Publications

  • Chen TY, Gonzalez-Kozlova E, Soleymani T, La Salvia S, Kyprianou N, Sahoo S, Tewari AK, Cordon-Cardo C, Stolovitzky G, Dogra N. Extracellular vesicles carry distinct proteo-transcriptomic signatures that are different from their cancer cell of origin. iScience. 2022 May 18;25(6):104414. doi: 10.1016/j.isci.2022.104414. PMID: 35663013; PMCID: PMC9157216.
  • Salomon C, Das S, Erdbrügger U, Kalluri R, Kiang Lim S, Olefsky JM, Rice GE, Sahoo S, Andy Tao W, Vader P, Wang Q, Weaver AM. Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement. Endocr Rev. 2022 May 12;43(3):441-468. doi: 10.1210/endrev/bnac009. PMID: 35552682.
  • Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies – from exosomes to microvesicles. Cardiovasc Res. 2022 Mar 24:cvac031. doi: 10.1093/cvr/cvac031. Epub ahead of print. PMID: 35325061.
  • Lopez-Gordo E, Orlowski A, Wang A, Weinberg A, Sahoo S, Weber T. Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6. Front Med (Lausanne). 2021 Dec 21;8:732095. doi: 10.3389/fmed.2021.732095. PMID: 35036407; PMCID: PMC8757481.
  • Witwer KW, Goberdhan DC, O’Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, Ochiya T, Rome S, Sahoo S, Zheng L. Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles. J Extracell Vesicles. 2021 Dec;10(14):e12182. doi: 10.1002/jev2.12182. PMID: 34953156; PMCID: PMC8710080.
  • Sherman CD, Lodha S, Sahoo S. EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease. Cells. 2021 Jun 15;10(6):1500. doi: 10.3390/cells10061500. PMID: 34203713; PMCID: PMC8232200.
  • Bisserier M, Mathiyalagan P, Zhang S, Elmastour F, Dorfmüller P, Humbert M, David G, Tarzami S, Weber T, Perros F, Sassi Y, Sahoo S, Hadri L. Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension. Circulation. 2021 Jul 6;144(1):52-73. doi:10.1161/CIRCULATIONAHA.120.047978. Epub 2021 Jun 3. PMID: 34078089; PMCID: PMC8293289.
  • Magadum A, Singh N, Kurian AA, Sharkar MTK, Sultana N, Chepurko E, Kaur K, Żak MM, Hadas Y, Lebeche D, Sahoo S, Hajjar R, Zangi L. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Adv Sci (Weinh). 2021 Mar 12;8(10):2004661. doi: 10.1002/advs.202004661. PMID: 34026458; PMCID: PMC8132051.
  • Sahoo S, Adamiak M, Mathiyalagan P, Kenneweg F, Kafert-Kasting S, Thum T. Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases: Roadmap to the Clinic. Circulation. 2021 Apr 6;143(14):1426-1449. doi: 10.1161/CIRCULATIONAHA.120.049254. Epub 2021 Apr 5. PMID: 33819075; PMCID: PMC8021236.
  • Aday S, Hazan-Halevy I, Chamorro-Jorganes A, Anwar M, Goldsmith M, Beazley-Long N, Sahoo S, Dogra N, Sweaad W, Catapano F, Ozaki-Tan S, Angelini GD, Madeddu P, Benest AV, Peer D, Emanueli C. Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo. Mol Ther. 2021 Jul 7;29(7):2239-2252. doi: 10.1016/j.ymthe.2021.03.015. Epub 2021 Mar 18. PMID: 33744469; PMCID: PMC8261169.
  • Sahoo S, Kariya T, Ishikawa K. Targeted delivery of therapeutic agents to the heart [published online ahead of print, 2021 Jan 26]. Nat Rev Cardiol. 2021;10.1038/s41569-020-00499-9. doi:10.1038/s41569-020-00499-9
  • Sahoo S. METTL3-Regulated m6A Epitranscriptome Plasticity in Pathological Angiogenesis. Mol Ther. 2020 Oct 7;28(10):2105-2107. doi: 10.1016/j.ymthe.2020.09.018. Epub 2020 Sep 23. PMID: 32966773; PMCID: PMC7544999.
  • Oh JG, Lee P, Gordon RE, Sahoo S, Kho C, Jeong D. Analysis of extracellular vesicle miRNA profiles in heart failure. J Cell Mol Med. 2020 Jul;24(13):7214-7227. doi: 10.1111/jcmm.15251. Epub 2020 Jun 2. PMID: 32485073; PMCID: PMC7339231.
  • de Abreu RC, Fernandes H, da Costa Martins PA, Sahoo S, Emanueli C, Ferreira L. Native and bioengineered extracellular vesicles for cardiovascular therapeutics. Nat Rev Cardiol. 2020 Nov;17(11):685-697. doi: 10.1038/s41569-020-0389-5. Epub 2020 Jun 1. PMID: 32483304.
  • Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Gardiner C, Lötvall J, Sahoo S, Witwer KW. Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey. J Extracell Vesicles. 2018 Oct 24;7(1):1535745. doi: 10.1080/20013078.2018.1535745. PMID: 30370018; PMCID: PMC6201809.
  • Oh JG, Watanabe S, Lee A, Gorski PA, Lee P, Jeong D, Liang L, Liang Y, Baccarini A, Sahoo S, Brown BD, Hajjar RJ, Kho C. miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy. Circ Res. 2018 Aug 31;123(6):673-685. doi: 10.1161/CIRCRESAHA.118.312751. PMID: 30355233; PMCID: PMC6205728.
  • Mathiyalagan, P., M. Adamiak, J. Mayourian, Y. Sassi, Y. Liang, N. Agarwal, D. Jha, S. Zhang, E. Kohlbrenner, E. Chepurko, J. Chen, M.G. Trivieri, R. Singh, R. Bouchareb, K. Fish, K. Ishikawa, D. Lebeche, R.J. Hajjar, and S. Sahoo. FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair.Circulation, CIRCULATIONAHA.118.033794.
  • Adamiak, M., and S. Sahoo. 2018. Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics. Mol Ther, 26: 1635-1643.
  • Mathiyalagan P, Liang Y, Kim D, Misener S, Thorne T, Kamide C, et al. Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb. Circ Res. 2017 Apr 28;120(9):1466-1476; PMID:28298297
  • Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, Maji S, Monteleone F, Øverbye A, Panaretakis T, Patel T, Peinado H, Pluchino S, Principe S, Ronquist G, Royo F, Sahoo S, Spinelli C, Stensballe A, Théry C, van Herwijnen MJC, Wauben M, Welton JL, Zhao K, Mathivanan S. A novel community driven software for functional enrichment analysis of extracellular vesicles data. J Extracell Vesicles. 2017 May 26;6(1):1321455; PMID:28717418
  • Mayourian J, Cashman TJ, Ceholski DK, Johnson BV, Sachs D, Kaji DA, Sahoo S, Hare JM, Hajjar RJ, Sobie EA, Costa KD. Experimental and Computational Insight into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity. Circ Res. 2017 Jun 22. pii: CIRCRESAHA.117.310796; PMID:28642329
  • Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R. Methodological Guidelines to Study Extracellular Vesicles. Circ Res. 2017 May 12;120(10):1632-1648. Review; PMID: 28495994
  • Van Deun, …. Sahoo S, …Hendrix A. et al, 2017, EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods, 2017 Feb28 14(3) 228-232; PMID: 28245209
  • Sahoo S, Mathyalagan P, Hajjar R. 2017. Pericardial Fluid Exosomes – A New Material to Treat Cardiovascular Disease. Mol Ther. 2017 Mar 1;25(3):568-569; PMID: 28215995
  • Sahoo S, 2017. Cell-free Exosomes in clinics and in preclinical research; Circ Res, Invited Viewpoint Essay, 2017.
  • Agarwal U, George A, Bhutani S, Ghosh-Choudhary S, Maxwell JT, Brown ME, Mehta Y, Platt MO, Liang Y, Sahoo S, Davis ME. 2016. Experimental, Systems and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes From Pediatric Patients. Circ Res. 2017 Feb 17;120(4):701-712; PMID: 27872050
  • Mathiyalagan P, Sahoo S. Exosomes-Based Gene Therapy for MicroRNA Delivery.2016; Methods Mol Biol.2017;1521:139-152; PMID: 27910046
  • Sahoo S, Emanueli C. Exosomes in Diabetic Cardiomyopathy: The Next-Generation Therapeutic Targets?  Diabetes. 2016 Oct;65(10):2829-31; PMID: 27659226
  • Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J, Boruczkowski D, Madeja Z, Dawn B and Zuba-Surma EK. Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Stem Cells. 2015;33:2748-61.
  • Liang Y and Sahoo S, 2015. Exosomes explosion for cardiac resuscitation; J Am Coll Cardiol. 2015 Aug 11;66(6):612-5; PMID: 26248986
  • Emanueli C, Shearn AIU, Angelini GD, Sahoo S. Exosomes and exosomal miRNAs in  cardiovascular protection and repair; Vascul. Pharmacol., 2015 August, 71:24-30;PMID: 25869502
  • Kim DK, Lee J, Kim SR et al., 2014. EVpedia: A Community Web Portal for Extracellular Vesicles Research. Bioinformatics, 2015 Mar 15;31(6):933-9; PMID 25388151
  • Sahoo S, Losordo DW, 2014. Exosomes and cardiac repair after myocardial infarction. Emerging Science Review Series on ‘Exosomes in Cardiovascular Disease’, Circ Res, 2014 Jan 17;114(2):333-44; PMID: 24436429
  • Lotvall et al, 2014. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles, 2014 Dec 22;3:26913; PMID: 25536934
  • Mackie AR., Klyachko E., Thorne T, Kamide C, Schultz, KM., Millay M., Ito A., Liu T., Misener S., Sahoo S., Kishore R, Losordo DW.  Sonic hedgehog modified human CD34+ cells preserves cardiac function after acute myocardial infarction. 2012. Circ Res, Jul 20;111(3):312-21; PMID: 22581926
  • Sahoo S, Kurre P, 2012. Tumor Exosomes Promote Metastatic Dissemination by Reprogramming Bone Marrow Cells (Invited Review), Vesicles in Hematopoiesis, Cancer and Therapy. Hematologist-9, Sep1, 2012, ASH Journal.
  • Gauthier SA, Tizon B, Sahoo S, Levy E, 2012. In vitro assays measuring protection by proteins such as cystatin C of primary cortical neuronal and smooth muscle cells. Methods Mol Biol. 2012;849:275-87; PMID: 22528097
  • Gauthier SA, Sahoo S, Jung SS, Levy E. 2012. Murine cerebrovascular cells as a cell culture model for cerebral amyloid angiopathy: isolation of smooth muscle and endothelial cells from mouse brain. Methods Mol Biol.2012;849:261-74; PMID: 22528096
  • Sahoo S, Klyachko E, Thorne T, Misener S, Schultz KM, Millay M, Liu T, Ito A, Kamide C, Qin G, Kishore R, Losordo DW, 2011. Exosomes from human CD34+ stem cells mediate their of proangiogenic paracrine Activity, Circ Res, 109(7):724-8; PMID: 21835908
  • Tizon B, Sahoo S et.al., 2010. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One. 2010 Mar 23; 5(3):e9819; PMID: 20352108
  • Sahoo S, Suraishkumar GK, and Rao KK 2006. Reactive oxygen species induced by shear stress mediates cell death in Bacillus subtilis. Biotechnol. Bioeng. 2006 May 5;94: 118-127; PMID: 16570320
  • Sahoo S, Rao KK, Suresh AK, and Suraishkumar GK 2004. Reactive oxygen species mediated suppression of sporulation in Bacillus subtilis. Biotechnol. Bioeng. 2004 Jul 5;87(1): 81-89; PMID: 15211491
  • Sahoo S, Verma RK, Suresh AK, Bellare J, and Suraishkumar GK 2003. Macro-level and genetic-level responses of Bacillus subtilis. Biotechnol. Prog. 2003 Nov-Dec;19(6):1689-1696; PMID: 14656143
  • Sahoo S, Rao KK, and Suraishkumar GK 2003. Induced reactive oxygen species improve enzyme production from Aspergillus niger cultivation. Biotechnol. Lett. 2003 May;25: 821–825; PMID: 12882014
  • Nayak NR, Sahoo S, et al. 2002. Establishment of thin cross section (TCS) culture method for rapid micropropagation of Cymbidium aloifolium and Dendrobium nobile. Scientia Hort. 94: 107–116.
  • Rawool SB, Sahoo S, Rao KK, and Suraishkumar GK 2001. Improvement in enzyme productivities from mold cultivations using the liquid-phase oxygen supply strategy. Biotechnol. Prog. 2001 Sep-Oct; 17 (5), 832; PMID: 11587571

Patents (pending): Sahoo S, Losordo DW, Zembower D, Therapeutic exosomes derived from adult stem cells (2010) Serial no : 13/276,142 (NU2010-082 (WS IP# 2010-082-02)