Selected papers

Xu J, Zhou X, Zhang T, Zhang B, Xu PX. Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development. Front Cell Dev Biol. 2023 Sep 4:11:1233317. doi: 10.3389/fcell.2023.1233317. eCollection 2023. PubMed PMID: 37727504; PMCID:PMC10506413.

Zhang T, Xu PX. Six1 The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood. Front Cell Dev Biol. 2023 Apr 25:11:1126968. doi: 10.3389/fcell.2023.1126968. eCollection 2023. PubMed PMID: 37181748; PMCID:PMC10167055.

Li J, Cheng, C, Xu J, Zhang T, Tokat, B, Dolios G, Ramakrishnan A, Shen L, Wang R, Xu PX. the transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity. Nucleic Acids Res. 2020 Apr 6;48(6):2880-2896. doi: 10.1093/nar/gkaa012. PubMed PMID: 31956913; PMCID: PMC7102962. Nucleic Acids Res. 2022 Oct 14;50(18):10343-10359. doi: 10.1093/nar/gkac760. PubMed PMID: 36130284; PMCID: PMC9561260.

Xu J, Li J, Ramakrishnan A, Yan H, Shen L, Xu PX. Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation. Front Cell Dev Biol. 2022;10:815249. doi: 10.3389/fcell.2022.815249. eCollection 2022. PubMed PMID: 35178390; PMCID:PMC8844495.

Li J, Xu J, Jiang H, Zhang T, Ramakrishnan A, Shen L, Xu PX. Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance. J Am Soc Nephrol. 2021 Nov;32(11):2815-2833. doi: 10.1681/ASN.2021040525. PubMed PMID: 34716243; PMCID:PMC8806105.

Zhang T, Xu J, Xu PX. Eya2 expression during mouse embryonic development revealed by Eya2^lacZ knockin reporter and homozygous mice show mild hearing loss. Dev Dyn. 2021 Oct;250(10):1450-1462. doi: 10.1002/dvdy.326. Epub 2021 Mar 19. PubMed PMID: 33715274; PMCID:PMC8438093.

Xu B, Yang Q, Tang Y, Tan Z, Fu H, Peng J, Xiang X, Gan L, Deng G, Mao Q, Xu PX, Jiang Y, Ding J. SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases. Ann Transl Med. 2021 Jun;9(12):992. doi: 10.21037/atm-21-2526. PubMed PMID: 34277792; PMCID: PMC8267256.

Xu J, Li J, Zhang T, Jiang H, Ramakrishnan A, Fritzsch B, Shen L, Xu PX. Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12). doi: 10.1073/pnas.2025196118. PubMed PMID: 33723076; PMCID: PMC8000026.

Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA. The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors. Dev Neurosci. 2020;42(5-6):170-186. doi: 10.1159/000512976. Epub 2021 Jan 20. PubMed PMID: 33472197; PMCID: PMC8118085.

Chang E, Fu C, Coon SL, Alon S, Bozinoski M, Breymaier M, Bustos DM, Clokie SJ, Gothilf Y, Esnault C, Michael Iuvone P, Mason CE, Ochocinska MJ, Tovin A, Wang C, Xu P, Zhu J, Dale R, Klein DC. Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina. J Pineal Res. 2020 Oct;69(3):e12673. doi: 10.1111/jpi.12673. Epub 2020 Jul 8. PubMed PMID: 32533862; PMCID: PMC7513311.

Yamoah EN, Li M, Shah A, Elliott KL, Cheah K, Xu PX, Phillips S, Young SM Jr, Eberl DF, Fritzsch B. Using Sox2 to alleviate the hallmarks of age-related hearing loss. Ageing Res Rev. 2020 May;59:101042. doi: 10.1016/j.arr.2020.101042. Epub 2020 Mar 12. Review. PubMed PMID: 32173536; PMCID: PMC7261488.

Li J, Zhang T, Ramakrishnan A, Fritzsch B, Xu J, Wong EYM, Loh YE, Ding J, Shen L, Xu PX. Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. Nucleic Acids Res. 2020 Apr 6;48(6):2880-2896. doi: 10.1093/nar/gkaa012. PubMed PMID: 31956913; PMCID: PMC7102962.

Xu WJ, Chen YQ, Xiao JF, Chen YM, Xu PX, Ding JQ. [Production of transgenic mice for alpha-1 antitrypsin deficiency disease]. Zhonghua Gan Zang Bing Za Zhi. 2018 Dec 20;26(12):955-957. doi: 10.3760/cma.j.issn.1007-3418.2018.12.015. PubMed PMID: 30669791.

Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH. An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife. 2017 Nov 15;6. doi: 10.7554/eLife.30126. PubMed PMID: 29140246; PMCID: PMC5705218.

Zhang T, Xu J, Maire P, Xu PX. Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium. PLoS Genet. 2017 Sep;13(9):e1006967. doi: 10.1371/journal.pgen.1006967. eCollection 2017 Sep. PubMed PMID: 28892484; PMCID: PMC5593176.

Xu J, Ueno H, Xu CY, Chen B, Weissman IL, Xu PX. Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti. Nat Commun. 2017 May 11;8:15046. doi: 10.1038/ncomms15046. PubMed PMID: 28492243; PMCID: PMC5437288.

Li J, Rodriguez Y, Cheng C, Zeng L, Wong EYM, Xu CY, Zhou MM, Xu PX. EYA1’s Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer. Mol Cell Biol. 2017 Jan 1;37(1). doi: 10.1128/MCB.00499-16. Print 2017 Jan 1. PubMed PMID: 27795300; PMCID: PMC5192086.

Wong EY, Xu CY, Brahmachary M, Xu PX. A Novel ENU-Induced Mutation in Myo6 Causes Vestibular Dysfunction and Deafness. PLoS One. 2016;11(5):e0154984. doi: 10.1371/journal.pone.0154984. eCollection 2016. PubMed PMID: 27171474; PMCID: PMC4865150.

Xu J, Xu PX. Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation. Dev Dyn. 2015 Jul;244(7):866-73. doi: 10.1002/dvdy.24282. Epub 2015 Jun 18. PubMed PMID: 25903664; PMCID: PMC4485534.

Cheah K, Xu P. SOX2 in Neurosensory Fate Determination. Sox2 Biology in Development and Disease. 2015; :263-280. Book chapter

Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell. 2015 Apr 6;33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26. PubMed PMID: 25816987; PMCID: PMC4418443.

Xu J, Wong EY, Cheng C, Li J, Sharkar MT, Xu CY, Chen B, Sun J, Jing D, Xu PX. Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell. 2014 Nov 24;31(4):434-47. doi: 10.1016/j.devcel.2014.10.015. Epub 2014 Nov 24. PubMed PMID: 25458011; PMCID: PMC4282136.

Yan J, Zhang L, Xu J, Sultana N, Hu J, Cai X, Li J, Xu PX, Cai CL. Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis. PLoS One. 2014;9(8):e104503. doi: 10.1371/journal.pone.0104503. eCollection 2014. PubMed PMID: 25127126; PMCID: PMC4134214.

Xu J, Nie X, Cai X, Cai CL, Xu PX. Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol. 2014 Jul 1;391(1):17-31. doi: 10.1016/j.ydbio.2014.04.006. Epub 2014 Apr 12. PubMed PMID: 24727670; PMCID: PMC4038151.

Xu PX. The EYA-SO/SIX complex in development and disease. Pediatr Nephrol. 2013 Jun;28(6):843-54. doi: 10.1007/s00467-012-2246-1. Epub 2012 Jul 19. Review. PubMed PMID: 22806561; PMCID: PMC6592036.

Bao S, Zhu L, Zhuang Q, Wang L, Xu PX, Itoh K, Holzman IR, Lin J. Distribution dynamics of recombinant Lactobacillus in the gastrointestinal tract of neonatal rats. PLoS One. 2013;8(3):e60007. doi: 10.1371/journal.pone.0060007. Epub 2013 Mar 27. PubMed PMID: 23544119; PMCID: PMC3609735.

Wong EY, Ahmed M, Xu PX. EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear. Hear Res. 2013 Mar;297:13-9. doi: 10.1016/j.heares.2012.09.009. Epub 2012 Oct 24. Review. PubMed PMID: 23104013; PMCID: PMC6592049.

Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol. 2013 Mar;33(5):927-36. doi: 10.1128/MCB.01516-12. Epub 2012 Dec 21. PubMed PMID: 23263983; PMCID: PMC3623089.

Rinkevich Y, Mori T, Sahoo D, Xu PX, Bermingham JR Jr, Weissman IL. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol. 2012 Dec;14(12):1251-60. doi: 10.1038/ncb2610. Epub 2012 Nov 11. PubMed PMID: 23143399; PMCID: PMC3685475.

Ahmed M, Xu J, Xu PX. EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development. 2012 Jun;139(11):1965-77. doi: 10.1242/dev.071670. Epub 2012 Apr 18. PubMed PMID: 22513373; PMCID: PMC3347689.

Ahmed M, Wong EY, Sun J, Xu J, Wang F, Xu PX. Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell. 2012 Feb 14;22(2):377-90. doi: 10.1016/j.devcel.2011.12.006. PubMed PMID: 22340499; PMCID: PMC3285434.

Nie X, Xu J, El-Hashash A, Xu PX. Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol. 2011 Apr 1;352(1):141-51. doi: 10.1016/j.ydbio.2011.01.027. Epub 2011 Jan 31. PubMed PMID: 21281623; PMCID: PMC3113441.

Sun J, Tang T, Duan J, Xu PX, Wang Z, Zhang Y, Wu L, Li Y. Biocompatibility of bacterial magnetosomes: acute toxicity, immunotoxicity and cytotoxicity. Nanotoxicology. 2010 Sep;4(3):271-83. doi: 10.3109/17435391003690531. PubMed PMID: 20795909.

Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B. Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 2010 Aug 20;10:89. doi: 10.1186/1471-213X-10-89. PubMed PMID: 20727173; PMCID: PMC2939565.

Nie X, Sun J, Gordon RE, Cai CL, Xu PX. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development. 2010 Mar;137(5):755-65. doi: 10.1242/dev.045757. Epub 2010 Jan 28. PubMed PMID: 20110314; PMCID: PMC2827686.

 Chen B, Kim EH, Xu PX. Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. Dev Biol. 2009 Feb 1;326(1):75-85. doi: 10.1016/j.ydbio.2008.10.039. Epub 2008 Nov 7. PubMed PMID: 19027001; PMCID: PMC7058120.

Zou D, Erickson C, Kim EH, Jin D, Fritzsch B, Xu PX. Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56. doi: 10.1093/hmg/ddn229. Epub 2008 Aug 4. PubMed PMID: 18678597; PMCID: PMC2722896.

Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F. Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet. 2007 Apr;80(4):800-4. doi: 10.1086/513322. Epub 2007 Feb 22. PubMed PMID: 17357085; PMCID: PMC1852719.

Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX, Maire P. Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16. doi: 10.1016/j.ydbio.2006.08.059. Epub 2006 Sep 1. PubMed PMID: 17098221.

 Zou D, Silvius D, Rodrigo-Blomqvist S, Enerbäck S, Xu PX. Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev Biol. 2006 Oct 15;298(2):430-41. doi: 10.1016/j.ydbio.2006.06.049. Epub 2006 Jul 7. PubMed PMID: 16916509; PMCID: PMC3882145.

Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX. Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512. doi: 10.1016/j.ydbio.2005.12.015. Epub 2006 Mar 10. PubMed PMID: 16530750; PMCID: PMC3882147.

Sajithlal G, Zou D, Silvius D, Xu PX. Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol. 2005 Aug 15;284(2):323-36. doi: 10.1016/j.ydbio.2005.05.029. PubMed PMID: 16018995; PMCID: PMC3876955.

 Zou D, Silvius D, Fritzsch B, Xu PX. Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development. 2004 Nov;131(22):5561-72. doi: 10.1242/dev.01437. Epub 2004 Oct 20. PubMed PMID: 15496442; PMCID: PMC3882150.

Grifone R, Laclef C, Spitz F, Lopez S, Demignon J, Guidotti JE, Kawakami K, Xu PX, Kelly R, Petrof BJ, Daegelen D, Concordet JP, Maire P. Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol Cell Biol. 2004 Jul;24(14):6253-67. doi: 10.1128/MCB.24.14.6253-6267.2004. PubMed PMID: 15226428; PMCID: PMC434262.

 Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM Jr, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8090-5. doi: 10.1073/pnas.0308475101. Epub 2004 May 12. PubMed PMID: 15141091; PMCID: PMC419562.

 Zheng W, Huang L, Wei ZB, Silvius D, Tang B, Xu PX. The role of Six1 in mammalian auditory system development. Development. 2003 Sep;130(17):3989-4000. doi: 10.1242/dev.00628. PubMed PMID: 12874121; PMCID: PMC3873880.

 Escalier D, Bai XY, Silvius D, Xu PX, Xu X. Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant. Mol Reprod Dev. 2003 Jul;65(3):298-308. doi: 10.1002/mrd.10290. PubMed PMID: 12784252.

 Xu PX, Zheng W, Huang L, Maire P, Laclef C, Silvius D. Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94. doi: 10.1242/dev.00536. PubMed PMID: 12783782; PMCID: PMC3872112.

 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X. Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44. doi: 10.1242/dev.129.13.3033. PubMed PMID: 12070080; PMCID: PMC3873877.

Buller C, Xu X, Marquis V, Schwanke R, Xu PX. Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Hum Mol Genet. 2001 Nov 15;10(24):2775-81. doi: 10.1093/hmg/10.24.2775. PubMed PMID: 11734542.

 Xu X, Xu PX. A modified cryosection method for mouse testis tissue. Tissue Cell. 2001 Apr;33(2):208-10. doi: 10.1054/tice.2000.0150. PubMed PMID: 11392674.

 Sivak JM, Mohan R, Rinehart WB, Xu PX, Maas RL, Fini ME. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000 Jun 1;222(1):41-54. doi: 10.1006/dbio.2000.9694. PubMed PMID: 10885745.

 Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7. doi: 10.1038/12722. PubMed PMID: 10471511.

Matsunami K, Kokubo H, Ohno K, Xu P, Ueno K, Suzuki Y. Embryonic silk gland development in Bombyx: molecular cloning and expression of the Bombyx trachealess gene. Dev Genes Evol. 1999 Sep;209(9):507-14. doi: 10.1007/s004270050283. PubMed PMID: 10502107.

 Xu PX, Zhang X, Heaney S, Yoon A, Michelson AM, Maas RL. Regulation of Pax6 expression is conserved between mice and flies. Development. 1999 Jan;126(2):383-95. doi: 10.1242/dev.126.2.383. PubMed PMID: 9847251.

 Xu PX, Cheng J, Epstein JA, Maas RL. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11974-9. doi: 10.1073/pnas.94.22.11974. PubMed PMID: 9342347; PubMed Central PMCID: PMC23674.

 Xu X, Xu PX, Amanai K, Suzuki Y. Double-segment defining role of even-skipped homologs along the evolution of insect pattern formation. Dev Growth Differ. 1997 Aug;39(4):515-22. doi: 10.1046/j.1440-169x.1997.t01-3-00013.x. PubMed PMID: 9352206.

Kokubo H, Xu PX, Xu X, Matsunami K, Suzuki Y. Spatial and temporal expression pattern of POU-M1/SGF-3 in Bombyx mori embryogenesis. Dev Genes Evol. 1997 May;206(8):494-502. doi: 10.1007/s004270050080. PubMed PMID: 27747376.

Xu PX, Woo I, Her H, Beier DR, Maas RL. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31. doi: 10.1242/dev.124.1.219. PubMed PMID: 9006082.

Xu X, Xu PX, Suzuki Y. A maternal homeobox gene, Bombyx caudal, forms both mRNA and protein concentration gradients spanning anteroposterior axis during gastrulation. Development. 1994 Feb;120(2):277-85. doi: 10.1242/dev.120.2.277. PubMed PMID: 7908628.

Xu PX, Fukuta M, Takiya S, Matsuno K, Xu X, Suzuki Y. Promoter of the POU-M1/SGF-3 gene involved in the expression of Bombyx silk genes. J Biol Chem. 1994 Jan 28;269(4):2733-42. PubMed PMID: 8300605.

Fukuta M, Matsuno K, Hui CC, Nagata T, Takiya S, Xu PX, Ueno K, Suzuki Y. Molecular cloning of a POU domain-containing factor involved in the regulation of the Bombyx sericin-1 gene. J Biol Chem. 1993 Sep 15;268(26):19471-5. PubMed PMID: 7690034.