In the Dar laboratory we interrogate questions that are related to links between conformational switching in cell signaling proteins and global effects on protein complex assembly. A guiding principal of the lab is that the fundamental structural and biochemical understanding of signal transduction networks within the context of cells and whole animals will allow us to better understand the benefits and limitations of targeted cancer therapeutics, and also to develop new strategies for drug discovery. Our work is highly interdisciplinary, employing methods from synthetic organic chemistry, X-ray crystallography, mass spectrometry, informatics, biochemistry and model organism genetics. Please read on to learn more about the lab.