Welcome to the Bishuang Cai Laboratory

​Inflammation resolution is mediated by specialized pro-resolving mediators (SPMs) such as lipoxins, resolvins, protectins, and maresins. These resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, serving to limit tissue damage and to enable tissue repair. However, inflammation resolution becomes defective in NASH and atherosclerosis. We aim to elucidate the mechanisms of dysregulated SPM biosynthesis in macrophage and its consequences to NASH/atherosclerosis and identify unique pathways that hold promise for future therapies. The laboratory applies technologies such as transgenic mouse models, human genetics, single-cell RNA sequencing, and a variety of cell and molecular techniques.

We are currently seeking enthusiastic postdoctoral researchers, graduate students, and technicians to join our team. Highly motivated individuals with interests in the roles of macrophage in NASH and atherosclerosis are encouraged to apply. Feel free to contact us at bishuang.cai@mssm.edu.