Publications


ISI Web of Knowledge Summary (09/08/17)

  • Results found: 107
  • Sum of times cited: 3410
  • Average citations per item: 31.87
  • H-index: 29

2019

Strauss B, Sassi Y, Bueno-Beti C…..Akar FG. Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension. J Mol Cell Cardiol. 2019; 127:20-30. PMID: 30502350. 

 

2018

Ilkan Z, Akar FG. The Mitochondrial Translocator Protein and the Emerging Link between Oxidative Stress and Arrhythmias in the Diabetic Heart. Front Physiol. 26 Oct 2018. https://doi.org/10.3389/fphys.2018.01518

Motloch LJ, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. Primary Effect of SERCA2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction. J Am Heart Assoc. 2018. Sep 18; 7(18): doi/10.1161/JAHA.118.009598

Ishikawa K, Watanabke S, Lee P, Akar FG, Fish K, Kho C, Hajjar RJ (2018). Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias. J Am Coll Cardiol. 2018; 72(7): 738-750.

Ilkan Z, Strauss B, Campana C, Akar FG (2018). Optical Action Potential Mapping in Acute Models of Ischemia-Reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein. Methods Mol Biol. 2018; 1816:133-143. doi: 10.1007/978-1-4939-8597-5_10. PMID: 29987816.

Strauss B, Akar FG (2018). Kir2.1 and Nav1.5 in sickness and in health: who needs a chaperone when they have an alpha partner? Circ Res. April 25, 2018. PMID: 29798894.

 

2017

Campana C, Akar FG (2017). Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics. 2017; 6(5):59. doi: 10.3389/fbioe.2017.00059. PMID: 29057224.

Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG (2017). Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc Diabetol. 2017; 16(1):120. doi: 10.1186/s12933-017-0604-9. PMID: 28962617.

Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias EG, Weber T, Akar FG, Hajjar RJ (2017). Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonichemic Heart Failure. J Am Coll Cardiol. 2017; 70(14): 1744-1756. PMID: 28958332.

Motloch LJ, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG (2017). Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia. JACC Basic Transl Sci. 2017; 2(3):258-269. doi: 10.1016/j.jacbts.2017.02.002. PMID: 28798965

2016

Nederlof R, Gürel-Gurevin E, Eerbeek O, Xie C, Deijs GS, Konkel M, Hu J, Weber NC, Schumacher CA, Baartscheer A, Mik EG, Hollmann MW, Akar FG, Zuurbier CJ (2016). Reducing mitochondrial bound hexokinase II mediates transition from non-injurious to injurious ischemia-reperfusion of the intact heart. J Physiol Biochem. 2016; doi: 10.1007/s13105-017-0555-3. PMID: 28258543

Akar FG (2016). Starve a fever to heal a heart? Interleukin 18 gives new meaning to an old adage. Am J Physiol Heart Circ Physiol. In Press. PMID: 27342879

 2015

Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH (2015). LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015; 108(1): 197-208. PMID: 26378152

Xie C, Hu J, Motloch LJ, Karam BS, Akar FG (2015). The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. J Am Coll Cardiol. 2015; 66(10): 1144-56. PMID: 26337994 Motloch LJ, Jun Hu, Akar FG (2015). The Mitochondrial Translocator Protein and Arrhythmogenesis in Ischemic Heart Failure. Oxid Med Cell Longev. 205; 2015: 234104.PMID: 25918579

Motloch LJ, Akar FG (2015). Gene therapy to restore electrophysiological function in heart failure. Expert Opin Biol Ther. 2015 Apr 12: 1-15. PMID: 25865107

2014

Karam BS, Akar FG (2014). Blue LEDs get the Nobel Prize while Red LEDs are poised to save lives. Front Physiol. 2014; 5:443. eCollection 2014. PMID: 25452731; PMCID: PMC4231988.

Xie C, Kauffman J, Akar FG (2014). Functional crosstalk between the mitochondrial PTP and KATP channels determine arrhythmic vulnerability to oxidative stress. Front Physiol. 2014; 5:264. doi: 10.3389/fphys.2014.00264. eCollection 2014. PMID: 25076913; PMCID: PMC4099963.

Akar FG (2014). A formidable “TASK”: tipping the balance in favor of rhythm control for the management of atrial fibrillation. Heart Rhythm. 2014 Oct; 11(10):1806-7. PubMed PMID: 25041966.

Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG … Kranias EG, Hajjar RJ. Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure. Mol Ther. 2014;22(12):2038-45. PubMed PMID: 25023328.

Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure. Gene Ther. 2014; 21(4):379-86. PMID: 24572786; PubMed Central PMCID: PMC3976435.

Akar FG, Hajjar RJ (2014). Gene therapies for arrhythmias in heart failure. Pflugers Arch. 2014; 466(6):1211-7. PubMed PMID: 24566976; PubMed Central PMCID: PMC4070506.

Akar FG (2014). Emergence of atrial repolarization alternans at late stages ofremodeling: the “second factor” in atrial fibrillation progression? J Cardiovasc Electrophysiol. 2014; 25(4):428-30. PubMed PMID: 24479610.

Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G,Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB J. 2014; 28(2):644-54. PubMed PMID: 24174427; PubMed Central PMCID: PMC3898643.

2013

Akar FG (2013). Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention? J Interv Card Electrophysiol. 2013; 37(3):249-58. PubMed PMID: 23824789.

Xie C, Biary N, Tocchetti CG, Aon MA, Paolocci N, Kauffman J, Akar FG (2013). Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs. Am J Physiol Heart Circ Physiol. 2013; 304(7):H916-26. PMID: 23376824; PubMed Central PMCID: PMC3625895.

Nederlof R, Xie C, Eerbeek O, Koeman A, Milstein DM, Hollmann MW, Mik EG,Warley A, Southworth R, Akar FG, Zuurbier CJ (2013). Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia. Circ Res. 2013; 112 (2):e8-13. PubMed PMID: 23329797; PubMed Central PMCID: PMC3596767.  

2012

Karam CS, Akar FG (2012). Genetic silencing of pacemaker cells: local intervention with global implications. J Am Heart Assoc. 2012; 1(2):e001412. doi:10.1161/JAHA.112.001412. PubMed PMID: 23130130; PubMed Central PMCID: PMC3487369.

Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O’Rourke B,Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA (2012). GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes. 2012; 61(12):3094-105. PubMed PMID: 22807033; PubMed Central PMCID: PMC3501888.

2011

Biary N, Xie C, Kauffman J, Akar FG (2011). Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intactmyocardium. J Physiol. 2011; 589(Pt 21):5167-79. PubMed PMID: 21825030; PubMed Central PMCID: PMC3225672.

Salama G, Akar FG (2011). Deciphering Arrhythmia Mechanisms – Tools of the Trade. Card Electrophysiol Clin. 2011; 3(1):11-21. PubMed PMID: 21572551; PubMed Central PMCID: PMC3093299.

Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, vanHorssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M,Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ (2011). Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis. Circ Res. 2011; 108(10):1165-9. PubMed PMID: 21527739.

Akar FG, O’Rourke B (2011). Mitochondria are sources of metabolic sink andarrhythmias. Pharmacol Ther. 2011;131(3):287-94. PubMed PMID:21513732; PubMed Central PMCID: PMC3138548.

2010

Hajjar RJ, Akar FG (2010). Regression of cardiac hypertrophy by cyclic guanosinemonophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries? J Am Coll Cardiol. 2010 Dec 7; 56(24):2031-2. PubMed PMID: 20970281.

Biary N, Akar FG (2010). A brighter side of ROS revealed by selective activation of beta-adrenergic receptor subtypes. J Physiol. 2010; 588 (Pt 16):2973-4. PubMed PMID: 20710039; PubMed Central PMCID: PMC2956937.

Lyon AR, Joudrey PJ, Jin D, Nass RD, Aon MA, O’Rourke B, Akar FG (2010). Optical imaging of mitochondrial function uncovers actively propagating waves ofmitochondrial membrane potential collapse across intact heart. J Mol CellCardiol. 2010; 49 (4):565-75. PubMed PMID: 20624394; PubMed Central PMCID: PMC3081287.

Kong CW, Akar FG, Li RA (2010). Translational potential of human embryonic andinduced pluripotent stem cells for myocardial repair: insights from experimental models. Thromb Haemost. 2010; 104(1):30-8. PubMed PMID: 20539906.

Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG (2010). Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. Biophys J. 2010; 98(10):2063-71. PubMed PMID: 20483313; PMCID: PMC2872265.

Akar FG (2010). Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure. Minerva Cardioangiol. 2010; 58(2):205-12. PubMed PMID: 20440250.

Akar FG (2010). Use-dependent modulation of myocardial conduction by a new class of HERG agonists: deal breaker or cherry on top? J Cardiovasc Electrophysiol. 2010; 21(8):930-2. PubMed PMID: 20367661.

Hesketh GG, Shah MH, Halperin VL, Cooke CA, Akar FG, Yen TE, Kass DA,Machamer CE, Van Eyk JE, Tomaselli GF (2010). Ultrastructure and regulation oflateralized connexin43 in the failing heart. Circ Res. 2010; 106(6):1153-63. PubMed PMID: 20167932; PubMed Central PMCID: PMC2896878.

Xie C, Akar FG (2010). Mitochondrial dysfunction: a new frontier in the search forelusive arrhythmia mechanisms. Front Physiol. 2010; 1:163. doi:10.3389/fphys.2010.00163. PubMed PMID: 21423398; PubMed Central PMCID: PMC3059956.

Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG (2010). Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. FASEB J. 2010; 24 (2):451-63. PubMed PMID: 19825979; PubMed Central PMCID: PMC2812033.

Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O’Rourke B, Akar FG,Tomaselli GF (2009). Na+ channel regulation by Ca2+/calmodulin andCa2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res. 2010; 85 (3):454-63. PubMed PMID: 19797425; PubMed Central PMCID: PMC2802203.

2009

Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L, O’Rourke B (2009). From mitochondrial dynamics to arrhythmias. Int J Biochem Cell Biol. 2009; 41 (10):1940-8. PubMed PMID: 19703656; PMCID: PMC2732583.

Akar FG, Clancy CE (2009). Arrhythmia models: in vivo, in vitro and in silico. Drug Discov Today Dis Models. 2009; 6(3):55-56. PubMed PMID: 21072326; PubMed Central PMCID: PMC2976541.

Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, AbrahamTP, O’Rourke B, Akar FG, Kass DA, Tomaselli GF (2009). Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation. 2009; 119 (9):1220-30. PubMed PMID: 19237662; PubMed Central PMCID: PMC2703676.

2008

Gao Z, Barth AS, DiSilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA,Winslow RL, Tomaselli GF (2008). Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiol Genomics. 2008; 35(3):222-30. PubMed PMID: 18780759; PMCID: PMC2585017.

Jin H, Lyon AR, Akar FG (2008). Arrhythmia mechanisms in the failing heart. Pacing Clin Electrophysiol. 2008; 31(8):1048-56. PubMed PMID: 18684263.

Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA,Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeteddeletion of kcne2 impairs ventricular repolarization via disruption of I K,slow1 and Ito,f. FASEB J. 2008; 22(10):3648-60. PubMed PMID: 18603586; PubMed Central PMCID: PMC2537427.

Nass RD, Aiba T, Tomaselli GF, Akar FG (2008). Mechanisms of disease: ion channel remodeling in the failing ventricle. Nat Clin Pract Cardiovasc Med. 2008; 5(4):196-207. PubMed PMID: 18317475.

Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O’Rourke B (2008). Effects of4′-chlorodiazepam on cellular excitation-contraction coupling andischaemia-reperfusion injury in rabbit heart. Cardiovasc Res. 2008; 79(1):141-9. PubMed PMID: 18304929; PubMed Central PMCID: PMC2562874.

2007

Akar JG, Akar FG (2007). Regulation of ion channels and arrhythmias in the ischemic heart. J Electrocardiol. 2007; 40 (6 Suppl):S37-41. PubMed PMID: 17993326.

Akar FG (2007). The perfect storm: defective calcium cycling in insulated fiberswith reduced repolarization reserve. Circ Res. 2007; 101(10):968-70. PubMed PMID: 17991890.

Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D,Tunin RS, Kass DA, Tomaselli GF (2007). Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2007; 293(2):H1223-30. PubMed PMID: 17434978.

Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, LiRA (2006). Bioartificial sinus node constructed via in vivo gene transfer of anengineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation. 2006; 114(10):1000-11. PubMed PMID: 16923751.

2006

Akar JG, Akar FG (2006). Mapping arrhythmias in the failing heart: from Langendorff to patient. J Electrocardiol. 2006; 39 (4 Suppl):S19-23. PubMed PMID: 16920143.

Aon MA, Cortassa S, Akar FG, O’Rourke B (2006). Mitochondrial criticality: a newconcept at the turning point of life or death. Biochim Biophys Acta. 2006;62(2):232-40. PubMed PMID: 16242921; PubMed Central PMCID: PMC2692535. 

2005

Akar FG, Aon MA, Tomaselli GF, O’Rourke B. The mitochondrial origin ofpostischemic arrhythmias. J Clin Invest. 2005; 115(12):3527-35. PubMed PMID: 16284648; PubMed Central PMCID: PMC1280968.

Shah M, Akar FG, Tomaselli GF (2005). Molecular basis of arrhythmias. Circulation. 2005; 112(16):2517-29. PubMed PMID: 16230503.

Akar FG, Tomaselli GF (2005). Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences. Trends Cardiovasc Med. 2005; 15 (7):259-64. PubMed PMID: 16226681.

Akar FG, Tomaselli GF (2005). Ion channels as novel therapeutic targets in heartfailure. Ann Med. 2005; 37 (1):44-54. PubMed PMID: 15902846.

Spragg DD*, Akar FG* (1st co-authors), Helm RH, Tunin RS, Tomaselli GF, Kass DA (2005). Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res. 2005; 67(1):77-86. PubMed PMID: 15885674.

Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W,Armoundas AA, Tomaselli GF (2005). Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. Am J Physiol Heart Circ Physiol. 2005; 288(6):H2887-96. PubMed PMID: 15681701.

Xue T*, Cho HC*, Akar FG* (co-first authors), Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation. 2005; 111 (1):11-20. PubMed PMID: 15611367.

2004

Akar FG, Spragg DD, Tunin RS, Kass DA, Tomaselli GF (2004). Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res. 2004; 95 (7):717-25. PubMed PMID: 15345654.

Poelzing S, Akar FG, Baron E, Rosenbaum DS (2004). Heterogeneous connexin43expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004; 286 (5):H2001-9. PubMed PMID: 14704225. 

Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V 3rd, Houser SR,Tomaselli GF (2003). Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol. 2004; 286(2):H602-9. PubMed PMID: 14527940.

1998-2003

Akar FG, Rosenbaum DS (2003). Transmural electrophysiological heterogeneitiesunderlying arrhythmogenesis in heart failure. Circ Res. 2003; 93(7):638-45. PubMed PMID: 12933704.

Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS (2002). Unique topographicaldistribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002; 105(10):1247-53. PubMed PMID: 11889021.

Akar FG, Roth BJ, Rosenbaum DS (2001). Optical measurement of cell-to-cell coupling in intact heart using subthreshold electrical stimulation. Am J Physiol Heart Circ Physiol. 2001; 281(2):H533-42. PubMed PMID: 11454554.

Akar FG, Laurita KR, Rosenbaum DS (2000). Cellular basis for dispersion ofrepolarization underlying reentrant arrhythmias. J Electrocardiol. 2000; 33Suppl: 23-31. PubMed PMID: 11265727.

Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS (1999). Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999 Mar 16; 99(10):1385-94. PubMed PMID: 10077525.

Laurita KR, Girouard SD, Akar FG, Rosenbaum DS (1998). Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation. 1998 Dec 15; 98(24):2774-80. PubMed PMID: 9851966.