SELECTED PUBLICATIONS

* P16 immunohistochemistry is a sensitive and specific surrogate marker for CDKN2A homozygous deletion in gliomas. Vij M, Cho BB, Yokoda RT, Rashidipour O, Umphlett M, Richardson TE, and N.M. Tsankova. Acta Neuropathol Commun. 2023 May 3;11(1):73. PMID: 37138345

* Mismatch repair protein mutations in IDH-mutant astrocytoma and IDH-wildtype glioblastoma TE Richardson, RT Yokoda, O Rashidipour, M Vij, M Snuderl, S Brem, KJ Hatanpaa, SK McBrayer, KG Abdullah, M Umphlett, JM Walker, and N.M. Tsankova Neuro-Oncology Advances 2023 (accepted)

* The Prognostic Impact of Subclonal IDH1Mutation in Grade 2-4 Astrocytomas. M Vij,RT Yokoda, O Rashidipour, I Tran, V Vasudevaraja, M Snuderl, RL Yong, WS Cobb, M Umphlett, Jamie M Walker, N.M. Tsankova*, Timothy E Richardson* Neuro-Oncology Advances, Published: 29 May 2023. https://doi.org/10.1093/noajnl/vdad069.

Monocyte depletion enhances neutrophil influx and Proneural to Mesenchymal transition in Glioblastoma. Z. Chen, N. Soni, G. Pinero, B. Giotti, D.J. Eddins, K.E. Lindblad, JL Ross, M. Vallcorba, T. Joshi, A. Angione, W. Thomason, A. Keane, N.M. Tsankova, D.H. Gutmann, S.A. Lira, A. Lujambio, E.B. Ghosn, A.M. Tsankov, and D. Hambardzumyan Nature Communications March 2023

A phase I trial of VEGF-A inhibition combined with PD-L1 blockade for recurrent glioblastoma. D. Chiu, J. Qi, T. Thin, M. Garcia-Barros, B. Lee, M. Hahn, J. Mandeli, P. Belani, K. Nael, O. Rashidipour, S. Ghatan, C.G. Hadjipanayis, R.L. Yong, I.M. Germano, R. Brody, N.M. Tsankova, S. Gnjatic, S. Kim-Schulze, and A. Hormigo. Cancer Research Communications, 2023/1/10

Using EGFR amplification to stratify recurrent glioblastoma treated with immune checkpoint inhibitors. J. Friedman, T. Jun, O. Rashidipour, K-L. Huang, E. Ellis, P. Kadaba, P. Belani, K. Nael, N.M. Tsankova, R. Sebra, A. Hormigo. Cancer Immunol Immunother 2023 Jan 28

Multi-Parametric Radiomic Model to Predict 1p/19q Co-Deletion in Patients with IDH-1 Mutant Glioma: Added Value to the T2-FLAIR Mismatch Sign. S. Kihira, A. Derakhshani, M. Leung, K. Mahmoudi, A. Bauer, H. Zhang, J. Polson, C. Arnold, N.M. Tsankova, A. Hormigo, B. Salehi, N. Pham, BM Ellingson, TF Cloughesy, K. Nael. Cancers (Basel). 2023 Feb 7;15(4):1037

2022

* An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics. S.I. Ramos, Z.M. Mussa, E.N. Falk, B. Pai, B. Giotti, K. Allette, P. Cai, F. Dekio, R. Sebra, K.G. Beaumont, A.M. Tsankov, and N.M. Tsankova. Nature Communications. 2022 Dec 12; 13(1):7671

* High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy. Pai B, Tome-Garcia J, Cheng W, Nudelman G, Beaumont KG, Ghatan S, Panov F, Caballero E, Sarpong K, Marcuse L, Yoo J, Jiang Y, Schaefer A, Akbarian S, Sebra R, Pinto D, Zaslavsky E, N.M. Tsankova Acta Neuropathol Commun 2022

* IDH-mutant astrocytoma with EGFR amplification-Genomic profiling in four cases and review of literature. Umphlett M, Bilal KH, Martini ML, Suwala AK, Ahuja S, Rashidipour O, Germano I, Snuderl M, Morgenstern P, N.M. Tsankova. Neurooncol Adv. 2022 May 10;4(1)

A complete temporal transcription factor series in the fly visual system. Konstantinides N, Holguera I, Rossi AM, Escobar A, Dudragne L, Chen YC, Tran TN, Martínez Jaimes AM, Özel MN, Simon F, Shao Z, N.M. Tsankova, Fullard JF, Walldorf U, Roussos P, Desplan C. Nature. 2022 Apr; 604(7905):316-322.

Chromosomal instability in adult-type diffuse gliomas. Richardson TE, Walker JM, Abdullah KG, McBrayer SK, Viapiano MS, Mussa ZM, N.M. Tsankova, Snuderl M, Hatanpaa KJ. Acta Neuropathol Commun. 2022 Aug 17;10(1):115.

U-Net Based Segmentation and Characterization of Gliomas. Kihira S, Mei X, Mahmoudi K, Liu Z, Dogra S, Belani P, N. Tsankova, Hormigo A, Fayad ZA, Doshi A, Nael K. Cancers (Basel). 2022 Sep 14;14(18):4457.

2021

* Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor Verteporfin in preclinical glioblastoma models. Barrette AM, Ronk H, Joshi T, Mussa Z, Mehrotra M, Bouras A, Nudelman G, Houldsworth J, Yong R, Zaslavsky E, Hadjipanayis C.G., Birtwistle MR, N.M. Tsankova. Neuro-Oncology. 2022

* Isolation of Adult Human Astrocyte Populations from Fresh-frozen Cortex using Fluorescence-Activated Nuclei Sorting. Mussa Z, Tome-Garcia J, Jiang Y, Akbarian S, Tsankova NM J. Vis. Exp.(170), e62405, doi:10.3791/62405(2021).

* Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience Clare Bryce, Zachary Grimes, Elisabet Pujadas, …, Carlos Cordon-Cardo & Mary E. Fowkes Modern Pathology (2021)

2020

* Umphlett M, Shea S, Tome-Garcia J, Zhang Y, Hormigo A, Fowkes M, Tsankova NM, Yong RL. Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report. BMC Cancer. 2020 Jan 20;20(1):47.

Espeso-Gil S, Halene T, Bendl J, Kassim B, Ben Hutta G, Iskhakova M, Shokrian N, Auluck P, Javidfar B, Rajarajan P, Chandrasekaran S, Peter CJ, Cote A, Birnbaum R, Liao W, Borrman T, Wiseman J, Bell A, Bannon MJ, Roussos P, Crary JF, Weng Z, Marenco S, Lipska B, Tsankova NM, Huckins L, Jiang Y, Akbarian S. A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. Genome Med. 2020 Feb 19;12(1):19.

Bozec D, Sattiraju A, Bouras A, Jesu Raj JG, Rivera D, Huang Y, Junqueira Alves C, Tejero R, Tsankova NM, Zou H, Hadjipanayis C, Friedel RH. Akaluc bioluminescence offers superior sensitivity to track in vivo glioma expansion. Neurooncol Adv. 2020 Oct 10;2(1):vdaa134.

2019

Flaherty E, Zhu S, Barretto N, Cheng E, Deans PJM, Fernando MB, Schrode N, Francoeur N, Antoine A, Alganem K, Halpern M, Deikus G, Shah H, Fitzgerald M, Ladran I, Gochman P, Rapoport J, Tsankova NM, McCullumsmith R, Hoffman GE, Sebra R, Fang G, Brennand KJ. Neuronal impact of patient-specific aberrant NRXN1α splicing. Nature Genetics. 2019 Dec;51(12):1679-1690.

Tejero R, Huang Y, Katsyv I, Kluge M, Lin JY, Tome-Garcia J, Daviaud N, Wang Y, Zhang B, Tsankova NM, Friedel CC, Zou H, Friedel RH. Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment. EBioMedicine. 2019 Apr;42:252-269.

2018

* Tome-Garcia J., P. Erfani, G. Nudelman, A. Tsankov, I. Koslyv, R. Tejero, B. Zhang, R. Friedel, W. Walsh, E. Zaslavsky, N.M. Tsankova. Analysis of Chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma, Nature Communications, 2018

* M.L. Miller, J. Tome-Garcia, A. Waluszko, T. Sidorenko, D.Y. Zhang, F. Yei, N.M. Tsankova. Practical bioinformatic DNA-sequencing pipeline for detecting oncogene amplification and EGFRvIII mutational status in clinical glioblastoma samples, JMD, 2019

Ruf-Zamojski F, Ge Y, Nair V, Zamojski M, Pincas H, Toufaily C, Tome-Garcia J, Stoeckius M, Stephenson W, Smith GR, Bernard DJ, Tsankova NM, Hartmann BM, Fribourg M, Smibert P, Swerdlow H, Turgeon JL, Sealfon SC. Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity. Nucleic Acids Res. 2018 Oct 24.

Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3): 485-488.

I Chen, N. Swinburne, N.M. Tsankova, M. Hefti, A. Aggarwal, A. Doshi, B. Delman, K. Nael. Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low Grade Glioma, Radiology, 2018

2017

* Tome-Garcia J., Tejero R., Nudelman G., ., Sebra R., Walsh M., Zaslasvky E., Friedel R., Doetsch F., Tsankova N.M. Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties. Stem Cell Reports, 8 (2017).

* Tome-Garcia J., F. Doetsch, N. M. Tsankova. FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand, Bio-protocol, 2017 Dec; 27(24).

2015-2016

* Darbinyan, A., E. O. Major, S. Morgello, S. Holland, C. Ryschkewitsch, M. C. Monaco, T. P. Naidich, J. Bederson, J. Malaczynska, F. Ye, R. Gordon, C. Cunningham-Rundles, M. Fowkes and N. M. Tsankova. “Bk Virus Encephalopathy and Sclerosing Vasculopathy in a Patient with Hypohidrotic Ectodermal Dysplasia and Immunodeficiency.” Acta Neuropathol Commun 4, no. 1 (2016): 73.

* Erfani P., Tome-Garcia J., Canoll P., Doetsch F., Tsankova N.M.  EGFR Promoter Exhibits Dynamic Histone Modifications and Binding of ASH2L and P300 in Human Germinal Matrix and Gliomas. Epigenetics, 10 (2015), 496-507.

Tsankov A.M., V. Akopian, R. Pop, C. Gifford C, N.M. Tsankova, A. Meissner, Rapid and quantitative assessment of human pluripotent cell differentiation potential. Nature Biotechnology, 2015.      

* R. Yong and N.M. Tsankova. Emerging Interplay of Genetics and Epigenetics in Gliomas – A New Hope for Targeted Therapy, Semin Pediatr Neurol, 22 (2015), 14-22.

H. Zou, R. Feng, Y. Huang, J. Tripodi, V. Najfeld, N.M. Tsankova, M. Jahashahi, L. Olson, P. Soriano, and R. Friedel, Double minute amplification of mutant PDGF receptor α in a mouse glioma model, Scientific Reports, 5 (2015), 8468.

* Odia Y., H. Varma, and N.M. Tsankova. Biphasic IDH1 Phenotype in a Diffusely Infiltrating Glioma: Implications for Pathogenesis, Treatment and Prognosis, Clinical Neuropathology (2015) Apr 24.

2014

A. Sosunov, X. Wu, N.M. Tsankova, E. Guilfoyle, G. McKhann, 2nd, and J. Goldman ‘Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain’, J Neurosci, 34 (2014), 2285-98.

* N.M. Tsankova and P. Canoll. Advances in genetic and epigenetic analyses of gliomas: a neuropathological perspective, Journal of Neurooncology, 119 (2014), 481-90.

A. Mitchell, P. Roussos, C. Peter, N. Tsankova, Akbarian S. The future of neuroepigenetics in the human brain. Prog Mol Biol Transl Sci, 128 (2014), 199-228.

2000-2013

* N.M. Tsankova, A. Kumar, and E. J. Nestler, ‘Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures’, J Neurosci, 24 (2004), 5603-10. (418 citations)

* N.M. Tsankova, O. Berton, W. Renthal, A. Kumar, R. L. Neve, and E. J. Nestler, ‘Sustained Hippocampal Chromatin Regulation in a Mouse Model of Depression and Antidepressant Action’, Nat Neurosci, 9 (2006), 519-25. (1503 citations)

* N. Tsankova, W. Renthal, A. Kumar, and E. J. Nestler, ‘Epigenetic Regulation in Psychiatric Disorders’, Nat Rev Neurosci, 8 (2007), 355-67. (1314 citations)

O. Berton, C. A. McClung, R. J. Dileone, V. Krishnan, W. Renthal, S. J. Russo, D. Graham, N.M. Tsankova, C. A. Bolanos, M. Rios, L. M. Monteggia, D. W. Self, and E. J. Nestler, ‘Essential Role of Bdnf in the Mesolimbic Dopamine Pathway in Social Defeat Stress’, Science, 311 (2006), 864-8. (1488 citations)

A. Kumar, K. H. Choi, W. Renthal, N.M. Tsankova, D. E. Theobald, H. T. Truong, S. J. Russo, Q. Laplant, T. S. Sasaki, K. N. Whistler, R. L. Neve, D. W. Self, and E. J. Nestler, ‘Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum’, Neuron, 48 (2005), 303-14. (680 citations)

W. Renthal, I. Maze, V. Krishnan, H. E. Covington, 3rd, G. Xiao, A. Kumar, S. J. Russo, A.  Graham, N. Tsankova, T. E. Kippin, K. A. Kerstetter, R. L. Neve, S. J. Haggarty, T. A. McKinsey, R. Bassel-Duby, E. N. Olson, and E. J. Nestler, ‘Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli’, Neuron, 56 (2007), 517-29. (504 citations)

O. Berton, H. E. Covington, 3rd, K. Ebner, N.M. Tsankova, T. L. Carle, P. Ulery, A. Bhonsle, M. Barrot, V. Krishnan, G. M. Singewald, N. Singewald, S. Birnbaum, R. L. Neve, and E. J. Nestler, ‘Induction of Deltafosb in the Periaqueductal Gray by Stress Promotes Active Coping Responses’, Neuron, 55 (2007), 289-300.

* N.M. Tsankova, C. Bevan, V. Jobanputra, Y. C. Ko, E. W. Mayer, J. H. Lefkowitch, M. Mansukhani, L. P. Rowland, G. Bhagat, and K. Tanji, ‘Peripheral T-Cell Lymphoma Emerging In a Patient with Aggressive Polymyositis: Molecular Evidence for Neoplastic Transformation of an Oligoclonal T-Cell Infiltrate’, Acta Neuropathol (2013), 126(4):595-601.

J. A. Ellis, N.M. Tsankova, R. D’Amico, J. C. Ausiello, P. Canoll, M. K. Rosenblum, and J.N. Bruce, ‘Epithelioid Pituicytoma’, World Neurosurg, 78 (2012), 191 E1-7.

K. E. Remy, R. W. Elder, N.M. Tsankova, and R. M. Conroy, ‘Cerebellar Metastatic Papillary Thyroid Carcinoma in a Pediatric Patient with Complex Congenital Heart Disease’, J Pediatr Endocrinol Metab, 25 (2012), 1195-9.