Molecular, Cellular, network, and Behavioral Mechanisms of Neurological Disorders and Therapeutic Development
The goal of the Yue Laboratory is to elucidate molecular, cellular, network, and behavioral mechanisms of neurological disorders. The Yue Laboratory employs a wide range of experimental and bioinformatic approaches, such as genetic, biochemical, molecular, cellular, transcriptomic (single cell RNAseq), proteomic, network, imaging (live and fixed), animal pathology/behavior, human iPSC neurons/glia and postmortem tissue analysis to dissect autophagy-lysosome, synaptic vesicle trafficking, cell metabolism, neuroinflammation, and protein/lipid kinase signaling in the neuropathogenesis. Our ultimate goal is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics.
Cell-type specific transcriptomics, molecular pathways and novel therapeutic target identification for Parkinson’s disease (PD)
Genetic linkage and genome wide association studies (GWAS) have begun to gain insight into the molecular mechanism of the PD. However, the vast majority of PD cases have no known genetic cause, and their etiology remains unclear. To dissect molecular mechanisms for dopamine (DA) neuron degeneration, post-GWAS research should investigate in what cell-type PD-linked genes or GWAS variants are actively expressed and how they are affected in vulnerable brain regions of PD. We aim to profile, validate, and characterize molecularly distinct neuron and glia types of PD by using three different biological systems: human postmortem tissues (e.g. SNpc and PFC), genetic mouse models, and induced human neurons (iPSC) 2D/3D midbrain cultures. We will conduct three highly integrated projects: (1) Validating and characterizing distinct DA neuron populations and their PD-associated vulnerability in mouse models through mouse genetics, transcriptomics, whole brain imaging and behavioral analysis; (2) Characterizing molecularly distinct DA neuron populations and their vulnerability in the SN of PD by multiplex RNA and protein spatial profiling, molecular anatomical analysis, and volumetric imaging; (3) Modeling and characterizing human DA neuron subpopulations and their PD-associated vulnerability identified from human SN by using hiPSC-based models.
Circuitry and inflammation mechanism in body-brain interactions during the progression of Parkinson’s disease
An increased incidence of PD in patients with inflammatory bowel disease (IBD), a chronic disease of the gut, has also been reported world-wide. With the finding of a-synuclein-associated Lewy body in peripheral tissues (e.g. gut) of PD patients, there is a growing appreciation for the hypothesis of gut-brain axis and chronic inflammation in the disease onset and progression for PD. The link between intestinal inflammation and PD is also enforced by elevated markers of intestinal inflammation, We aim to determine the subtypes of PD associated with prodromal gut chronic inflammation, dissect the pathogenic mechanism underpinning gut-brain axis, and identify molecular biomarkers and novel therapeutics for subtypes of PD. We will test the hypothesis that (1) chronic inflammation in the gastrointestinal system contributes to a subset of PD, and this is mediated by pathogenic interaction between LRRK2 and a-synuclein; (2) LRRK2 acts as an interface for the signaling pathways that leads to PD and inflammatory bowel disease (IBD), and investigation of LRRK2 targets (e.g. small GTPase Rab proteins) will help elucidate the molecular mechanisms for the gut-brain axis in the pathogenesis of PD. Our study will provide insight into the PD biomarker development.
The role of microglial autophagy in preventing senescence and offering neuroprotection in Alzheimer’s disease animal models
Autophagy is evolutionarily conserved lysosomal degradation system of the cell. It is a critical pathway that controls cellular homeostasis and can be activated in response to cellular injury or stress. Autophagy is regulated distinctively in different cell types and strongly linked to the pathogenic pathways for neurodegenerative diseases. Our goals are to determine neuroprotective mechanism conferred by microglial autophagy and understand how dysfunctional autophagy in microglia contributes to the pathogenesis of Alzheimer’s disease (AD). Our central hypothesis is that autophagy activation is required for disease associated microglia (DAM) metabolic fitness, prevention of senescence, and protection of neurons in the AD brains. We will investigate the role of microglial autophagy in controlling inflammation by selective degradation of inflammasomes via protein receptors that are neuroprotective in AD. In addition, we will develop therapeutic strategy to remove senescent microglia for neuroprotection during ageing and disease process.
Autophagy biology in the brain and its dysfunctions in neurons and glial cells in the pathogenesis of Alzheimer’s, Parkinson’s and Huntington’s disease
We propose to elucidate the landscape of autophagy process in the brains. We will investigate cell-type specific autophagy pathways (neuron vs. microglia) under physiological (young and old) and pathological conditions (AD, PD and HD). We will perform a systemic study that integrates multiple genetic mutant lines of mice, human induced neuron lines (hiN), quantitative proteomics, and molecular and cell biology to identify autophagy cargo and receptors in neurons and microglia. We will identify novel autophagy cargo and receptors in mediating autophagy functions in an age and neuron-type specific manner. We will also investigate the distinct mechanisms for the degradation of multiple disease-associated proteins such as tau, aSyn and huntingtin. Our study will pave the way to identify novel therapeutic targets of autophagy in the treatment of Alzheimer’s, Parkinson’s and Huntington’s disease.
Autophagy Receptor AKAP11, PKA activity regulation in neurons, and psychiatric disease (schizophrenia and bipolar)
Recent human genetic study has identified AKAP11 as a significant risk gene for bipolar disorder shared with schizophrenia. Our study demonstrated AKAP11 is an autophagy receptor that mediates selective degradation of PKA inhibitory subunit R1a through autophagy. Our goal is to dissect the pathogenic mechanism whereby AKAP11 deficiency predispose to the psychiatric illness by characterizing genetic animal models and establish a novel bipolar animal model. We will test new therapeutic ideas by targeting autophagy receptor AKAP11 and PKA activity.
Zhenyu Yue, PhD
*Professor of Neurology and Neuroscience
*Alex and Shirley Aidekman Family Professorship
*Director, Center for Parkinson’s disease Neurobiology
*Director, Basic and Translational Research of Movement Disorder
- November 10th~15th, 2023 Dr.Yue, Insup Choi, Xingjian Li, Bik Tzu Huang, Henry Kim, Marianna Liang, and Linh Chu presented their research at the SFN Conference https://www.sfn.org/meetings/neuroscience-2023/registration
- November 15th, 2023, Congratulations to Linh Chu on receiving the Trainee Professional Development Award from the Society for Neuroscience (SfN)
- November 2023 Congratulations on George Heaton’s grant from the New York Community Trust
- October 2023 Congratulations to Linh on being selected as a recipient of the 2023 Trainee Professional Development Award for SfN 2023
- May 26th, 2023 Congratulations to Xiaoting on her successful Ph.D. thesis defense.
- May 25th, 2023, Congratulations on Insup Choi’s paper published in Nature Cell Biology.https://www.nature.com/articles/s41556-023-01158-0
- May 12th, 2023, Dr. Yue and a lab member participate in The Friedman Brain Institute @2023 Neuroscience Retreat https://friedmanbrain.icahn.mssm.edu/retreat-23/
- May 1st, 2023, Congratulations on Insup Choi‘s K01 grant from (NIA/NIH)
- Mar 7th, 2023, Welcome to Yue lab, Linh Chu. Linh has started her dissertation research in Yue lab
- Dr. Yue, Insup Choi, You-Kyung Lee, and Xiaoting Zhou presented their research at the @Keystone Conference Autophagy and Neurodegeneration: Mechanisms to Therapies (March. 26~29, 2023)https://www.keystonesymposia.org/conferences/conference-listing/meeting?eventid=6812
- View our blog on the Parkinson’s Foundation Website! Link: Newest Parkinson’s Foundation Research Center Explores Dopamine Nerve Diversity in Parkinson’s | Parkinson’s Foundation
- Bik Tzu and Marianna presented their research (poster session) at the SfN meeting.
- Congratulations on Insup Choi’s recent review paper published in Science Advances.
- Congratulations to Dr. Yue and his team for having a $2 Million Research Center Grant from the Parkinson’s Foundation (title: Profiling and Elucidating Molecular Mechanism of Neurodegeneration in Parkinson’s disease) https://bit.ly/3yjbG86
- Sep 22nd, 2022, Congratulations to Bik Tzu Huang on receiving Trainee Professional Development Award from the Society for Neuroscience (SfN)
- Sep 9th, 2022, Insup Choi presented his study “Investigation of senescent microglia on Alzheimer’s disease” at the REC seminar of ADRC
- July 1st, 2022, Congratulations to Insup Choi. Insup has been promoted to Assistant Professor in Yue lab
- July 1st, 2022, Congratulations to George Heaton on winning the best poster award in LRRK2 conference
- June 27th, 2022, Welcome to Yue lab, Ted Wickstead. Ted has started his post-doctoral research in Yue lab
- May 27th, 2022, Congratulations to Bik Tzu on becoming a T32 trainee by the Department of Pharmacological Science
- May 13th, 2022, Congratulations to Insup Choi on winning the oral presentation award at the 14th FBI Neuroscience Retreat
- Mar 7th, 2022, Welcome to Yue lab, Marianna Liang. Marianna has started her dissertation research in Yue lab
- Jan 26th, 2022, Congratulations to Ravi Ghotra on his successful graduate thesis defense
- Jan 10th, 2022, Congratulations to Dr. Insup Choi on winning the ADRC grant (Alzheimer Disease Research Center of Mount Sinai)
- Nov 1st, 2021, Welcome to Yue lab, Heesoo Kim has joined Yue lab as Associate Researcher
- Aug 23rd, 2021, Welcome to Yue lab, You-Kyung Lee has started her post-doctoral research in Yue lab
- May 17th, 2021, Welcome to Yue lab, Bik Tzu Huang. Bik Tzu Huang has started her dissertation research in Yue lab
- May 13th, 2021, Congratulations to Shiyi on the completion of his training in Yue lab and heading back to China for his thesis defense
- May 10th, 2021, Congratulations to Steven Seegobin on his admission to LECOM medical school!!!
- Apr 2nd, 2021, Researchers in Yue lab have found a novel therapeutic target for specific cancer treatment, here is the details
- Jan 27th, 2021, Lab member Steven Seegobin gave a talk titled “Maintenance of Alpha-Synuclein Homeostasis by Microglia in Parkinson’s Disease” at the ADND/Loeb WIP seminar.
- Jan 23rd, 2021, Congratulations to Dongxiao on her successful doctorate defense, you well deserved it, Dr. Liang.
- Jul 1st, 2020, the latest update on Autophagy’s role by Prof. Yue, here are the details
- Jun 2nd, 2020, Congratulations to Steven Seegobin, his PD animal review paper was accepted by Front Neuroscience, here are the details
- Oct 1st, 2020, Congratulations to George Heaton!, Dr. Heaton has won first place in 2020 Poster Presentation Award at Morris K. Udall Centers of Excellence for Parkinson’s disease research.
- Sep 1st, 2019, Congratulations to Insup Choi! Dr. Choi has won first place in 2019 Poster Presentation Award at Morris K. Udall Centers of Excellence for Parkinson’s disease research.
- Nov 1st, 2011, Pioneering Research of Autophagy at Yue Lab
- Mar 25th, 2011, Mount Sinai Researchers Uncover How a Gene Mutation Causes Parkinson’s Disease.
Post-Doctoral Fellow – Neurodegenerative Disease’s Mechanisms (PD, AD, and HD) (multiple positions)
The laboratory of Professor Zhenyu Yue is looking for highly motivated and collaborative postdoctoral fellows to join Friedman Brain Institute at Icahn School of Medicine at Mount Sinai in New York City.
Multiple positions are available for highly motivated and ambitious scientists to use a wide range of experimental and bioinformatic approaches to investigate the pathogenic mechanisms of neurodegenerative diseases such as Parkinson’s, Alzheimer’s and Huntington’s diseases. The lab employs mouse genetics, biochemical, molecular, cellular, transcriptomic (snRNAseq), proteomic, network, imaging (live and fixed), animal pathology/behavior, human iPSC neurons/glia and postmortem tissue analysis to dissect autophagy-lysosome, synaptic vesicle trafficking, cell metabolism, neuroinflammation, and protein/lipid kinase signaling in the neuropathogenesis.
- A recent Ph.D. graduate with demonstrated experience in any of the following fields: cell biology, molecular biology, mouse genetics, biochemistry, neuroscience, and/or systems biology.
- The ideal candidates will have experience in any of the following research areas: molecular and cell biology in neuronal and/or glial culture models; confocal and/or stereological microscopy; protein biochemistry, proteomics; viral vector technology; development of genetic animal models; rodent neuropathology and behavior; bioinformatic, single cell/nuclei RNAseq, iPSC derived neurons/glia,
Please submit your online application with the following:
- Cover letter outlining research experience and interests
- Curriculum Vitae
- Contact details for 3 references
Questions may be directed to Dr. Zhenyu Yue (firstname.lastname@example.org)
- Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang & Zhenyu Yue. Nat Cell Biology. 2023 May 25. doi: 10.1038/s41556-023-01158-0.
Regulation of α-Synuclein Homeostasis and Inflammasome Activation by Microglial Autophagy. Insup Choi, George R. Heaton, You-Kyung Lee, and Zhenyu Yue (2022) Science Advances. Oct 28;8(43):eabn1298. doi: 10.1126/sciadv.abn1298.
Pharmacological modulation of autophagy for Alzheimer’s disease therapy: Opportunities and obstacles. Deng Z, Dong Y, Zhou X, Lu JH, Yue Z. Acta Pharm Sin B. 2022 Apr;12(4):1688-1706. doi: 10.1016/j.apsb.2021.12.009. Epub 2021 Dec 18.PMID: 35847516 Free PMC article. Review.
- Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su H, Wang XJ, Iyaswamy A, Yue Z, Wang Q, Zhang B, Xue Y, Tan J, Li M, He H, Lu JH. Theranostics. 2022 Jan 24;12(4):1738-1755. doi: 10.7150/thno.64148. eCollection 2022.PMID: 35198070
- Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth. Proc Natl Acad Sci.
- Wang Q, Zhang B, and Yue Z (2021). Disentangling the Molecular Pathways of Parkinson’s Disease using Multiscale Network Modeling Trends in Neuroscience
- Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, Neff R, Song WM, Wang E, Shen Q, Zhou X, Ming C, Ho SM, Vatansever S, Kaniskan U, Jin J, Zhou MM, Ando K, Ho L, Slesinger PA, Yue Z, Zhu J, Katsel P, Gandy S, Ehrlich ME, Fossati V, Noggle S, Cai D, Haroutunian V, Iijima KM, Schadt E, Brennand KJ, and Zhang B (2021). Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease. Neuron.
- Autophagy and Parkinson’s Disease. Adv Exp Med Biol. (2020).
- Zhao Y, Qin L, Pan H, Liu Z, Jiang L, He Y, Zeng Q, Zhou X, Zhou X, Zhou Y, Fang Z, Wang Z, Xiang Y, Yang H, Wang Y, Zhang K, Zhang R, He R, Zhou X, Zhou Z, Yang N, Liang D, Chen J, Zhang X, Zhou Y, Liu H, Deng P, Xu K, Xu K, Zhou C, Zhong J, Xu Q, Sun Q, Li B, Zhao G, Wang T, Chen L, Shang H, Liu W, Chan P, Xue Z, Wang Q, Guo L, Wang X, Xu C, Zhang Z, Chen T, Lei L, Zhang H, Wang C, Tan J, Yan X, Shen L, Jiang H, Zhang Z, Hu Z, Xia K, Yue Z, Li J, Guo J, Tang B (2020). The Role of Genetics in Parkinson’s Disease: A Large Cohort Study in Chinese Mainland Population Brain.
- Wu JH, Li YN, Chen AQ, Hong CD, Zhou YF, Li PC, Y, Mao L, Xia YP, He QW, Jin HJ, Yue Z, and Hu B (2020). Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy. EMBO Molecular Medicine.
- Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B & Yue Z (2020). Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications.
- Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z (2019). Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Molecular Neurodegeneration.
- Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z*, Zhang B* (2019). The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease. Nature Communications.
- Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, Chen SG, Elliott CJ, Rideout H, Ubarretxena-Belandia I, Yue Z (2019). Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. Cell Research.
- Lee YA, Noon LA, Lee T, Akat KM, Chou HI, Berres ML, Fiel MI, Gordon R, Pfleger C, Germain D, Khambu B, Yin XM, Campbell K, Yue Z, Kramer E, John G, Czaja MJ, Hoshida Y and Friedman SL(2018). Autophagy is a Gatekeeper of Hepatic Differentiation and Carcinogenesis by Controlling the Degradation of Yap. Nature communications.
- Yang N and Yue Z(2018). A Peek of Parkinson’s Disease Progression through Human Dopamine Neuron in a Dish. Trends in Neuroscience.
- Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe’er I, Ioannou Y, P. B. McGovern D, Yue Z, Schadt EE, Cho JH, and Peter I (2018). Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease. Science Translational Medicine.
- Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, and Zhou Z (2018). Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology. Nature Communications.
- Wu S, He Y, Yang W, Liu W, Li X, Qiu X, Li Y, Shen HM, Wang R, Yue Z, and Zhao Y (2018). Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proceedings of the National Academy of Sciences.
- Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PKA, Boldt K, Zweydorf FV, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A and Gloeckner CJ(2016). A structural model of the Parkinson’s Disease protein LRRK2 provides insight into the intramolecular regulation of its kinase activity. Proceedings of the National Academy of Sciences.
- Deng Z, Purtell K, Lachance V, Wold M, Chen S, and Yue Z (2017). Autophagy receptors and Neurodegeneration. Trends in Cell Biology.
- Lu J, He L, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z (2014). NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature communications.
- Yamamoto A and Yue Z (2014). Autophagy and its Normal and Pathogenic States in the Brain. Annual Reviews of Neuroscience.
- Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D (2014). Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits. Neuron.
- Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH (2014). Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science.
- Lim J, Yue Z (2015). Neuronal Aggregates: Formation, Clearance, and Spreading. Developmental Cell.
- Yue Z and Yang XW (2013). Dangerous duet: LRRK2 and alpha-synuclein jam at CMA. Nature Neuroscience.
- Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013). Autophagy in axonal and dendritic degeneration. Trends in Neuroscience.
- Friedman L, Lachenmayer L, Wang J, He L, Poulose S, Komatsu M, Holstein G, Yue Z (2012). Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain. The Journal of Neuroscience.
- Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S (2012). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model. Molecular Psychiatry.
- Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z*, Zhao Y* (2012). Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nature Communications.
- Sheng Z, Zhang S, Butos D, Kleinheinz T, Le Pichon CE, Domingues S, Solanoy HO, Drummond J, Zhang X, Ding X, Li X, Yue Z, Liu X, Burkick DJ, Estrada AA, Gunzner-Toste J, Chen H, Sweeney ZK, Sceace-Levie K, Moffat JG, Kirkpatick DS, Zhu H (2012). Autophosphorylation of Serine on LRRK2 is an in vivo biomarker of kinase activity and is required for LRRK2-induced neuronal toxicity. Science Translational Medicine.
- Funderburk SF, Wang QJ, and Yue Z (2010). The Beclin 1-VPS34 complex – at the crossroads of autophagy and beyond. Trends in Cell Biology.
- Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z (2010). Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson’s disease mutation G2019S. The Journal of Neuroscience.
- Zhong Y, Wang QJ, Li X, Chait BT, Heintz N, and Yue Z (2009). Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. Nature Cell Biology.
- Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K (2007). Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell.
- Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z (2007). Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proceedings of the National Academy of Sciences.
- Wang QJ, Ding Y, Kolhz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z (2006). Induction of autophagy in axonal dystrophy and degeneration. The Journal of Neuroscience.
- Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003). Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. Proceedings of the National Academy of Sciences.
- Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (2002). A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. Neuron.
Zhenyu Yue, PhD
Aidekman Family Professorship
Professor of Neurology and Neuroscience
Research Topic: Parkinson’s disease
Research Topic: Neurodevelopmental disorder, Neurodegenerative disease
Undergraduate research intern
Research Topic: Autophagy, neuronal autophagy
We accept rotation students from Mount Sinai PhD, MD-PhD, MD, & MS programs
For postdoc position, please contact
One Gustave L. Levy Place
New York, NY 10029
1470 Madison Avenue
Hess Center 9-201, 202 (lab), 9-106 (office)
New York, NY 10029