The Watanabe laboratory’s current projects include:

1) Identification of novel subsets of lung cancer defined by chromatin landscape on lineage factors

2) Development of a high-throughput methodology to profile a single cell chromatin landscape to uncover heterogeneity and plasticity of lung cancer

3) Understanding the roles of SOX2 and its interacting partners in lung squamous cell cancers and small cell lung cancers

4) Understanding the roles of MYC family members as a lineage factor in small cell lung carcinoma

5) Understanding the roles of NKX2-1 in small cell lung cancers