2021
Cao, C.; Kang, H. J.; Singh, I.; Chen, H.; Zhang, C.; Ye, W.; Hayes, B. W.; Liu, J.; Gumpper, R. H.; Bender, B. J.; Slocum, S. T.; Krumm, B. E.; Lansu, K.; McCorvy, J. D.; Kroeze, W. K.; English, J. G.; DiBerto, J. F.; Olsen, R. H. J.; Huang, X. P.; Zhang, S.; Liu, Y.; Kim, K.; Karpiak, J.; Jan, L. Y.; Abraham, S. N.; Jin, J.; Shoichet, B. K.; Fay, J. F.; Roth, B. L., Structure, function and pharmacology of human itch GPCRs. Nature 2021, 600, 170-175. PMID: 34789874.
Yu, X.; Li, D.; Kottur, J.; Shen, Y.; Kim, H. S.; Park, K. S.; et al, Kaniskan, H. Ü.; Cai, L.; Jain, R.; Liu, J.; Aggarwal, A. K.; Wang, G. G.*; Jin, J.* A Selective WDR5 Degrader Inhibits Acute Myeloid Leukemia in Patient-Derived Mouse Models. Science Translational Medicine 2021, 13, eabj1578. PMID:34586829.
Wei, J.; Meng, F.;Park, K.; Yim, H.; Velez, J.; Kumar, P.; Wang, L.; Xie, L.; Chen, H.; Shen, Y.; Teichman, E.; Wang, G.; Chen, X.; Kaniskan, H.*; Jin, J.* Harnessing the E3 ligase KEAP1 for targeted protein degradation. J. Am. Chem. Soc. 2021, 143, 37, 15073–15083. PMID: 34520194，PMCID:PMC8480205.
Xu, J.; Yu, X.; Martin, T. C.; Bansal, A.; Cheung, K.; Lubin, A.; Stratikopoulos, E.; Cahuzac, K. M.; Wang, L.; Xie, L.; Zhou, R.; Shen, Y.; Wu, X.; Yao, S.; Qiao, R.; Poulikakos, P. I.; Chen, X.; Liu, J.; Jin, J.*; Parsons, R.* AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild-type KRAS and BRAF by destabilizing Aurora kinase B. Cancer Discovery 2021, 11, 3064-3089. PMID: 34301793.
Lu, S. X.; De Neef, E.; Thomas, J. D.; Sabio, E.; Rousseau, B.; Gigoux, M.; Knorr, D. A.; Greenbaum, B.; Elhanati, Y.; Hogg, S. J.; Chow, A.; Ghosh, A.; Xie, A.; Zamarin, D.; Cui, D.; Erickson, C.; Singer, M.; Cho, H.; Wang, E.; Lu, B.; Durham, B. H.; Shah, H.; Chowell, D.; Gabel, A. M.; Shen, Y.; Liu, J.; Jin, J.; Rhodes, M. C.; Taylor, R. E.; Molina, H.; Wolchok, J. D.; Merghoub, T.; Diaz, L. A.; Abdel-Wahab, O.*; Bradley, R. K.* Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell, 2021, 184, 4032-4047. PMID: 34171309
Dale, B.; Cheng, M.; Park, K.-S.; Kaniskan, H. Ü.; Xiong, Y.*; Jin, J*. Advancing targeted protein degradation for cancer therapy. Nature Reviews Cancer2021, 21, 638-654. PMID: 34131295, PMCID: PMC8463487.
Li, J.; Galbo, P. M., Jr.; Gong, W.; Storey, A. J.; Tsai, Y. H.; Yu, X.; Ahn, J. H.;Guo, Y.; Mackintosh, S. G.; Edmondson, R. D.; Byrum, S. D.; Farrar, J. E.; He, S.; Cai, L.; Jin, J.; Tackett, A. J.; Zheng, D.; Wang, G. G.* ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nat. Commun. 2021, 12, 1045. PMID: 33594072, PMCID: PMC7886901.
Wu, X.; Yang, X.; Xiong, Y.; Li, R.; Ito, T.; Ahmed, T. A.; Karoulia, Z.; Adamopoulos, C.; Wang, H.; Wang, L.; Xie, L.; Liu, J.; Ueberheide, B.; Aaronson, S. A.; Chen, X.; Buchanan, S. G.; Sellers, W.R.; Jin, J.; Poulikakos, P. I.* Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nature Cancer 2021, 2, 429-443.
Bhat, K. P.; Ümit Kaniskan, H.; Jin, J.*; Gozani, O.* Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat. Rev. Drug Discov. 2021, 20, 265-286. PMID: 33469207, PMCID: PMC8035146.
Xu, J.; Yu, X.; Martin, T. C.; Bansal, A.; Cheung, K.; Lubin, A.; Stratikopoulos, E.; Cahuzac, K. M.; Wang, L.; Xie, L.; Zhou, R.; Shen, Y.; Wu, X.; Yao, S.; Qiao, R.; Poulikakos, P. I.; Chen, X.; Liu, J., Jin, J.*; Parsons, R.* AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway Mutant Cancers with Wild Type KRAS and BRAF by Destabilizing Aurora Kinase B, Cancer Discovery , 2021, 11, 3064-3089.
PMID: 34301793 PMCID: PMC9056008.