Our lab is interested in molecular mechanisms of hematopoietic stem and progenitor cell fate specification and differentiation using mouse and human primary cellS, ES cell models, and mice. We have a longstanding interest in developmental hematopoiesis in mammals. One focus of the lab is to study signaling pathways in embryonic hematopoiesis and erythropoiesis (red blood cells) in the mouse. A second focus is on definitive (adult type) hematopoietic and erythroid progenitor development (mouse fetal liver or bone marrow, human progenitors from peripheral blood or bone marrow). We are developing a high throughput screen for regulators of erythroid progenitors as well as later stages of maturation, including enucleation, and are targeting specific ligand-activated transcription factor pathways for detailed analysis. Read more.
Margaret Baron Laboratory
Admin Phone: 212-241-6287
Icahn School of Medicine at Mount Sinai
1468 Madison Avenue, AB24-68
New York, NY 10029