The mission of the Yue Laboratory is to elucidate molecular, cellular and network mechanisms of neurodegeneration underlying human neurodegenerative diseases such as Parkinson’s, Huntington’s, Alzheimer’s disease. The Yue Laboratory employs a wide range of experimental and bioinformatic approaches, such as genetic, biochemical, molecular, cellular, transcriptomic (single cell RNAseq), proteomic, network, imaging (live and fixed), animal pathology/behavior, human iPSC neurons/glia and postmortem tissue analysis to dissect autophagy-lysosome, synaptic vesicle trafficking, cell metabolism, neuroinflammation, and protein/lipid kinase signaling in the neuropathogenesis. Our ultimate goal is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for the above neurological disorders.