Welcome to the Yue Laboratory

The mission of the Yue Laboratory is to elucidate molecular, cellular and network mechanisms of neurodegeneration underlying human neurodegenerative diseases such as Parkinson’s, Huntington’s, Alzheimer’s disease. The Yue Laboratory employs a wide range of experimental and bioinformatic approaches, such as genetic, biochemical, molecular, cellular, transcriptomic (single cell RNAseq), proteomic, network, imaging (live and fixed), animal pathology/behavior, human iPSC neurons/glia and postmortem tissue analysis to dissect autophagy-lysosome, synaptic vesicle trafficking, cell metabolism, neuroinflammation, and protein/lipid kinase signaling in the neuropathogenesis. Our ultimate goal is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for the above neurological disorders.