Steven Chen is an MD/PhD student studying the contribution of CD103+ dendritic cells to anti-tumor immunity in lung cancer using pooled CRISPR screens. He will also be characterizing the immune landscape of colorectal cancer using single cell RNA-sequencing and CyTOF on patient biopsy samples.
Joel is an MD/PhD student investigating the immune landscape of hepatocellular carcinoma. Leveraging Mt. Sinai’s liver cancer program with access to hundreds of patient samples, as well as single cell platforms such as CyTOF and CITEseq, he endeavors to map the dynamic interplay among immune cells in the tumor microenvironment, and identify potential therapeutic targets. He is particularly interested in learning and developing novel computational methods for analyzing high dimensional, integrated (ie: protein & RNA) data sets.
Ivan is a Fulbright PhD student from Spain developing his thesis in the area of cancer biology and immunology. He did his bachelor in Biotechnology at Pablo de Olavide’s University (Spain) where he conducted research in the field of aging, studying age related gene expression changes in non-coding regulatory RNAs across different organs. He pursued a Master’s degree in Personalized Medicine and Translational Research at the University of Granada (Spain) where he got interested in the field of cancer research and metastasis, basing his master thesis on the characterization of circulating tumor cells in breast and prostate cancer patients using mass cytometry (CyTOF) and digital PCR. He was awarded with a Fulbright fellowship to pursue his PhD studies and joined the Merad Lab where he is currently working on characterizing the heterogeneity of the myeloid compartment in solid tumors as well as the mechanisms by which cancer cells shape the tumor immune microenvironment, thus influencing disease progression and metastasis.
Robert Sweeney, MD
Robby is a clinical thoracic surgery fellow and PhD student in immunology at Mount Sinai with a clinical interest in thoracic malignancies. After completing his general surgery residency at Mount Sinai, Robby joined the laboratories of Sacha Gnjatic and Miriam Merad. In line with his clinical interests, Robby’s project examines the immune microenviroment of early-stage lung cancer and mesothelioma in humans, using single-cell analyses and multiplex imaging to investigate how the tumor microenvironment translates into clinical outcomes and differential responses to immunotherapy. In his spare time, Robby plays classical piano and is a chamber music hobbyist.
Previous research by Dr. Salmon has shown that the extracellular matrix (ECM) associated with established solid tumors influences T cell localization. John’s project aims to better characterize the contribution of cancer-associated fibroblasts (CAFs), a prominent producer of ECM proteins, within the tumor microenvironment. Using early stage human lung tumors, John aims to further our understanding of CAF biology during disease progression and how they influence surrounding immune cells. Through next generation sequencing, imaging, flow cytometry and CyTOF approaches, John will investigate genes/proteins found in different CAF subtypes that will be further explored using in vitro 3D models and validated in in vivo mouse models of lung cancer.
Matthew is an MD/PhD student in the Merad Lab, studying cellular senescence of myeloid cells, in the contexts of aging and tumorigenesis. He completed his bachelor’s degree in biological physics and a program in international affairs at Georgetown University and the Edmund A. Walsh School of Foreign Service. Matthew aims to explore potential mechanisms of metabolic dysregulation and subsequent immune signaling that underscore age-associated pathologies and differential responses to immunotherapy.