Our Team
Jeffrey Newcorn – Psychiatry | Mount Sinai – New York
Professor Department of Psychiatry, Medical Director Division of ADHD, Learning Disabilities, and Related Disorders
Director, Center for Excellence in ADHD and Related Disorders
Director, ADHD Clinical and Translational Studies Program Director,
Pediatric Psychopharmacology at the Mount Sinai Health System
orcid.org Profile • scopus.com Profile • Dr. Newcorn’s CV
Email: Jeffrey.Newcorn@mssm.edu
Call: 212-659-8775
Iliyan Ivanov – Psychiatry | Mount Sinai – New York
Associate Professor Department of Psychiatry
Medical Director CARES Program
Medical Director FuTuReS Program
orcid.org Profile • scopus.com Profile • Dr. Ivanov’s CV
Email: Iliyan.Ivanov@mssm.edu Call: 212-523-3153
Beth Krone | Mount Sinai – New York
Assistant Professor Psychiatry
Research Manager, Center of Excellence for ADHD and Related Disorders
Research Manager, Tourette’s Association of America Center for Excellence
NYS Licensed Clinical Psychologist
orcid.org Profile • scopus.com Profile • Dr. Krone’s CV
Email: Beth.Krone@mssm.edu Call: 212-241-8012 or 646-535-1618
Kurt Schulz | Mount Sinai – New York
Assistant Professor Psychiatry
Neuroscientist
Research Profile • Dr. Schulz’s CV
Email: Kurt.Schulz@mssm.edu
Some of our Current Research Partners:
Dr. Lenard Adler, NYU Langone Health
Dr. John Markowitz, University of Florida
Dr. Haojie Zhu, University of Michigan
Dr. Mark Stein, University of Washington Seattle Children’s Hospital
Dr. Tanya Froehlich, Cincinnati Children’s Hospital
Dr. James Blair, University of Copenhagen
Dr. Iris Manor, Geha Mental Health Center
Dr. Mark Owens, The League School
The ADHD Clinical and Translational Studies Program
The ADHD Clinical and Translational Studies Program is uniquely situated at the heart of one of the world’s premier academic medical centers. Our international collaborations with world-class clinicians and scientists has produced (and keeps producing) critical insights into the development, presentation, consequences, and treatment of ADHD and related disorders throughout the lifespan.
As part of the Division of ADHD, Learning Disabilities, and Related Disorders at the Icahn School of Medicine at Mount Sinai, our scientists are highly regarded educators and clinicians who provide learning experiences for trainees while producing the scientific evidence that informs our senior colleagues’ practice and research in the field. Our program contributes to the high ranking of our Psychiatry Department, as the #6 recipient of NIH funding for research in the United States.
As an integral part of the Center for Excellence for ADHD and Related Disorders at the Mount Sinai Health System, we take our commitment to patient care very seriously. This means that our patients receive top quality and cutting-edge care.
Professor, Department of Psychiatry
Medical Director, Division of ADHD, Learning Disabilities, and Related Disorders
Director, Center for Excellence in ADHD and Related Disorders
Director, ADHD Clinical and Translational Studies Program
Director, Pediatric Psychopharmacology at the Mount Sinai Health System
Contact Us
Phone: 646-535-1618
Current Projects
We currently hold three NIH funded grants researching ADHD among youth, employing cutting edge neuroimaging, pharmacogenetics, and genomics in human translational research:
We are conducting two R21 pilot studies (NCT03781765) to determine if there are differing neurobiological effects in the brain’s reward system between a group of youth with ADHD and a group of youth with ADHD+ Conduct Disorder (CD) OR ADHD + severe Oppositional Defiant Disorder (ODD), and whether these differences are magnified or reduced when treated with commonly prescribed, FDA approved stimulant or non-stimulant medications. For these studies, previously untreated youths ages 8 to 12 years old are evaluated and treated by our team of expert clinicians. Our neuroscience team will capture baseline and post treatment functional magnetic resonance images while children play videogame-based neuropsychological tasks that capture medication mediated change. These studies will serve as a basis for larger grants exploring the effects of these medications
We are the clincial coordinating center for a nation-wide study (NCT03781752) to determine the impact of carboxylesterase (CES1) gene variants on metabolism of the most commonly prescribed, FDA approved stimulant medication for treatment for ADHD. CES1 genes are responsible for producing the enzymes that breakdown several classes of drugs, including methylphenidates (MPH), in the liver. For this study, our treatment teams will monitor treatment of youth ages 6 to 17 years old in clinical practice. Youth with genotypes of interest will be asked to complete a pharmacokinetic procedure to assess group differences in MPH metabolism. Results of this study will inform personalized treatments and application of precision medicine in clinical decision making, with the goal of reducing the time between diagnosis and finding effective treatment, and reducing side effect risks.
Our most recent industry sponsored clinical studies are focused on a number of areas:
We are treating adults ages 18 to 55 years with ADHD using a new, non-stimulant drug called Centanafadine (NCT03605849) to determine whether it is effective and safe for treating ADHD
We currently are conducting two studies of Molindone (NCT02691182). Our doctors are treating youth ages 6 to 12 years old, who are receiving an FDA approved medication for ADHD according to best clinical practice guidelines, but who continue to experience impairing outbursts of impulsive aggression, in concert with their own prescribing physicians to optimize care. This study seeks to determine the efficacy of Molindone for aggression among youth with ADHD.
Recent Publications
Nomura, Y., Newcorn, J. H., Ginalis, C., Heitz, C., Zaki, J., Khan, F., Nasrin, M., Sie, K., DeIngeniis, D., & Hurd, Y. L. (2022). Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study. Journal of child psychology and psychiatry, and allied disciplines, 10.1111/jcpp.13698. https://pubmed.ncbi.nlm.nih.gov/36129196/
Merzon, E., Weiss, M., Krone, B., Cohen, S., Ilani, G., Vinker, S., Cohen-Golan, A., Green, I., Israel, A., Schneider, T., Ashkenazi, S., Weizman, A., & Manor, I. (2022). Clinical and Socio-Demographic Variables Associated with the Diagnosis of Long COVID Syndrome in Youth: A Population-Based Study. International journal of environmental research and public health, 19(10), 5993. https://doi.org/10.3390/ijerph19105993. https://pubmed.ncbi.nlm.nih.gov/35627530/
Michael J. Silverstein, BA; Terry L. Leon, MS, RN; Beth Krone, PhD; Stephen V. Faraone, PhD; Jeffrey H. Newcorn, MD; Lenard A. Adler, MD (2019). The Characteristics and Unique Impairments of Comorbid Adult ADHD and Sluggish Cognitive Tempo: An Interim Analysis. Psychiatric Annals. 2019;49(10):457-465. https://doi.org/10.3928/00485713-20190905-01
Connor DF, Newcorn JH, Saylor KE, Amann BH, Scahill L, Robb AS, Jensen PS, Vitiello B, Findling RL, Buitelaar JK. Maladaptive Aggression: With a Focus on Impulsive Aggression in Children and Adolescents. J Child Adolesc Psychopharmacol. 2019 Oct;29(8):576-591. doi: 10.1089/cap.2019.0039. Epub 2019 Aug 27. Free PMC Article
Ivanov I, Schulz K, Li X, Newcorn J. Reward Processing in Drug-Naive Youth with Various Levels of Risk for Substance Use Disorders: A Pilot Study. J Child Adolesc Psychopharmacol. 2019 Aug;29(7):516-525. doi: 10.1089/cap.2018.0175. Epub 2019 Jun 10. PMID:31180232
Schulz, KP, Bédard, A-CV, Fan, J, Hildebrandt, TB, Stein, MA, Ivanov, I, Halperin, JM, Newcorn, JH. (2017). Striatal Activation Predicts Differential Therapeutic Responses to Methylphenidate and Atomoxetine. J Am Acad Child Adolesc Psychiatry. Jul;56(7):602-609.e2. doi: 10.1016/j.jaac.2017.04.005. Epub 2017 May 10. PMID: 28647012
Faraone SV, Rostain AL, Montano CB, Mason O, Antshel KM, Newcorn JH. Systematic Review: Nonmedical Use of Prescription Stimulants: Risk Factors, Outcomes, and Risk Reduction Strategies. J Am Acad Child Adolesc Psychiatry. 2019 Jul 18. pii: S0890-8567(19)30470-8. doi: 10.1016/j.jaac.2019.06.012. [Epub ahead of print] Review. Free Article
Newcorn, JH., Krone, B., Hildebrandt, T, & Stein, M. (2017). Methylphenidate vs. Atomoxetine in Youth with ADHD: Comparative Effectiveness and Preference following Treatment with both Medications. Biological Psychiatry. DOI: 10.1016/j.biopsych.2017.02.581
Faraone, S, Rostain, AL, Blader, J, Busch, B, Childress, A, Connor, D, Newcorn, JH. (2018). Practitioner Review: Emotional Dysregulation in ADHD – Implications for Clinical Recognition and Intervention. J Child Psychol Psychiatry Apr 6. doi: 10.1111/jcpp.12899. [Epub ahead of print] Review. PMID: 29624671
Selected Textbooks
Krone, B, Ivanov, I & Newcorn, J. (2019). Aggression in Disruptive Behavior Disorders. In Coccaro & McCloskey (Eds) Aggression: Clinical Features and Treatment Across the Diagnostic Spectrum. American Psychiatric Association
Krone, B & Newcorn, J. ADHD (2019). In: Alosco & Stern (Eds.) The Oxford Handbook of Adult Cognitive Disorders. Oxford University Press
Krone, B & Newcorn, JH (2015). Comorbidity of ADHD and Anxiety Disorders: Descriptive and Clinical Features, Diagnosis and Treatment Across the Lifespan. In: Adler, Wilens, Spencer (Eds.) Attention-Deficit Hyperactivity Disorder in Adults and Children. Cambridge University Press
Newcorn, JH, Leikauf, J, Johnson, B, Krone, B, Halperin, JM (2015). Attention-deficit/Hyperactivity Disorder. In: A. Tasman, J. Kay, J.A. Lieberman (Eds.) Psychiatry, 4th edition. W.B. Saunders: Philadelphia
Dr. Lenard Adler, M.D. is a long-time collaborator, colleague, and friend to our lab. Our most recent joint works included a study of the cognitive and neurocognitive correlates of Sluggish Cognitive Tempo (SCT) among adults with ADHD.
Dr. James Blair, Ph.D. is a world renowned expert on the neurobiology of aggression. He has most recently collaborated with us on neuroimaging studies of the emotional biasing of cognition and amygdala activation among adults with ADHD, and his team is currently consulting on our NIH funded pilot studies of the neurobiological predictors of substance abuse among youth with aggression.
Dr. John Markowitz, Pharm.D. is another long-time collaborator, colleague, and friend who is the current Principal Investigator of our translational R01 study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development
Dr. Tanya Froehlich, M.D. is a pediatrician who has been conducting molecular research in ADHD. She is a clinical collaborator on our current R01 examining genetic markers of methylphenidate metabolism.
Dr. Haojie Zhu, Ph.D. studies Pharmacogenomics, Pharmacokinetics, and Neuropsychopharmacology, focusing on identifying both genetic variations and environmental factors that impact pharmacokinetics and pharmacodynamics of various therapeutic agents. he is a collaborator on our multi-state R01 examining methylphenidate metabolism.
Dr. Mark Stein, Ph.D. is has been a collaborator, colleague, and friend who has worked closely with our team on large-scale, NIH funded clinical trials of ADHD in youth. He is currently a collaborator on our multi-site pharmacogenetics study of CES metabolism and ADHD.
Dr. Jin Fan, Ph.D. ia a world renowned cognitive neuroscientist who has guided our neuroimaging work for decades. Dr. Fan is continues to mentor Dr. Schulz’s work on response inhibition, and executive control in ADHD
Clinical Practice
The Clinical and Translational studies program is part of the Center for Excellence for ADHD and Related Disorders at the Mount Sinai Health System and the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai. Our doctors work in the clinical programs and practices at Mount Sinai.
For more information about Dr. Newcorn’s Clinical Faculty Practice, please call his clinical practice coordinator at 212-659-8705.
To learn more about our clinical behavioral program for children, adolescents, adults, and parents with ADHD, visit https://icahn.mssm.edu/research/adhd
Related links
ADHD in Adults
http://ADHDinAdults.com
Canadian ADHD Resource Alliance
https://www.caddra.ca/
US National Library of Medicine Clinical Trails Registry
American Professional Society for ADHD and Related Disorders
https://apsard.org
ADHD World Federation
http://www.adhd-federation.org/