Teunissen lab publications

 

  1. van der Meel R, Hofstraat S, Anbergen S, Zwolsman R, Deckers J, van Elsas Y, Trines M, Versteeg I, Priem B, Darwish Y, Kleuskens T, Borges F, Maas R, Verhalle L, Tielemans W, Vader P, de Jong O, Teunissen AJP, Brechbühl E, Janssen H, Fransen M, de Dreu A, Schrijver D, Toner YC, Beldman T, Netea M, Mulder W, Kluza E. A nature-inspired nanodelivery platform for gene silencing in hematopoietic stem and progenitor cells. Preprint, 2024.
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  2. Xiang Y, Xu Jialu, McGovern BL, Ranzenigo A, Huang W, Sang Z, Shen J, Diaz-tapia R, Pham ND, Teunissen AJP, Rodriguez ML, Benjamin J, Taylor DJ, van Leent MMT, White KM, Garcia-Sastre A, Zhang P, Shi Y. Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy. Cell, 2024.
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  3. Jacobs MME, Maas RJF, Jonkman I, Negishi Y, Zamora WT, Yanginglar C, van Heck J, Matzaraki V, Martens JHA, Baltissen M, Vermeulen M, Morla-Folch J, Ranzenigo A, Wang W, Umali M, Ochando J, van der Vlag J, Hilbrands LB, Joosten LAB, Netea M, Mulder WJM, van Leent MMT, Mhlanga MM, Teunissen AJP, Rother N, Duivenvoorden R. Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling. Cell rep., 2024.
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  4. Jonkman I, Jacobs MME, Negishi Y, Yanginlar C, Martens JHA, Baltissen M, Vermeulen M, van den Hoogen MWF, Baas M, van der Vlag J, Fayad ZA, Teunissen AJP, Madsen JC, Ochando J, Joosten LAB, Netea M, Mulder WJM, Mhlanga MM, Hilbrands LB, Rother N, Duivenvoorden R. Trained immunity suppression determines kidney allograft survival. Am. J. Transplant, 2024.
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  5. Wauters AC*, Scheerstra JF*, van Leent MMT*, Teunissen AJP*, Priem B, Beldman TJ Rother N, Duivenvoorden R, Prévot G, Munitz J, Toner YC, Deckers J, van Elsas Y, Mora-Raimundo P, Chen G, Nauta SA, Verschuur AVD, Griffioen AW, Schrijver DP, Anbergen T, Li Y, Wu H, Mason AF, van Stevendaal MHME, Kluza E, Post RAJ, Joosten LAB, Netea MG, Calcagno C, Fayad ZA, van der Meel R, Schroeder A, Abdelmohsen LKEA, Mulder WJM, van Hest JCM, Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy, Nat. Nanotech., 2024.
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  6. Karekar N, Cahn AR, Morla-Folch J, SAffon A, Ward RW, Ananthanarayanan A, Teunissen AJP, Bhardwaj N, Vabret N, Protocol for the development of mRNA lipid nanoparticle vaccines and analysis of immunization efficiency in mice. STAR prot., 2024.
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  7. Toner YC, Prevot G, van Leent MMT, Munitz J, Oosterwijk R, Verschuur AVD, van Elsas Y, Peric V, Maas RJF, Ranzenigo A, Morla-Folch J, Wang W, Umali M, de Drue A, Chimene Fernandes J, Sullivan NAT, Maier A, Mason C, Reiner T, Fayad ZA, Mulder WJM, Teunissen AJP, Perez-Medina C. Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer. npj imaging, 2024.
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  8. Maier A, Teunissen AJP, Nauta SA, Lutgens E, Fayad ZA, van Leent MMT, Uncovering atherosclerotic cardiovascular disease by PET imaging. Nat. Rev. Cardiol. 2024.
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  9. Morla-Folch J, Ranzenigo A, Fayad ZA, Teunissen AJP. Nanotherapeutic heterogeneity: sources, effects, and solutions. Small, 2023.
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  10. Rother N, Yanginlar C, Prévot G, Jonkman I, 17 others, Mulder WJM, van der vlag J, Teunissen AJP, Duivenvoorden R., Acid ceramidase regulates innate immune memory. Cell rep., 2023.
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  11. Schrijver DP, Rorin RJ, Deckers J, 20 others, van Leent MMT, Teunissen AJP, van der Meel R, Fayad ZA, Joosten LAB, Fisher EA, Merkz M, Netea MG, Mulder MMT. Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells. Nat. Biomed. Eng., 2023.
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  12. Maier A, Toner AC, Munitz J, Sullivan NAT, Sakurai K, Meerwaldt AE, Brechbuhl EES, Prevot G, van Elsas Y, Maas RJF, Ranzenigo A, Soultanidis G, Rashidian M, Perez-Medina C, Heo GS, Gropler RJ, Liu Y, Reiner T, Nahrendorf M, Swirski FK, Strijkers GJ, Teunissen AJP, Calcagno C, Fayad ZA, Mulder WJM, van Leent MMT. Multiparametric immunoimaging maps inflammatory signatures in murine myocardial infarction models. JACC: Basic to Transl. Sci., 2023.
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  13. Meerwaldt AE, Straathof M, Oosterveld, W, van Heijningen CL, van Leent MMT, Toner AC, Munitz J, Teunissen AJP, Daemen CC, van der Toorn A, van Vliet G, van Tilborg GAF, De Feyter HM, de Graaf RA, Hol EM, Mulder WJM, Dijkhuizen RM. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue states – A pilot study combining PET and deuterium metabolic imaging. J. Cereb. Blood Flow Metab., 2022.
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  14. Miha, J. O, Patel PM, Teunissen AJP, Miller C, Costa T, Momodu M, Muldoon D, Dehnadi A, Hanekamp I, Pthula V, Sanchez-Tarjuelo R, Prevot G, Mulder WJM, Ochando J, Madsen JC. Using mTOR inhibitor nanoimmunotherapy to induce cardiac allograft tolerance in non-human primates. J. Heart. Lung Transplant. 2022.
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  15. Gera S, Kuo TC , Gumerova AA, Korkmaz F, Sant D, DeMambro V, Sudha K, Padilla A, Prevot G, Munitz J, Teunissen AJP, et al. FSH-blocking therapeutic for osteoporosis. eLife. 2022.
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  16. Teunissen AJP, Mulder WJM, Duivenvoorden R, Fayad ZA. Sphingolipid-loaded nanobiologics for immune regulation. US Patent application 63/326,191, 2022.
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  17. Schrijver DP, de Drue A, Hostraat, SRJ, Kluza A, Zwolsman R, Deckers J, Anbergen T, de Bruin K, Trines MM, Nugraha EG, Ummels F, Röring R, Beldman T, Teunissen AJP, Fayad ZA, van der Meel R, Mulder WJM. Nanoengineering apolipoprotein A1-based immunotherapeutics. Adv. Ther., 2021.
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  18. Teunissen AJP, Abousaway OB, Munitz J, van Leent MMT, Toner YC, Priem B, Senders ML, Pérez-Medina C, Mulder WJM, Rashidian M. Employing nanobodies for immune landscape profiling by PET imaging in mice. STAR Prot., 2021.
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  19. Teunissen AJP, Burnett EB, Prévot G, Klein ED, Bivona D, Mulder WJM., Embracing nanomaterials’ interaction with the innate immune system, WIREs Interdiscip. Rev. Nanomed. and Nanobiotechnol., 2021.
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  20. Teunissen AJP, van Leent MT, Geoffrey P, Brechbuhl EES, Perez-Medina C, Duivenvoorden R, Fayad ZA, Mulder WJM, Targeting trained innate immunity with nanobiologics to treat cardiovascular disease. Arterioscler. Thromb. Vasc. Biol., 2021.
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  21. van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, et al. Prosaposin mediates inflammation in atherosclerosis. Sci. Transl. Med., 2021.
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  22. van Leent MMT, Meerwaldt AE, Berchouchi A, Toner YC, Burnett ME, Klein ED et al. Teunissen AJP. A modular approach towards producing nanotherapeutics targeting the innate immune system. Sci. Adv., 2021.
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  23. Mulder WJM, Ochando J, Fayad ZA, Duivenvoorden R, Teunissen AJP, Perez-Medina C, Netea M, Joosten L, Nanobiologic compositions for inhibiting trained immunity., US Patent application 16863438, 2020.
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  24. Mulder WJM, Ochando J, Fayad ZA, Duivenvoorden R, Teunissen AJP, Perez-Medina C, Netea M, Joosten L, Methods for inhibiting trained immunity with nanobiologic compositions, US Patent application US20200376146A1, 2020.
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  25. Priem B, van Leent MMT, Teunissen AJP, Marios Sofias A, Mourits VP, Willemsen L, et al. Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition. Cell, 2020.
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  26. Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP et al. Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs. Circ. Cardiovasc. Imaging, 2020.
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  27. Pérez-Medina C, Teunissen AJP, Kluza E, Mulder WJM, van der Meel R. Nuclear imaging approaches facilitating nanomedicine translation. Adv. Drug. Deliver. Rev. 2020.
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  28. Sofias AM, Toner YC, Meerwaldt AE, van Leent MMT, Soultanidis G, Elschot M, Gonai H, Grendstad K, Flobak Å, Neckmann U, Wolowczyk C, Fisher L E, Reiner T, de Lange Davies C, Bjørkøy G, Teunissen AJP, et al. Tumor targeting by αvβ3-integrin-specific lipid nanoparticles occurs via phagocyte hitchhiking. ACS Nano, 2020.
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  29. Schoormans J, Calcagno C, Daal MR, Wüst R, Faries C, Maier A, Teunissen AJP, et al. An iterative sparse deconvolution method for multicolor F-MRI. Magn. Reson. Med., 2020.
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  30. Senders ML, Meerwaldt AE, van Leent MMT, 25 others, Teunissen AJP, Fayad AF, Calcagno C, Strijker GJ, Mulder WJM. Probing myeloid cell dynamics in ischemic heart disease by nanobiologic hotspot imaging. Nat. Nanotech. 2019.
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  31. Mulder WJM, Ochando J, Fayad ZA, Duivenvoorden R, Teunissen AJP, Perez-Medina C, Netea M, Joosten L, Inhibiting trained immunity with a therapeutic nanobiologic composition, US Patent WO/2019/100044, 2019.
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  32. Teunissen AJP, Paffen TFE, Filot IAW Filot, van der Haas RJC,
Lanting MD, de Greef, TFA, Meijer EW, Supramolecular interactions between catalytic species allow rational control over reaction kinetics. Chem. Sci., 2019.
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  33. Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, et al. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Sci. Transl. Med., 2019.
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  34. Teunissen AJP, Pérez-Medina C, Meijerink A, Mulder WJM, Investigating supramolecular systems using Förster resonance energy transfer. Chem. Soc. Rev., 47, 2018, 7027.
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  35. Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan, BL, Teunissen AJP et al. Efficacy and safety assessment of a TRAF6-targeted nano-immunotherapy in atherosclerotic mice and non-human primates. Nat. Biomed. Eng., 2, 2018, 279.
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  36. Vilanova N, de Feijter I, Teunissen AJP, Voets IK, Light Induced Assembly and Self-sorting of Supramolecular Colloids. Sci. Rep., 8, 2018, 1271.
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  37. Teunissen AJP, Berrocal JA., Meijer EW. Supramolecular Polymerization of a Ureidopyrimidinone Based [2]Catenane Prepared via Ring-Closing Metathesis. J. Pol. Sci. A. Pol. Chem., 55, 2017, 2971.
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  38. Paffen TFE, Teunissen AJP, de Greef TFA, Meijer EW. Improved Supramolecular Buffering by Multivalency and Model Driven Engineering. Proc. Natl. Acad. Sci., 114, 2017, 12882.
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  39. van der Weegen R, Teunissen AJP, Meijer EW. Directing the Self-Assembly Behaviour of Porphyrin-Based Supramolecular Systems. Chem. Eur. J., 23, 2017, 3499.
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  40. Teunissen AJP, Paffen TFE, Ercolani G, de Greef TFA, Meijer EW.
Regulating Competing Supramolecular Interactions Using Ligand Concentration. J. Am. Chem. Soc., 138, 2016, 6852.
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  41. Zha RH, de Waal BFM, Lutz M, Teunissen AJP, Meijer EW. End Groups of Functionalized Siloxane Oligomers Direct Block-Copolymeric or Liquid-Crystalline Self-Assembly Behavior. J. Am. Chem. Soc.,138, 2016, 5693.
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  42. Teunissen AJP, van der Haas RJC, Vekemans JAJM, Palmans ARA, Meijer EW. Scope and Limitations of Supramolecular Autoregulation. Bull. Chem. Soc. Jpn., 89, 2016, 308.
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  43. Teunissen, AJP, Nieuwenhuizen, MML, Rodríguez-Llansola F, Palmans ARA, Meijer E W. Mechanically Induced Gelation of a Kinetically Trapped Supramolecular Polymer. Macromolecules, 47, 2014, 8429.
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  44. Reijenga J, Hoof A van, van Loon A, Teunissen AJP, Development of Methods for the Determination of pKa Values. Anal. Chem. Insights, 8, 2013, 53.