Publications

Disability innovation strengthens STEM. Daehn IS, Croxson PL. Science. 2021 Sep 3;373(6559):1097-1099.

Clues to Glomerular Cell Chatter in Focal Segmental Glomerulosclerosis: Via Endothelin-1/ET A R. Lassén E, Daehn IS. Kidney Int Rep. 2021 May 20;6(7):1758-1760.

The glomerular filtration barrier: a structural target for novel kidney therapies. Daehn IS, Duffield JS. Nat Rev Drug Discov. 2021 Jul 14:1-19. doi: 10.1038/s41573-021-00242-0.

Modeling the Glomerular Filtration Barrier and Intercellular Crosstalk. Ebefors K, Lassén E, Anandakrishnan N, Azeloglu EU, Daehn IS. Front Physiol. 2021 Jun 2;12:689083.

Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction, Lassén E, Daehn IS. Int J Mol Sci. 2020 Dec 11;21(24):9456.

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes  Casalena GA, Yu L, Gil R, Rodriguez S, Sosa S, Janssen W, Azeloglu EU, Leventhal JS, Daehn IS. Cell Commun Signal. 2020 Jul 8;18(1):105.

Mitochondria Matter: A Critical Role of ADCK4 in Stabilizing the CoQ Complex in Podocytes in Steroid-Resistant Nephrotic Syndrome  Daehn IS. J Am Soc Nephrol. 2020 Jun;31(6):1167-1169.

Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells. Ebefors K, Wiener RJ, Yu L, Azeloglu EU, Yi Z, Jia F, Zhang W, Baron MH, He JC, Haraldsson B, Daehn I.  Kidney Int. 2019 Oct;96(4):957-970.

Biological Variability of Estimated GFR and Albuminuria in CKD. Waikar SS, Rebholz CM, Zheng Z, Hurwitz S, Hsu CY, Feldman HI, Xie D, Liu KD, Mifflin TE, Eckfeldt JH, Kimmel PL, Vasan RS, Bonventre JV, Inker LA, Coresh J; Chronic Kidney Disease Biomarkers Consortium Investigators.  Am J Kidney Dis. 2018 Jul 18.

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney DiseaseDaehn IS. Front Med (Lausanne). 2018 Apr 26;5:113.

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases. Atreya I, Diall A, Dvorsky R, Atreya R, Henninger C, Grün M, Hofmann U, Schaeffeler E, López-Posadas R, Daehn I, Zenker S, Döbrönti M, Neufert C, Billmeier U, Zundler S, Fritz G, Schwab M, Neurath MF. J Crohns Colitis. J Crohns Colitis. 2016 Oct;10(10):1132-43.

Shift in Focus-To Explore the Role of the Endothelium in Kidney Disease. Daehn I. HSOA J Nephrol Ren Ther. 2016;2(1):004.

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion. Kaverina NV, Eng DG, Largent AD, Daehn I, Chang A, Gross KW, Pippin JW, Hohenstein P, Shankland SJ. Stem Cell Reports. 2017 Oct 10;9(4):1152-1166.

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility. Qi H, Casalena G, Shi S, Yu L, Ebefors K, Sun Y, Zhang W, D’Agati V, Schlondorff D, Haraldsson B, Böttinger E, Daehn I. Diabetes. 2017 Mar;66(3):763-778.

Dendrin ablation prolongs life span by delaying kidney failure. Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN. Am J Pathol. 2015 Aug;185(8):2143-57

Commentary http://www.sciencedirect.com/science/article/pii/S0002944015002795

Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG; CKD Biomarkers Consortium. (2015)  Clin J Am Soc Nephrol. May 7;10(5):894-902.

Krüppel-like factor 6 regulates mitochondrial function in the kidney. Mallipattu SK, Horne SJ, D’Agati V, Narla G, Liu R, Frohman MA, Dickman K, Chen EY, Ma’ayan A, Bialkowska AB, Ghaleb AM, Nandan MO, Jain MK, Daehn I, Chuang PY, Yang VW, He JC. (2015). J Clin Invest. Mar 2;125(3):1347-61.

EDITORIAL http://www.jci.org/articles/view/80280/version/1/pdf/render

Microvascular endothelial cells poised to take center stage in experimental renal fibrosis. Daehn I, Bottinger EP (2014). J Am Soc Nephrol – Editorial. Apr;26(4):767-9. Epub 2014 Dec 22.
Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. Daehn I, Casalena G, Zhang T, Shi S, Fenninger F, Barasch N, Yu L, D’Agati V, Schlondorff D, Kriz W, Haraldsson B, Bottinger EP. J Clin Invest. 2014 Apr;124(4):1608-21.

Press release: http://www.sciencedaily.com/releases/2014/03/140303153928.htm

http://www.eurekalert.org/pub_releases/2014-03/tmsh-mss022714.php#.UxXpZGa0YQw

Casalena G, Krick S, Daehn I, Yu L, Ju W, Shi S, Tsai S, D’Agati V, Lindenmeyer M, Cohen CD, Schlondorff D, Bottinger EP. (2014) Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro. Am. J. Physiol. Renal Physiol. Jun 1;306(11):F1372-80.

Ilse Daehn, and Eleanor Wendell. “Big Apple Covets Big Biotech Presence.” (2013). GEN Dec 1, Vol. 33 (21) .

Foster MC, Inker LA, Levey AS, Selvin E, Eckfeldt J, Juraschek SP, Coresh J; CKD Biomarkers Consortium. (2013) Novel filtration markers as predictors of all-cause and cardiovascular mortality in US adults. Am J Kidney Dis. Jul;62(1):42-51.

Gentle ME, Shi S, Daehn I, Zhang T, Qi H, Yu L, D’Agati VD, Schlondorff DO, Bottinger EP. (2013) Epithelial Cell TGFβ Signaling Induces Acute Tubular Injury and Interstitial Inflammation. J Am Soc Nephrol. 24(5):787-99.

Casalena G, Daehn I, Bottinger EP. (2012) Transforming Growth Factor Beta, Bioenergetics and Mitochondria in Renal Disease. Seminars Nephrol. 32(3):295-303.

Daehn I, Brem R, Karran P. (2011). Accumulated oxidative DNA damage in mitochondria of thiopurine-treated cells. FEBS Lett. 585(24):3941-6.

Brem R, Daehn I, Karran P. (2011). Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation. DNA Repair (Amst). 10(8):869-76.

Daehn I, Varelias A, Rayner TE. (2010). T-lymphocyte-induced, Fas mediated apoptosis targets early keratinocyte differentiation. Exp Dermatol. 19(4):372-80.

Daehn I, Karran P (2009). Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 69(6):2393.

Daehn IS, Varelias A, Rayner TE. (2006). Sodium butyrate induced keratinocyte apoptosis. Apoptosis. 11(8):1379-90.

Ruzehaji G, Daehna I, Vareliasa A & Rayner T. (2006). Exploring cellular interactions relevant to wound healing. Primary Intention. 14:22-30.

Gangnuss S, Cowin AJ, Daehn IS, Hatzirodos N, Rothnagel JA, Varelias A, Rayner TE. (2004). Regulation of MAPK activation, AP-1 transcription factor expression and keratinocyte differentiation in wounded fetal skin. J Invest Dermatol. 122(3):791-804.

Blanco-Colio LM, Justo P, Daehn I, Lorz C, Ortiz A, Egido J. (2003). Bcl-xL overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells. Kidney Int. 64(1):181-91.