An unprecedented amount of information has been gathered from the analysis of cancer genomes. However, our ability to use this information to identify mechanisms that are critical for cancer cells’ homeostasis and proliferation is still limited. Our lab has pioneered the integration of state-of-the-art genomics, functional studies, and systems biology methods to generate functional maps, allowing us to pinpoint key regulatory hubs that, when perturbed, compromise cancer cell viability. Thus, our research aims to use this data to elucidate novel mechanisms crucial to cancer cells’ survival that represent potential therapeutic opportunities.

The overall interest of our group is to understand the molecular mechanisms that regulate mammary gland development and breast cancer tumor progression with the ultimate goal of rationally developing effective and safe patient-oriented therapies.

The research projects in our laboratory are structured with three main objectives in mind:

  1. Identification of cancer-relevant functions
  2. In-depth mechanistic characterization of these functions
  3. Translation of these findings to the clinic