The Mehandru Lab serves as a nidus of patient-centered, cutting-edge work in human mucosal immunology at the Icahn School of Medicine at Mount Sinai. Our goal is to better understand the human mucosal immune system in health and in individuals with mucosal inflammation (inflammatory bowel diseases), HIV and primary immunodeficiencies, and SARS-CoV-2 and viral disorders of the intestinal tract.

While our laboratory’s work emphasizes state-of-the-art technologies for patient-centered studies, we also employ animal models as appropriate, in order to develop mechanistic insights into human mucosal diseases. Additionally, we collaborate closely with investigators in the field of microbiome research as well as other immune mediated inflammatory disorders (IMIDs). Finally, we are committed to training the next generation of high-quality investigators in the field of mucosal immunology.

The lab proudly hosts a team of highly collaborative and talented individuals as detailed here.

Broad aspects of our laboratory’s work and interests are reflected in the list of our recent publications.