Rogic A, Pant I, Grumolato L, Fernandez-Rodriguez R, Edwards A, Das S, Sun A, Yao S, Qiao R, Jaffer S, Sachidanandam R, Akturk G, Karlic R, Skobe M, Aaronson SA. High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer. Nat Commun. 2021 Nov 25;12(1):6889. doi: 10.1038/s41467-021-27108-8. PMID: 34824220; PMCID: PMC8617270.
Clement CC, D’Alessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, Mondanelli G, Ianni F, Gehrke S, Gargaro M, Manni G, Cara LCL, Runge P, Tsai WL, Karaman S, Arasa J, Fernandez-Rodriguez R, Beck A, Macchiarulo A, Gadina M, Halin C, Fallarino F, Skobe M, Veldhoen M, Moretti S, Formenti S, Demaria S, Soni RK, Galarini R, Sardella R, Lauvau G, Putterman C, Alitalo K, Grohmann U, Santambrogio L. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nat Commun. 2021 Jul 21;12(1):4447. doi: 10.1038/s41467-021-24785-3. PMID: 34290243; PMCID: PMC8295276.
Kulwatno J, Gearhart J, Gong X, Herzog N, Getzin M, Skobe M, Mills KL. Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint. Integr Biol (Camb). 2021 Feb 3;13(1):1-16. doi: 10.1093/intbio/zyaa024. PMID: 33443535.
Coste A, Karagiannis GS, Wang Y, Xue EA, Lin Y, Skobe M, Jones JG, Oktay MH, Condeelis JS, Entenberg D. Hematogenous Dissemination of Breast Cancer Cells From Lymph Nodes Is Mediated by Tumor MicroEnvironment of Metastasis Doorways. Front Oncol. 2020 Oct 26;10:571100. doi: 10.3389/fonc.2020.571100. PMID: 33194666; PMCID: PMC7649363.
Rogic A, Auger F, Skobe M. Isolation of Human Skin Lymphatic Endothelial Cells and 3D Reconstruction of the Lymphatic Vasculature In Vitro. Methods Mol Biol. 2018;1846:279-290. doi: 10.1007/978-1-4939-8712-2_18. PMID: 30242766.
Gibot L, Galbraith T, Bourland J, Rogic A, Skobe M, Auger FA. Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis. Nature Protocols 2017; 12:1077-1088. Article Link
Gibot L, Galbraith T, Kloos B, Das S, Lacroix DA, Auger FA, Skobe M. Cell-based approach for 3D reconstruction of lymphatic capillaries in vitro reveals distinct functions of HGF and VEGF-C in lymphangiogenesis. Biomaterials 2015; 129-39. Article Link
Serasinghe MN, Missert DJ, Asciolla JJ, Podgrabinska S, Wieder SY, Izadmehr S, Belbin G, Skobe M, Chipuk JE. Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance. Oncogene 2014; 1-11. Article Link
Zhao Y, van Rooy I, Hak S, Fay F, Tang J, Davies CL, Skobe M, Fisher EA, Radu A, Fayad ZA, de Mello DC, Meijerink A, Mulder WJ. Near-infrared fluorescence evergy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice. ACS Nano. 2013; 7:10362-70. Article Link
Das S, Sarrou E, Cassella M, Feirt N, Skobe M. Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J. Exp. Med. 2013; 210:1509-28. Article Link
Das S, Ladell DS, Podgrabinska S, Ponomarev V, Nagi C, Fallon JT, Skobe M. VEGF-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases. Cancer Res. 2010; 70:1814-24. Article Link
Lederle W, Linde N, Heusel J, Bzyl J, Woenne EC, Zwick S, Skobe M, Kiessling F, Fusenig NE, Mueller MM. Platelet-derived growth factor-B normalizes micromorphology and vessel Function in VEGF-A-induced squamous cell carcinomas. Am. J. Pathol. 2010; 176:981-94. Article Link
Podgrabinska S, Kamalu O, Mayer L, Shimaoka M, Randolph GJ, Skobe M. Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J. Immunol. 2009; 183:1767-79. Article Link
Shawber, CJ, Funahashi Y, Francisco E, Voronchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J. Clin. Inves. 2007; 117:3369-82. Article Link
Furtado GC, Marinkovic T, Martin AP, Garin A, Hoch B, Hubner W, Chen BK, Genden E, Skobe M, Lira SA. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc. Natl. Acad. Sci. USA. 2007; 104:5026-31. Article Link
Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM. Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am. J. Pathol. 2006; 169:1767-83. Article Link
Grossmann C, Podgrabinska S, SkobeM, Ganem D. Activation of NF-kappaB by the latent vFLIP gene of Kaposi’s sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype. J. Virol. 2006; 80:7179-85. Article Link
Roberts N, Kloos B, Cassella M, Podgrabinska S, PersaudK, WuY, Pytowski B, Skobe M. Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res. 2006; 66:2650-7. Article Link
Angeli V, Ginhoux F, Llodra J, Quemeneur L, Frenette PS, Skobe M, Jessberger R, Merad M, Randolph GJ. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 2006; 24:203-15. Article Link
Goldman J, Lee TX, Skobe M, Swartz M. Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin. Circ. Res. 2005; 96:1193-9. Article Link
Pytowski B, Goldman J, Persaud K, Wu Y, Witte L, Hicklin DJ, Skobe M, Boardman KC, Swartz M. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. JNCI 2005; 97:14-21. Article Link
Sugaya M, Watanabe T, Yang A, Starost MF, Kobayashi H, Atkins AM, Borris DL, Hanan EA, Schimel D, Bryant MA, Roberts N, Skobe M, Staskus KA, Kaldis P, Blauvelt A. Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Blood 2005; 105:2356-63. Article Link
Gruss CJ, Satyamoorthy K, Berking C, Lininger J, Nesbit M, Schaider H, Liu ZJ, Oka M, Hsu MY, Shirakawa T, Li G, Bogenrieder T, Carmeliet P, El-Deiry WS, Eck SL, Rao JS, Baker AH, Bennet JT, Crombleholme TM, Velazquez O, Karmacharya J, Margolis DJ, Wilson JM, Detmar M, Skobe M, Robbins PD, Buck C, Herlyn M. Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J. Invest. Dermatol. 2003; 120:683-92. Article Link
Podgrabinska S, Braun P, Velasco P, Kloos B, Pepper MS, Jackson DG Skobe M. Molecular characterization of lymphatic endothelial cells. Proc. Natl. Acad. Sci. USA 2002; 99:16069-16074. Article Link
Szuba A, Skobe M, Karkkainen MJ, Shin WS, Beyner DP, Rockson NB, Dakhil N, Spilman S, Goris ML, Strauss HW, Quartermous T, Alitalo K, Rockson S. Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J. 2002; 16:1985-7. Article Link
Hawighorst T, Skobe M, Streit M, Hong Y-K, Velasco P, Brown LF, Riccardi L, Lange-Asschenfeldt B, Detmar M. Activation of the Tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am. J. Pathol. 2002; 160:1381-92. Article Link
Skobe M, Hamberg L, Hawighorst T, Schirner M, Wolf GL, Alitalo K, Detmar M. Concurrent induction of lymphangiogenesis, angiogenesis and macrophage recruitment by VEGF-C in melanoma. Am. J. Pathol. 2001; 159:893-903. Article Link
Skobe M, Hawighorst T, Jackson D, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nature Med. 2001; 7:192-198. Article Link
Detmar M, Velasco P, Richard L, Claffey KP, Streit M, Riccardi L, Skobe M, Brown LF. Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas. Am. J. Pathol. 2000; 156:159-67. Article Link
Skobe M, Brown LF, Tognazzi K, Ganju RK, Dezube BJ, Alitalo K, Detmar M. Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi’s sarcoma. J. Invest. Dermatol. 1999; 113:1047-53. Article Link
Streit M, Velasco P, Brown LF, Skobe M, Richard L, Riccardi L, Lawler J, Detmar M. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am. J. Pathol. 1999; 155:441-52. Article Link
Bajou K, Noel A, Gerard RD, Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig NE, Carmeliet P, Collen D, Foidart JM. Absence of the host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nature Med. 1998; 4:923-928. Article Link
Skobe M, Fusenig NE. Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. Proc. Natl. Acad. Sci. USA 1998; 95:1050-1055. Article Link
Skobe M, Vosseler S, Rockwell P, Goldstein N, Fusenig NE. Halting angiogenesis suppresses carcinoma cell invasion. Nature Med. 1997; 3:1222-1227. Article Link
Other Peer Reviewed Publications and Invited Contributions
Podgrabinska S, Skobe M. Role of lymphatic vasculature in regional and distant metastases. Microvasc. Res. 2014; 95:46-52. Article Link
Skobe M. Lymphatic vessels and cancer. Lymphat. Res. Biol. 2012; 10:96. Editorial. Article Link
Skobe M, Dana R. Blocking the path of lymphatic vessels. Nature Med. 2009; 15:993-4. Commentary. Article Link
Das S, Skobe M. Lymphatic vessel activation in cancer. Ann. N. Y. Acad. Sci. 2008; 1131:235-41. Review. Article Link
Rafii S, Skobe M. Splitting vessels: Keeping lymph apart from blood. Nature Med. 2003; 9:166-8. Commentary. Article Link
Cassella M, Skobe M. Lymphatic vessel activation in cancer. Ann. N. Y. Acad. Sci. 2003; 979:120-130. Review. Article Link
Pepper MS, Tille J-C, Nisato R, Skobe M. Lymphangiogenesis and tumor metastasis. Cell Tissue Res. 2003; 314:167-177. Review. (special issue dedicated to vascular biology). Article Link
Pepper MS, Skobe M. Lymphatic endothelium: Morphological, molecular and functional properties. J. Cell Bio. 2003; 163:209-13. Review. Article Link
Swartz MA, Skobe M. Lymphatic function, lymphangiogenesis and cancer metastasis. Microscopy Res. 2001; 55:92-99. Review. Article Link
Skobe M, Detmar M. Structure, function, and molecular control of the skin lymphatic system. J. Invest. Dermatol. Symp. Proc. 2000; 14-19. Article Link
Book Chapters
Rogic A, Auger F, Skobe M. (2018) Isolation of human skin lymphatic endothelial cells and 3D reconstruction of the lymphatic vasculature in vitro. In: Lymphangiogenesis. Methods in Molecular Biology, vol 1846. Oliver G and Kahn M (Eds.), Humana press, New York, NY pp. 279-290. Book Chapter Link
Fusenig NE, Skobe M, Vosseler S, Hansen M, Lederle W, Airola K, Tomakidi P, Stark H-J, Boukamp P, Breitkreutz D. (2002) Tissue models to study tumor stroma interactions, In: Proteases and their inhibitors in cancer metastasis. Foidart J-M and Muschel RJ (Eds.), Kluwer Academic Publishers, Netherlands, pp. 205-223. Book Chapter Link
