Cognitive consequences of stage-specific sleep apnea
In this project, we use stage-specific CPAP withdrawal in subjects with severe OSA to address questions about how sleep affects spatial navigational memory, and what the contributions are of sleep fragmentation versus intermittent hypoxia associated with OSA.
Brain sleep clearance of amyloid-beta peptides study (Brain SCRAPS)
In the first part of this study, we examine relationships between sleep characteristics and levels of proteins in spinal fluid that are associated with the development of Alzheimer disease in cognitively normal elderly subjects. In the second part, we examine the effects of CPAP withdrawal on levels of proteins in spinal fluid that are associated with the development of Alzheimer disease in subjects with severe OSA.
Molecular mechanisms of sleep-dependent motor learning and memory
In this project, we explore the roles of cortical sleep spindles and signaling pathways that support the synthesis of new neuronal proteins in the sleep-dependent augmentation of motor skill learning in animal models.