Publications from 2025 An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo. Sci Transl Med. from 2024 Alveolar macrophages are early targets of mumps virus. Proc Natl Acad Sci U S A. Immunological landscape of human lymphoid explants during measles virus infection. JCI Insight. Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression. Biomedicines. BTK drives neutrophil activation for sterilizing antifungal immunity. J Clin Invest. from 2023 A Pocket Guide to CCR5-Neurotropic Flavivirus Edition. Viruses. C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection. Cell. Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis. bioRxiv. Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus. Nat Microbiol. from 2022 Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis. J Clin Invest. from 2021 Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem Cell Reports. Zoonotic potential of a novel bat morbillivirus. Res Sq. Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections". Science. The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication. J Virol. Evaluating the Safety of West Nile Virus Immunity During Congenital Zika Virus Infection in Mice. Front Immunol. SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera. mBio. Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity. Immunity. GPER1 is required to protect fetal health from maternal inflammation. Science. 2021 Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. from 2020 SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2. Res Sq [Preprint]. Protective Activity of Programmed Cell Death Protein 1 Blockade and Synergy With Caspofungin in a Murine Invasive Pulmonary Aspergillosis Model. J Infect Dis. Zika virus tropism during early infection of the testicular interstitium and its role in viral pathogenesis in the testes. PLoS Pathog. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell. Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice. Cell Rep. Zika virus envelope nanoparticle antibodies protect mice without risk of disease enhancement. EBioMedicine. from 2019 Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein. J Virol. Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance. Sci Transl Med. Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides. J Virol. Dengue and Zika: The Complexities of Being Related. Trends Immunol. Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation. Pathog Dis. Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy. Immunity. from 2018 CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection. Front Immunol. P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model. J Virol. Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model. Nat Commun. Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and activator of transcription 3 haploinsufficiency. J Allergy Clin Immunol. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection InVitro and in a Mouse Model. mSphere. from 2017 Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology. mBio. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection. mBio. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog. from 2016 Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI Insight. Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. Proc Natl Acad Sci U S A. CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. Sci Transl Med. from 2015 microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection. Cell Host Microbe. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog. γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. J Virol. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans. Infect Immun. from 2014 Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis. Front Cell Neurosci. Long-term survival of influenza virus infected club cells drives immunopathology. J Exp Med. from 2013 CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest. from 2012 The role of chemokines in the pathogenesis of neurotropic flaviviruses. Immunol Res. Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis. PLoS Pathog. from 2011 Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice. Circ Res. Chemokine control of West Nile virus infection. Exp Cell Res. Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. J Immunol. Organ-specific innate immune responses in a mouse model of invasive candidiasis. J Innate Immun.