional Activation by Serum Response Factor and the High Mobility Group Protein SSRP1. J. Biol. Chem. 274: 15686-15693.

Baron, M.H. (2000) Interaction of endoderm and ectoderm in embryonic hematopoiesis. Exper. Hematol. 28: 129-.

Baron, M.H. (2001) Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis. In: L. Zon, ed. Hematopoiesis, Chapter 13, New York, Oxford University Press, pp. 160-170.

Dyer, M.A., Farrington, S.M., Mohn, D., Munday, J., and M.H. Baron (2001) Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128: 1717-1730.

Baron, M.H. (2001) Induction of Embryonic Hematopoietic and Endothelial Stem/Progenitor Cells by Hedgehog-Mediated Signals. Differentiation 69: 175-185.

Baron, M.H. (2001) Molecular Regulation of Embryonic Hematopoiesis and Vascular Development: A Novel Pathway. J. Hematother. Stem Cell Res. (now Stem Cells and Development) 10: 587- 594.

Baron, M.H. and Mitus, A.J. (2002) Chapter 15: Blood Disorders. In: K. Carlson and S.A. Eisenstadt, eds. Primary Care of Women, 2nd Ed., St. Louis, Mosby-Year Book, Inc., pp. 142-150.

Sahr, K., Dias, D., Sanchez, R., Chen, D., Chen, S., Gudas, L. and M.H. Baron (2002). Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene. Gene 291: 135-147.

Baron, M.H. (2002) Activation of Hematopoiesis and Vasculogenesis in the Mouse Embryo: Induction and Reprogramming of Ectodermal Cell Fate by Signals from Primitive Endoderm. In: Eaton, G.R., Wiley, D.C., and Jardetsky, O., eds. Structures and Mechanisms: From Ashes to Enzymes (ACS Symposium Series), Vol. 827 (Washington, DC, American Chemical Society), pp. 294-308.

Jones, E.A.V., D. Crotty, P. Kulesa, C.W. Waters, M.H. Baron, S.E. Fraser, M.E. Dickinson (2002) Dynamic In Vivo Imaging of Post-Implantation Mammalian Embryos Using Whole Embryo Culture. Genesis 34: 228-235.

Mohn, D., Chen, S., Dias, D., Weinstein, D., Dyer, M.A., Sahr, K., Ducker, C.E., Zahradka, K.E., Keller, G., Zaret, K.S., Gudas, L. and M.H. Baron (2003) The mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Developmental Dynamics 226: 446-459.

Baron, M.H. (2003) Embryonic Origins of Mammalian Hematopoiesis. Experimental Hematology, 31: 1160-1169.

Baron, M.H. (2004) Hemangioblasts in Adults? [“Inside Blood,” invited commentary] Blood 103: 1.

Jones, E.A.V., Baron, M.H., Fraser, S.E., and Dickinson, M.E. (2004) Measuring Hemodynamic Changes During Mammalian Development. Amer. J. Physiol. 287: H1561-H1569.

Snyder, A., Fraser, S.T., and Baron, M.H. (2004) Bone Morphogenetic Proteins in Vertebrate Hematopoietic Development. J. Cellular Biochem. 93: 224-232. Cover article.

Baron, M.H. (ed.) (2005) Developmental Regulation of Hematopoiesis: Methods and Protocols. Methods in Molecular Medicine series, New York, Humana Press.
• This publication was highlighted in a review by de Bruijn, M. (2005) Developmental hematopoiesis from fly to human. Development 132: 5128-5130.

Jones, E.A.V., Crotty, D., Baron, M.H., Fraser, S.E. and Dickinson, M.E. (2005) Dynamic In Vivo Imaging of Mammalian Hemato-Vascular Development Using Whole Embryo Culture. Developmental Regulation of Hematopoiesis: Methods and Protocols, ed. Baron, M.H., Methods in Molecular Medicine series, New York, Humana Press, pp. 381-393.

Baron, M.H. and Mohn, D. (2005) Mouse Embryonic Explant Culture System for Analysis of Hematopoietic and Vascular Development. In Developmental Regulation of Hematopoiesis: Methods and Protocols, ed. Baron, M.H., Methods in Molecular Medicine series, New York, Humana Press, pp. 231-256.

Baron, M.H. and Fraser, S.T. (2005) The Specification of Early Hematopoiesis in the Mammal. I. Lemischka, ed. Current Opinion in Hematology 12: 217-221.

Fraser, S.T., Hadjantonakis, K., Willey, S., Sahr, K.E., Kelly, O.G., Jones, E.A.V., Dickinson, M.E., and Baron, M.H. (2005) Using a Histone Yellow Fluorescent Protein Fusion for Tagging and Tracking Endothelial Cells in ES Cells and Mice. Genesis 42: 162-171.

Baron, M.H. (2005) Early Patterning of the Mouse Embryo: Implications for Hematopoietic Commitment and Differentiation. Experimental Hematology 33: 1015-1020.

Willey, S., Ayuso-Sacido, A., Zhang, H., Fraser, S.T., Adlam, M.A., Sahr, K., Kyba, M., Daley, G.Q., Keller, G., and Baron, M.H. (2006) Acceleration of Mesoderm Development and Expansion of Hematopoietic Progenitors in Differentiating ES Cells by the Mouse Mix-Like Homeodomain Transcription Factor. Blood 107: 3122-3130. First Edition Paper, January 10, 2006; DOI 10.1182/blood-2005-10-4120. PMCID: PMC1784910

Kwon, G., Fraser, S.T., Eakin, G., Mangano, M., Isern, J., Sahr, K.E., Hadjantonakis, A.-K., and Baron, M.H. (2006) Tg(Afp-GFP) Expression Marks Primitive and Definitive Endoderm Lineages during Mouse Development. Developmental Dynamics 235: 2549-2558. Epub ahead of press.

Fraser, S.T., Isern, J. and Baron, M.H. (2007) Maturation and enucleation of primitive erythroblasts is accompanied by changes in cell surface antigen expression patterns during mouse embryogenesis. Blood 109: 343-352. First Edition Paper, August 29, 2006; DOI 10.1182/blood- 2006-03-006569.

Haremaki, T., Fraser, S.T., Kuo, Y.-M., Baron, M.H., and Weinstein, D.C. (2007) Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 104: 12029-12034. Early Edition, 10.1073_pnas0701413104.

Durand, C., Robin, C., Bollerot, K., Baron, M.H., Ottersbach, K., and Dzierzak, E. (2007) Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells, Proc. Natl. Acad. Sci. U.S.A. 104: 20838-20843.
Baron, M.H. (2008) The wanderings of hematopoietic stem cells. Blood 111: 3307-3308 [“Inside Blood,” invited commentary].

Isern, J., Fraser, S.T., He, Z. and Baron, M.H. (2008) The fetal liver is a niche for maturation of primitive erythroid cells. Proc. Natl. Acad. Sci. U.S.A. 105: 6662-6667. [Also see “This Week in PNAS/In This Issue”]

Larina, I.V., Shen, W., Kelly, O.G., Hadjantonakis, A.-K., Baron, M.H., and Dickinson, M.E. (2009) A membrane associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development. The Anatomical Record 292: 333-3341.

Fraser, S.T. and Baron, M.H. (2009) Embryonic fates for extraembryonic lineages: new perspectives. J. Cellular Biochem., 107: 586-591.

Zhang, H., Fraser, S.T., Papazoglu, C., Hoatlin, M.E., and Baron, M.H. (2009) The Mouse Mesendoderm Gene Goosecoid is a Transcriptional Target of the Mixl1 Homeodomain Protein in Differentiating Embryonic Stem Cells. Stem Cells 27: 2884-2895. [Epub ahead of print] PMID: 19711456.

Isern, J., Fraser, S.T., He, Z. and Baron, M.H. (2010) Developmental niches for embryonic erythroid cells. Blood Cells, Molecules and Diseases 44: 207-208, DOI 10.1016/j.bcmd.2010.02.008. PMCID: PMC2846976.

Fraser, S.T., Isern, J. and Baron, M.H. (2010) Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis. Methods in Enzymology, P. Wassarman and P. Soriano, eds. [invited chapter], vol. 476, pp. 403-427. PMID: 20691878.

Isern, J., Fraser, S.T., He, Z., Zhang, H., and Baron, M.H. (2010) Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood 116: 3972-3980. DOI 10.1182/blood-2010-04-281196. PMID:20720183. Cover article.

Isern, J., He, Z., Fraser, S.T., Nowotschin, S., Ferrer-Vaquer, A., Moore, R., Hadjantonakis, A.-K., Schulz, V., Tuck, D., Gallagher, P.G., and Baron, M.H. (2011) Single Lineage Transcriptome Analysis Reveals Key Regulatory Pathways in Primitive Erythroid Progenitors in the Mouse Embryo, Blood 117: 4924-4934, First Edition Paper, prepublished online January 24, 2011;DOI 10.1182/blood-2010-10-313676. PMID: 21263157. Cover article.
• This article was highlighted in the commentary Inside Blood, Mullner, E. Erythropoiesis: early, not primitive. Blood 117: 4685-4686.

Artus, J., Douvaras, P., Piliszek, A., Isern, J., Baron, M.H. and Hadjantonakis, A.-K. BMP4 signalling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity, Developmental Biology 361: 245-262. PMID: 22051107.

Baron, M.H., Isern, J. and Fraser, S. (2012) The embryonic origins of erythropoiesis in mammals. Blood 119: 4828-4837 [Invited review]. PMID: 22337720

Baron, M.H. (2013) Early Embryonic Erythropoiesis … Not so Primitive After All. Stem Cells 31: 849-856, doi: 10.1002/stem.1342. [Epub ahead of print] PMCID: PMC3637392 [Invited review].

Baron, M.H., Vacaru, A., and Nieves, J. (2013) Erythroid Development in the Mammalian Embryo. Blood Cells, Molecules and Diseases 51(4): 213-219, ed. J. Palis, [Invited review].

Vacaru, A., Isern, J., Fraser, S.T., and Baron, M.H. (2013) Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice. Genesis 51(11): 751-62. doi: 10.1002/dvg.22420. Epub 2013 Aug 30. [Epub ahead of print] PMID: 23913596. Cover article.

Zhang, H., Nieves, J.L., Fraser, S.T., Isern, J., Douvaras, P., Papatsenko, D., D’Souza, S., Lemischka, I.R., Dyer, M.A., and Baron, M.H. (2013) Expression of Podocalyxin separates the hematopoietic and vascular potentials of mouse ES cell-derived mesoderm. Stem Cells Cells 32(1): 191-203, DOI: 10.1002/stem.1536 [Epub ahead of print]

Baron, M.H. (2013) The TRIMming on an erythroid receptor complex. Blood 122: 3701-3702 [“Inside Blood,” invited commentary].

Pulina, M.V., Sahr, K.E., Baron, M.H.*, and Hadjantonakis, A.-K.* (2014) A conditional mutant allele for analysis of Mixl1 function in the mouse. Genesis 52: 417-423. * Joint corresponding authors. PMID: 24596343

Vacaru, A., Vitale, J., Nieves, J., and Baron, M.H. (2014) Generation of Transgenic Mouse Fluorescent Reporter Lines for Studying Hematopoietic Development. Methods Mol. Biol. 1194: 289-312, S.R. Singh, ed. (New York, Springer and Humana Press). DOI 10.1007/978-1-4939-1215-5_16 [Invited chapter].

Zhang, X., Camprecios, G., Rimmele, P., Liang, R., Yalcin, S., Mungamuri, S.K., Barminko, J., D’Escamard, V., Baron, M.H., Brugnara, C., Papatsenko, D., Rivella, S., and Ghaffari, S. (2014). FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis. Am J Hematol. 89(10): 954-963. Prepublished on 2014/06/27 as DOI 10.1002/ajh.23786 PMID:24966026

Fan, Y., Li, X., Fu, J., Harris, R., Lindenmeyer, M., Cohen, C.D., Guillot, N., Baron, M.H., Kyung, L., He, C., Schlondorff, D. and Chuang, P.Y. (2015) BAMBI elimination enhances non-canonical glomerular ERK1/2 and Smad1/5 signaling and glomerular dysfunction in diabetic mice. Diabetes 64: 2220-2233.  PMCID: PMC4439561.

Mercurio, S., S. Petrillo, D. Chiabrando, Z. I. Bassi, D. Gays, A. Camporeale, A. Vacaru, B. Miniscalco, G. Valperga, L. Silengo, F. Altruda, M. H. Baron, M. M. Santoro and E. Tolosano (2015). “The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.” Haematologica 100(6): 720-729.  PMCID: PMC4450617.

Lohmann, F., Dangeti, M.,  Soni, S., Chen, X., Planutis, A., Baron, M.H., Choi, K.C., and Bieker, J.J. (2015) The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Mol. Cell. Biol. 35: 3726-3738.  PMCID:  PMC4589598.

Barminko, J., Reinholt, B., and Baron, M.H.  (2016)  Development and differentiation of the erythroid lineage in mammals.  Developmental & Comparative Immunology 58: 18-29.  PMCID: PMC4775370.

Baron, M.H., and Barminko, J. (2016). Chromatin Condensation and Enucleation in Red Blood Cells:  an Open Question. Dev Cell 36:  481-482.

Barminko, J., Reinholt, B.M., Emmanuelli, A., Lejeune, A.N. and Baron, M.H.  (2018) Activation of the vitamin D receptor transcription factor stimulates the growth of definitive erythroid progenitors.  Blood Advances 2: 1207-1219.  PMCID: PMC599893.

Fu, J., Wei, C., Zhang, W., Schlondorff, D., Wu, J., Cai, M., He, W., Baron, M. H., Chuang, P. Y., Liu, Z., He, J. C., Lee, K. (2018) Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice. Kidney International 94(2): 326-345.  PMCID: PMC6054896.

Ebefors, K., Wiener, R.J., Yu, L., Azeloglu, E.U., Yi, Z., Jia, F., Zhang, W., Baron, M.H., He, J.C., Haraldsson, B., and Daehn, I. (2019) Endothelin receptor-A mediates degradation of glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells. Kidney International 96(4):957-970. PMCID: PMC7200072.

Barminko, J., Vacaru, A., and Baron, M.H. (2020) Generation of Transgenic Fluorescent Reporter Lines for Studying Hematopoietic Development in the Mouse. Methods in Molecular Biology, in press.

 

Margaret Baron Laboratory

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