Publications

  1. Rodriguez-Tirado C, Kale N, Carlini MJ, Shrivastava N, Alcina Rodrigues, Khalil B, Bravo-Cordero JJ, Yan Hong, Alexander M, Ji J, Fariba Behbod, and Sosa MS#. “NR2F1 is a barrier to dissemination of early stage breast cancer cells” DOI:10.1158/0008-5472.CAN-21-4145. Cancer Research, 2022. #corresponding author.
  2. Borriello L., Coste A., Traub B., Sharma V., Karagiannis G., Lin Y., Wang Y., Ye X., Duran C., Chen X., Friedman M., Sosa MS, Sun D., Dalla E., Singh D., Oktay M., Aguirre-Ghiso J., Condeelis J. and Entenberg D. “Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells”. Nature Communications, 2022.
  3. Khalil B, Sanchez R, Rhaman T, Moritsch S, Rodriguez Martinez A, Farias E, Cheung JF, Nobre AR, Kale N, Sosa MS# and Aguirre-Ghiso JA#. “A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy”. JEM, in press, 2021. doi: 10.1084/jem.20210836. # co-corresponding authors.
  4. Borgen E*, Rypdal MC*, Sosa MS*, Renolen A, Schlichting E, Lønning PE, Synnestvedt M, Aguirre-Ghiso JA, and Naume B. “NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients”. Breast Cancer Res. 2018 Oct 16;20(1):120. doi: 10.1186/s13058-018-1049-0. PubMed PMID: 30322396; PubMed Central PMCID: PMC6190561.
  5. Linde N, Casanova-Acebes M*, Sosa MS*, Mortha A, Rahman A, Farias EF, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, and Aguirre-Ghiso JA. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Communications. November 2017
  6. Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS, Aguirre-Ghiso JA, Condeelis J, Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics, Methods, Volume 128, 1 September 2017, Pages 65-77, ISSN 1046-2023, https://doi.org/10.1016/j.ymeth.2017.07.019
  7. Harper*, K, Sosa*# MS., Hedayatollah Hosseini, David Entenberg, Julie F. Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger J. Davis, Eduardo F. Farias, John Condeelis, Christoph Klein, and Julio A. Aguirre-Ghiso#, (2016). Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature. 2016 Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PubMed PMID: 27974798.  *=equal contributions, #=corresponding author. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000. https://f1000.com/prime/727099751; Highlighted in Nature Reviews  Cancer http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html. 3151814997 |www.sciencedaily.com/releases/2016/12/161214145615.htm.
  8. Hosseini, H., Obradović,M., Hoffmann, M., Harper, K, Sosa MS., Werner-Klein, M., Lahiri Nanduri, K., Werno, C., Ehrl C., Maneck, M., Patwary, N., Haunschild, G., Gužvić, M., Reimelt, C., Grauvogl, M., Eichner, N., Weber, F., Hartkopf, A., Taran, F-A., Brucker, S., Fehm, T., BrigitteRack, Buchholz, S., Spang, R., Meister, G., Aguirre-Ghiso, J., Klein, C. Early dissemination seeds metastasis in breast cancer. Nature. 2016 Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PubMed PMID: 27974799. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted in Nature Reviews  Cancer http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html
  9. Sosa MS#. “Dormancy Programs as emerging anti-metastasis therapeutic alternatives” DOI: 10.1080/23723556.2015.1029062. Molecular & cellular oncology. 2015; 3(1):e1029062.
  10. Sosa MS, Estrada Y, Parikh F, Bosch A, Zheng Y, Bragado P, Ekpin E, George A, Gaspar Maia A, Chung C, Bernstein E, Farias EF and Aguirre-Ghiso JA. “NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence and pluripotency programmes”. DOI:10.1038, Nature Communications, 2015.
  11. Sosa MS*#, Bragado P*#, Aguirre-Ghiso JA#. “Mechanisms of disseminated cancer cell dormancy: an awakening field”. Nature Rev. Cancer. 2014 Sep;14(9):611-22. This review was selected and edited as the journal cover topic.
  12. Linde N, Sosa MS, Aguirre-Ghiso JA. “Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression”. EMBO J. 2014 Aug 18;33(16):1737-9.
  13. Aguirre-Ghiso JA, Bragado P, Sosa MS. “Metastasis Awakening: Targeting dormant cancer”. Nat Med. 2013 Mar 6;19(3):276-7.
  14. Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CT, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T. “A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α”. EMBO Mol Med. 2013 Mar;5(3):366-83.
  15. Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, Sosa MS, Aguirre-Ghiso JA, Segall JE. “Dormancy signatures and metastasis in estrQQogen receptor positive and negative breast cancer”. PLoS One. 2012;7(4):e35569. Epub 2012 Apr 18.
  16. Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E, Aguirre-Ghiso JA. “Analysis of Marker-Defined HNSCC Subpopulations Reveals a Dynamic Regulation of Tumor Initiating Properties.” PLoS One (2012) ;7(1):e29974. Epub 2012 Jan 20.
  17. Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C,Sosa MS, Kazanietz MG. “Rac signaling in breast cancer: A tale of GEFs and GAPs.” Cell Signal. (2011), August 27.
  18. Sosa MS., Avivar-Valderas A, Bragado P., Wen HC., Aguirre-Ghiso JA. “ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease” Cancer Res., (2011) Sep 15;17(18):5850-7.
  19. Wen HC, Avivar-Valderas A, Sosa MS, Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA. “p38{alpha} Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.” Sci Signal., (2011), May 24;4(174):ra34.
  20. Sosa* MS., Lopez-Haber* C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. “Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.” Molecular Cell, (2010), Dec 22; 40(6):877-92. This article was selected for the cover of the journal, a highly prestigious honor. In addition it was highlighted in Nat. Rev. Cancer (McCarthy N, 2011) and Mol. Cell (Hynes NE and Gattelli, A, 2011).
  21. Griner, E. M., Caino, M.C., Sosa MS., Colon-Gonzalez, F., Chalmers, M., Mischak, H., Kazanietz, M.G. “A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation”. Biol Chem., (2010), May 28;285(22):16931-41.
  22. Sosa MS., Lewin, N., Sung-Hee, C., Blumberg, P., Kazanietz, M.G. “Biochemical characterization of hyperactive b2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains”. Biochemistry, (2009), Sep 1; 48(34):8171-8.
  23. Sosa* MS., Girotti*, M.R., Salvatierra, E., Prada, F., López de Olmo, J. A., Juárez Gallango, S., Albar, J.P., Podhajcer, O. L., Sabina Llera, A. “Proteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteine) activity in melanoma cells”. Proteomics, (2007), Nov; 7 (22):4123-34.

Book Chapters/Prefaces

  1. Sosa MS#. Chapter: “Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment”. Book: Cancer Metastasis through the Lymphovascular System, Springer Nature, 2021. In press.
  2. Sosa MS# and Bravo-Cordero#. “Understanding the Mechanistic Features of Cancer metastasis”. Cancer Reports, Wiley. https://doi.org/10.1002/cnr2.1238
  3. Maria Jose Carlini, Nitisha Shrivastava, and Maria Soledad Sosa#. Epigenetic and pluripotency aspects of disseminated cancer cells during minimal residual d Adv Exp Med Biol. 2018;1100:1-18. doi: 10.1007/978-3-319-97746-1_1. PubMed PMID: 30411257.
  4. Julio A. Aguirre-Ghiso and Maria Soledad Sosa. Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis. Annual Review of Cancer Biology. 2017.
  5. Maria Soledad Sosa, Emily Bernstein and Julio A. Aguirre-Ghiso Epigenetic regulation of cancer dormancy as a plasticity mechanism for metastasis initiation. Tumor Dormancy and Recurrence, Springer, 2017
  6. Maria Soledad Sosa, Paloma Bragado, Jayanta Debnath and Julio A. Aguirre-Ghiso. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy. Systems Biology of Tumor Dormancy. Editors, Enderling H, Almog N and Hlatky L. (2012) Springer Science + Business Media, INC. http://www.springerlink.com/content/u44l178561014r11/
  7. Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer (Eds: K. Pantel, C. Sotiriou, M. Ignatiadis). Recent Results Cancer Res. (2012);195:25-39.