Publications | Peter Laboratory

Selected from over 100 peer-reviewed publications

Obesity, diabetes, and cardiovascular disease

Ellis KL, Zhou Y, Rodriguez-Murillo L, Beshansky JR, Ainehsazan E, Selker HP, Huggins GS, Cupples LA, Peter I. Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial. Pharmacogenomics J. Jan;17(1):76-83. PMID: 26644202

Udler, M.S., Nadkarni, G.N., Belbin, G., Lotay, V., Wyatt, C., Gottesman, O., Bottinger, E.P., Kenny, E.E. and Peter, I.Effect of Genetic African Ancestry on eGFR and Kidney Disease. J Am Soc Nephrol 2015 Jul;26(7):1682-92. PMID:25349204

Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Selker HP, Cupples LA, Huggins GS, Peter I. Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial. Pharmacogenomics J. 2015 Mar 17. doi: 10.1038/tpj.2015.10. [Epub ahead of print] PMID:25778467

Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Yang Y, Selker HP, Huggins GS, Cupples LA, Peter I. Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial. Pharmacogenomics J. 2015 Feb; 15(1):55-62. PMID:25135348

Peter I, Papandonatos GD, Belalcazar LM, Yang Y, Erar B, Jakicic JM, Unick JL, Balasubramanyam A, Lipkin EW, Delahanty LM, Wagenknecht LE, Wing RR, McCaffery JM, Huggins GS. Genetic Modifiers of Cardiorespiratory Fitness Response to Lifestyle Intervention. Med Sci Sports Exerc. 2014 Feb;46(2):302-11. PMID: 23899896

Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS, for the Genetics Subgroup of the Look AHEAD Study. Association of Type 2 Diabetes Susceptibility Loci with One-Year Weight 1 Loss in the Look AHEAD Clinical Trial. Obesity (Silver Spring), 2012 Aug;20(8):1675-82. PMID: 22307069

Saxena R, Elbers CC, Guo Y, Peter I, et al. Large-Scale Gene-Centric Meta-Analysis across 39 studies Identifies Type 2 Diabetes Loci. Am J Hum Genet, 2012 Mar 9;90(3):410-425. PMID: 22325160

Gottesman O, Drill E, Lotay V, Bottinger E, Peter I. Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk? PLoS One. 2012;7(9):e46419. PMID: 23029515

Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ; for the PROSPER Study Group. Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis. 2008 Sep;200(1):95-101. PMID:18262190

Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM. Variation in Estrogen-Related Genes Associated with Cardiovascular Phenotypes and Circulating Estradiol, Testosterone, and Dehydroepiandrosterone Sulfate Levels. J Clin Endocrinol Metab 2008 Jul;93(7):2779-85. PMID:18445666

Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples LA, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. Age-related Changes in Echocardiographic Measurements: Association with Variation in the Estrogen Receptor-α Gene. Hypertension; May;49(5):1000-6, 2007. PMID:17372038

Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME and Housman DE. Tobacco smoking, estrogen receptor a gene variation and small low density lipoprotein level. Hum Mol Genet, 14(16):2405-2413, 2005. PMID: 16014638

Shearman A, Cupples A, Demissie S, Peter I, Schmid C, Karas R, Mendelsohn M, Housman D, Levy D. Estrogen Receptor α Gene Variation is Associated with Susceptibility to Myocardial Infarction. JAMA; 290: 2263-2270, 2003. PMID:16484614

Craniosynostosis

Sewda A, White SR, Erazo M, Hao K, García-Fructuoso G, Fernández-Rodriguez I, Heuzé Y, Richtsmeier JT, Romitti PA, Reva B, Jabs EW, Peter I. (2019) Nonsyndromic craniosynostosis: novel coding variants. Pediatric Research Volume 85, Issue 4, Cover Image.

Sewda A, White SR, Erazo M, Hao K, García-Fructuoso G, Fernández-Rodriguez I, Heuzé Y, Richtsmeier JT, Romitti PA, Reva B, Jabs EW, Peter I. Nonsyndromic craniosynostosis: novel coding variants. Pediatric Research (2019). PMID:30651579

Ye X, Guilmatre A, Reva B, Peter I, Heuze Y, Richtsmeier JT, Fox DJ, Goedken RJ, Jabs EW, Romitti PA. Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis. Plastic and reconstructive surgery. 2016;137(3):952-61. PMID:26910679

Heuze Y, Holmes G, Peter I, Richtsmeier JT, Jabs EW. Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses. Current genetic medicine reports. 2014;2(3):135-45. PMID:26146596

Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nature Genetics. 2012 Dec;44(12):1360-4. PMID:23160099

Wang Y, Sun M, Uhlhorn VL, Zhou X, Peter I, Martinez-Abadias N, Hill CA, Percival C, Richtsmeier JT, Huso DL, Wang Jabs E. Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+/P253R mice. BMC Developmental Biology. 2010, 10:22. PMID:20175913

Inflammatory Bowel Disease (IBD)

Sabino, J., Torres, J., Colombel, J. F., & Peter, I. (2019). Neonatal Life Events and the Risk of Inflammatory Bowel Disease. Gastroenterology, 157(5), 1440–1441. https://doi.org/10.1053/j.gastro.2019.04.055

Torres, J., & Peter, I. (2019). Neonatal Exposures and Risk of Inflammatory Bowel Disease: When Does the Clock Start Ticking?. Gastroenterology, 157(2), 577–578. https://doi.org/10.1053/j.gastro.2019.06.010

Hu J, Peter I. Evidence of Expression Variation and Allelic Imbalance in Crohn’s Disease Susceptibility Genes NOD2 and ATG16L1 in Human Dendritic Cells. Gene. 2013 Sep 25;527(2):496-502. PMID: 23850724

Zhang W, Hui KY, Gusev A, Warner N, Ng SM, Ferguson J, Choi M, Burberry A, Abraham C, Mayer L, Desnick RJ, Cardinale CJ, Hakonarson H, Waterman M, Chowers Y, Karban A, Brant SR, Silverberg MS, Gregersen PK, Katz S, Lifton RP, Zhao H, Nuñez G, Pe’er I, Peter I, Cho JH. Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3.Genes Immun. 2013 Jul-Aug;14(5):310-6. PMID: 23615072

Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, McGovern DPB, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I. A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci. PLoS Genet, 2012 Mar;8(3):e1002559. PMID:22412388

Peter I, Michell AA, Ozelius L, Erazo M, Hu J, Doehny D, Abrue MT, Present DH, Ullman T, Korelitz B, Mayer L, Desnick RJ and The New York Crohn’s Disease Working Group. Evaluation of 22 Genetic Variants with Crohn’s Disease Risk in the Ashkenazi Jewish Population: a Case-Control Study. BMC Medical Genetics 2011 May 6;12(1):63. PMID:21548950

IBD – Parkinson’s Disease

Link to publications

MECONIUM Study

Link to publications

Microbiome

Torres, J., Hu, J., Seki, A., Eisele, C., Nair, N., Huang, R., Tarassishin, L., Jharap, B., Cote-Daigneault, J., Mao, Q., Mogno, I., Britton, G. J., Uzzan, M., Chen, C. L., Kornbluth, A., George, J., Legnani, P., Maser, E., Loudon, H., Stone, J., … Peter, I. (2020). Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice. Gut, 69(1), 42–51. https://doi.org/10.1136/gutjnl-2018-317855

Hu, J., Ly, J., Zhang, W., Huang, Y., Glover, V., Peter, I., Hurd, Y. L., & Nomura, Y. (2019). Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy. Developmental psychobiology, 61(5), 640–649. https://doi.org/10.1002/dev.21837

Walker, R. W., Clemente, J. C., Peter, I., & Loos, R. J. F. (2017). The prenatal gut microbiome: are we colonized with bacteria in utero?. Pediatric obesity, 12 Suppl 1(Suppl 1), 3–17. https://doi.org/10.1111/ijpo.12217

Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA. Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease. Cell. 2014 Aug 28;158(5):1000-10. PMID:25171403

Hu J, Nomura Y, Bashir A, Fernandez-Hernandez H, Itzkowitz S, Pei Z, Stone J, Loudon H, Peter I. Diversified microbiota of meconium is affected by maternal diabetes status. PLoS One. 2013 Nov 6;8(11):e78257. PMID: 24223144

Genetics of Ashkenazi Jewish Population in Health and Disease

Carmi S, Hui KY, Kochav E, Liu X, Xue J, Grady F, Guha S, Upadhyay K, Ben-Avraham D, Mukherjee S, Bowen BM, Thomas T, Vijai J, Cruts M, Froyen G, Lambrechts D, Plaisance S, Van Broeckhoven C, Van Damme P, Van Marck H, Barzilai N, Darvasi A, Offit K, Bressman S, Ozelius LJ, Peter I, Cho JH, Ostrer H, Atzmon G, Clark LN, Lencz T, Pe’er I. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nat Commun. 2014 Sep 9;5:4835. doi: 10.1038/ncomms5835. PMID:25203624

Vacic V, Ozelius LJ, Clark LN, Bar-Shira A, Gana-Weisz M, Gurevich T, Gusev A, Kedmi M, Kenny EE, Liu X, Mejia-Santana H, Mirelman A, Raymond D, Saunders-Pullman R, Desnick RJ, Atzmon G, Burns ER, Ostrer H, Hakonarson H, Bergman A, Barzilai N, Darvasi A, Peter I, Guha S, Lencz T, Giladi N, Marder K, Pe’er I, Bressman SB, Orr-Urtreger A. Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes. Hum Mol Genet. 2014 Sep 1;23(17):4693-702 PMID:24842889

Selected from over 100 peer-reviewed publications

Obesity, diabetes, and cardiovascular disease

Craniosynostosis

Inflammatory Bowel Disease (IBD)

IBD – Parkinson’s Disease

Link to publications

MECONIUM Study

Link to publications

Microbiome

Genetics of Ashkenazi Jewish Population in Health and Disease

Other topics