Gardner TJ, Cohen T, Redmann V, Lau Z, Felsenfeld D, Tortorella D. Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle. Antiviral Res. 2015 Jan;113:49-61. PMCID: PMC4324837. http://www.ncbi.nlm.nih.gov/pubmed/25446405

Noriega VM, Haye KK, Kraus TA, Kowalsky SR, Ge Y, Moran TM, Tortorella D. Human cytomegalovirus modulates monocyte-mediated innate immune responses during  short-term experimental latency in vitro. J Virol. 2014 Aug;88(16):9391-405. doi: 10.1128/JVI.00934-14. PMCID: PMC4136239. http://www.ncbi.nlm.nih.gov/pubmed/24920803

Noriega VM, Gardner TJ, Redmann V, Bongers G, Lira SA, Tortorella D. Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination. Viruses. 2014  Mar 12;6(3):1202-18. PMCID: PMC3970146. http://www.ncbi.nlm.nih.gov/pubmed/24625810

Redmann V, Gardner T, Lau Z, Morohashi K, Felsenfeld D, Tortorella D. Novel class of potential therapeutics that target ricin retrograde translocation. Toxins (Basel). 2013 Dec 23;6(1):33-53.l PMCID: PMC3920248. http://www.ncbi.nlm.nih.gov/pubmed/24366208

Miller MS, Gardner TJ, Krammer F, Aguado LC, Tortorella D, Basler CF, Palese P. Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med. 2013 Aug 14;5(198):198ra107. PMCID: PMC4091683. http://www.ncbi.nlm.nih.gov/pubmed/23946196

Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran  T, Britt W, Weinberger LS, Tortorella D. Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies. Clin Vaccine Immunol. 2013 Apr;20(4):540-50. PMCID: PMC3623408. http://www.ncbi.nlm.nih.gov/pubmed/23389931

Noriega V, Redmann V, Gardner T, Tortorella D. Diverse immune evasion strategies by human cytomegalovirus. Immunol Res. 2012 Dec;54(1-3):140-51. PubMed PMID: 22454101. http://www.ncbi.nlm.nih.gov/pubmed/22454101

Noriega VM, Hesse J, Gardner TJ, Besold K, Plachter B, Tortorella D. Human cytomegalovirus US3 modulates destruction of MHC class I molecules. Mol Immunol.  2012 Jun;51(2):245-53. PMCID: PMC3367378. http://www.ncbi.nlm.nih.gov/pubmed/22497807

Redmann V, Oresic K, Tortorella LL, Cook JP, Lord M, Tortorella D. Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors. J Biol Chem. 2011 Jun 17;286(24):21231-8. PMCID: PMC3122183. http://www.ncbi.nlm.nih.gov/pubmed/21527639

Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, Tortorella D, Smit MJ, Lira SA. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in  transgenic mice. J Clin Invest. 2010 Nov;120(11):3969-78. PMCID: PMC2964974. http://www.ncbi.nlm.nih.gov/pubmed/20978345

Ng CL, Oresic K, Tortorella D. TRAM1 is involved in disposal of ER membrane degradation substrates. Exp Cell Res. 2010 Aug 1;316(13):2113-22. PMCID: PMC2900547. http://www.ncbi.nlm.nih.gov/pubmed/20430023

Oresic K, Mueller B, Tortorella D.Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep. 2009 Jun;29(3):173-81. PMCID: PMC2674128. http://www.ncbi.nlm.nih.gov/pubmed/18811591

Oresic K, Ng CL, Tortorella D. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2009 Feb 27;284(9):5905-14. PMCID: PMC2645836. http://www.ncbi.nlm.nih.gov/pubmed/19121997

Noriega VM, Tortorella D. Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules. J Virol. 2009 Feb;83(3):1359-67. PMCID: PMC2620908. http://www.ncbi.nlm.nih.gov/pubmed/19004944

Oresic K, Tortorella D. Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules. J Gen Virol. 2008 May;89(Pt 5):1122-30. PMCID: PMC2634742. http://www.ncbi.nlm.nih.gov/pubmed/18420789

Noriega VM, Tortorella D. A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2008 Feb 15;283(7):4031-43. PMCID: PMC2613023. http://www.ncbi.nlm.nih.gov/pubmed/18086679

Baker BM, Tortorella D. Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides. J Biol Chem. 2007 Sep 14;282(37):26845-56. PubMed PMID: 17650499. http://www.ncbi.nlm.nih.gov/pubmed/17650499

Oresic K, Noriega V, Andrews L, Tortorella D. A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules. J Biol Chem. 2006 Jul 14;281(28):19395-406. PubMed PMID: 16687410. http://www.ncbi.nlm.nih.gov/pubmed/16687410

Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal  peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 2006 Jun 15;441(7095):894-7. PubMed PMID: 16738546. http://www.ncbi.nlm.nih.gov/pubmed/16738546

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17;201(2):267-77. PMCID: PMC2212795. http://www.ncbi.nlm.nih.gov/pubmed/15642744

Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection  of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.
Mol Biol Cell. 2004 Apr;15(4):1635-46. PMCID: PMC379262.

Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL. A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J. 2004 Feb 11;23(3):650-8. PMCID: PMC1271816. http://www.ncbi.nlm.nih.gov/pubmed/14749736

Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12;278(37):34804-11. PubMed PMID: 12832421. http://www.ncbi.nlm.nih.gov/pubmed/12832421

Lilley BN, Tortorella D, Ploegh HL. Dislocation of a type I membrane protein  requires interactions between membrane-spanning segments within the lipid bilayer. Mol Biol Cell. 2003 Sep;14(9):3690-8. Epub 2003 Jun 13. PubMed PMID: 12972557; PubMed Central PMCID: PMC196560. http://www.ncbi.nlm.nih.gov/pubmed/12972557

Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003  Feb 28;278(9):6664-72. Epub 2002 Dec 12. PubMed PMID: 12482753. http://www.ncbi.nlm.nih.gov/pubmed/12482753

Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov;76(22):11753-6. PMCID: PMC136774. http://www.ncbi.nlm.nih.gov/pubmed/12388737

Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE. Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol. 2002 May;76(10):5043-50. PMCID: PMC136120. http://www.ncbi.nlm.nih.gov/pubmed/11967320

Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J Biol Chem. 2002 Mar 29;277(13):11306-13. PubMed PMID: 11790769. http://www.ncbi.nlm.nih.gov/pubmed/11790769

Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 1;21(5):1041-53. PMCID: PMC125905. http://www.ncbi.nlm.nih.gov/pubmed/11867532

Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 1;277(5):3258-67. PubMed PMID: 11717308. http://www.ncbi.nlm.nih.gov/pubmed/11717308

Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001 Sep;8(9):913-29. PubMed PMID: 11564559. http://www.ncbi.nlm.nih.gov/pubmed/11564559

Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Curr Opin Immunol. 2001 Aug;13(4):442-50. PubMed PMID: 11498300. http://www.ncbi.nlm.nih.gov/pubmed/11498300

Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound  to the class I molecule HLA-A2. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6794-9. PMCID: PMC34432. http://www.ncbi.nlm.nih.gov/pubmed/11391001

Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. J Virol. 2001 Jun;75(11):5197-204. PMCID: PMC114925. http://www.ncbi.nlm.nih.gov/pubmed/11333901

Rehm A, Stern P, Ploegh HL, Tortorella D. Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J. 2001 Apr 2;20(7):1573-82. PMCID: PMC145509. http://www.ncbi.nlm.nih.gov/pubmed/11285222

Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H. Down-regulation of MHC  class I antigen presentation by HCMV; lessons for tumor immunology. Immunol Invest. 2000 May;29(2):97-100. PubMed PMID: 10854174.

Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000;18:861-926. PubMed PMID: 10837078. http://www.ncbi.nlm.nih.gov/pubmed/10837078

Schust DJ, Tortorella D, Ploegh HL. Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. J Reprod Immunol.  1999 Jul;43(2):243-51. PubMed PMID: 10479060. http://www.ncbi.nlm.nih.gov/pubmed/10479060

Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol. 1999 Feb;9(1):37-46. PubMed PMID: 10092549. http://www.ncbi.nlm.nih.gov/pubmed/10092549

Schust DJ, Tortorella D, Seebach J, Phan C, Ploegh HL. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J Exp Med. 1998 Aug 3;188(3):497-503. PMCID: PMC2212475. http://www.ncbi.nlm.nih.gov/pubmed/9687527

Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, Ploegh HL. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol. 1998 Jul 27;142(2):365-76. Erratum in: J Cell Biol 1999 May 3;145(3). PMCID: PMC2133060. http://www.ncbi.nlm.nih.gov/pubmed/9679137

Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H.Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6629-34. PMCID: PMC21209. http://www.ncbi.nlm.nih.gov/pubmed/9192616

Wiertz E, Hill A, Tortorella D, Ploegh H. Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol Lett. 1997 Jun 1;57(1-3):213-6. PubMed PMID: 9232454.

Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 1996 Dec 5;384(6608):432-8. PMID: 8945469. http://www.ncbi.nlm.nih.gov/pubmed/9232454

Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes. J Biol Chem. 1995 Nov 17;270(46):27446-52. PubMed PMID: 7499201. http://www.ncbi.nlm.nih.gov/pubmed/7499201

Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis of the  structure of diphtheria toxin shows all three domains undergo structural changes  at low pH. J Biol Chem. 1995 Nov 17;270(46):27439-45. PubMed PMID: 7499200. http://www.ncbi.nlm.nih.gov/pubmed/7499200

Tortorella D, London E. Method for efficient pelleting of small unilamellar model membrane vesicles. Anal Biochem. 1994 Mar;217(2):176-80. PubMed PMID: 8203744. http://www.ncbi.nlm.nih.gov/pubmed/8203744

Tortorella D, Ulbrandt ND, London E. Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding. Biochemistry. 1993 Sep 7;32(35):9181-8. PubMed PMID: 8369285. http://www.ncbi.nlm.nih.gov/pubmed/8369285

London E, Ulbrandt ND, Tortorella D, Jiang JX, Abrams FS. Insights into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation. Soc Gen Physiol Ser. 1993;48:45-61. Review. PubMed PMID: 8503054. http://www.ncbi.nlm.nih.gov/pubmed/8503054