Recent Publications

  • Cai B*, Wang X. Liver cholesterol matters. Aging (Albany NY). 2020, 12(20):19828-19829. *corresponding author
  • Cai B*, Kasikara C. TAM receptors and their ligand-mediated activation: Role in atherosclerosis. Int Rev Cell Mol Biol. 2020, 357:21-33. *corresponding author
  • Wang X, Cai B. MerTK, a risk factor for NASH fibrosis. Aging (Albany NY).2020, 12(20):19832-19833.
  • Cai B*, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I*. Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis. Cell Metab, 2019, 31(2):406-421. *corresponding authors. (Comment in: Wen Y, Ju C, MER proto-pncogene tyrosine kinase: A novel potential target to treat nonalcoholic steatohepatitis fibrosis, Hepatology, 08/2020)
  • Cai B*, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I*. MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal, 2018, 11(549). *corresponding authors. Recommended to F1000Prime.
  • Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I. MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J Clin Invest, 2017, 127(2):564-568.
  • Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci USA, 2016, 113(23):6526-31.
  • Wang X, Cai B, Yang X, Zheng Z, Valenti L, Pajvani UB, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. Cholesterol activates a TAZ-Stabilization pathway in hepatocytes to promote nonalcoholic steatohepatitis. Cell Metab, 2020, 31(5):969-986.
  • Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Blood, 2018, 133(7):743-753.
  • Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. Macrophage inflammation, erythrophagocytosis, and accelerated atherosclerosis in Jak2V617F mice. Circ Res, 2018, 123(11):e35-e47.
  • Doran AC*, Ozcan L*, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J Clin Invest, 2017, 127(11):4075-4089. *equal contributors.
  • Wang Y*, Subramanian M*, Yurdagul A Jr*, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR, Tabas I. Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages. Cell, 2017, 171(2):331-345. *equal contributors.
  • Wang X, Zheng Z, Caviglia JM, Corey KE, Herfel TM, Cai B, Masia R, Chung RT, Lefkowitch JH, Schwabe RF, Tabas I. Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis. Cell Metab, 2016, 24(6):848-862.
  • Cai B, Xie S, Liu F, Simone L, Caplan S, Qin X, Naslavsky, N. Rapid degradation of the complement regulator, CD59, by a novel inhibitor. J Biol Chem, 2014, 289(17):12109-25.
  • Cai B*, Xie S*, Caplan S, Naslavsky, N. GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation. Front. Cell Dev Biol, 2014, 2:22. *equal contributors.
  • Cai B*, Giridharan SS*, Zhang J*, Saxena S, Bahl K, Schmidt J, Sorgen, P, Guo W, Naslavsky, N, Caplan S. Differential roles of C-terminal Eps15 Homology Domain proteins as vesiculators and tubulators of recycling endosomes. J Biol Chem, 2013, 288(42):30172-80. *equal contributors.
  • Cai B, Caplan S, Naslavsky N. cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes. Mol Biol Cell, 2012, 23 (10):1874-88.
  • Cai B, Katafiasz D, Horejsi V, Naslavsky N. Pre-sorting endosomal transport of the GPI-anchored protein, CD59, is regulated by EHD1. Traffic, 2011, 12 (1):102-20.

complete list: https://www.ncbi.nlm.nih.gov/myncbi/1biTw-m3sr35_/bibliography/public/