Publications

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Selected Publications:

2014

Cook J.R., Carta L., Benard L., Chemaly E.R., Chiu E., Rao S.K., Hampton T.G., Yurchenco P., Costa K.D., Hajjar R.J., Ramirez F. (2014) Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J. Clin. Invest. 124:1329-1339.

 

2015

Cook J.R., Clayton N.P., Carta L., Galatioto J., Chiu E., Smaldone S., Nelson C.A., Cheng S.H., Wentworth B.M., Ramirez F. (2015) Dimorphic effects of TGFb signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome. Arterioscler Thromb Vasc. Biol. 35:911-917.

Zilberberg L., Phoon C.K.L., Robertson I., Dabovic B., Ramirez F., Rifkin D.B. (2015) Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome. Proc. Natl. Acad. Sci. USA 112:14012-14017.

 

2016

Lee J.J., Galatioto J., Rao S., Ramirez F., Costa K.D. (2016) Losartan attenuates degradation of aorta and lung tissue micromechanics in a mouse model of severe Marfan syndrome.  Ann Biomed Eng. 44:2994-3006.

 

2018

Galatioto J., Caescu C.I., Hansen J. , Cook J., Miramontes I., Iyengar R. and Ramirez F. (2018) Cell type-specific contributions of the Ang II type 1a receptor to aorta homeostasis and aneurysmal disease. Arterioscler Thromb Vasc. Biol  38:588-591.

Cikach F.S., Koch C.D., Mead T., Galatioto J., WIllared B., Emerton K., Eagleton M., Blackstone E, Ramirez F, Roselli EE, Apte S. (2018) Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.  J Clin Invest Insight 3(5) e97167.

 

2019

Hansen J., Galatioto J., Caescu C.I., Arnaud P., Calizo R.C., Spronck B., Murtada S.-I., Borkar R, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, HumphreyJD, Jondeau G., Boileau C., Ramirez F., Iyengar R. (2019) Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. JCI Insight  4:e127652.

 

2021

Caescu C.I., Hansen J., Crockett B., Xiao W.,  Arnaud P., Spronck B., Weinberg A., Hashimoto T., Murtada S.-I., Borkar R.,  Gallo J.M., Jondeau, G.,  Catherine Boileau C., Humphrey J.D., He J.C., Iyengar R., Ramirez F. (2021) Inhibition of homeodomain-interacting protein kinase 2 (HIPK2) alleviates thoracic aortic disease in mice with progressively severe Marfan syndrome. Arterioscler. Thromb Vasc. Biol. Epub adhead of print July 29