Past Members

Jakleen Lee
Master’s Student in the Lim Lab: 2018-

Publications from the Lim Lab

  • Hoffman KW,* Lee JJ,* Foster GA, Krysztof D, Stramer SL, and Lim JK. Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation. Pathog Dis. 2019 Mar 1. PMID: 30915442. *equal contribution

Anupa Chokola
Master’s Student in the Lim Lab: 2017-

Publications from the Lim Lab

  • Uzzan M, Tokuyama M, Rosenstein AK,Tomescu C,  SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley AJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, and Mehandru S. Anti-a4b7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals. Sci Transl Med. 2018 Oct 3;10(461). PMID: 30282696.
  • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution

Julia A. Brown, Ph.D.
Ph.D. Student in the Lim Lab: 2017-

Publications from the Lim Lab

  • Tripathi S, Balasubramaniam VR, Brown JA, Mena I, Grant A, Bardina SV, Maringer K, Schwarz MC, Maestre AM, Sourisseau M, Albrecht RA, Krammer F, Evans MJ, Fernandez-Sesma A, Lim JK, García-Sastre A. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog. 2017 Mar 9;13(3):e1006258. PubMed PMID: 28278235.
  • Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017 Apr 14;356(6334):175-180. PubMed PMID: 28360135.
  • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.
  • Jones J, Long K, Whitmore A, Sanders W, Thurlow L, Brown JA, Morrison C, Vincent H, Peck K, Browning C, Moreman N, Lim JK, and Heise M. Disruption of the opal stop codon attenuates chikungunya virus-induced arthralgia and pathology. MBio. 2017 Nov 14;8(6). Pubmed PMID: 29138302.
  • Bailey MJ, Duehr J, Dulin H, Broecker F, Brown JA, Arumemi FO, Bermudez Gonzalez MC, Leyva-Grado VH, Evans MJ, Simon V, Lim JK, Krammer F, Hai R, Palese P, Tan GS. Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model. Nat Commun. 2018 Nov 1;9(1):4560. PMID: 30385750.
  • Soare AY, Durham ND, Gopal R, Tweel B, Hoffman KW, Brown JA, O’Brien M, Bardwaj N, Lim JK, Chen BK, Swartz TH. P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model. J Virol. 2018 Dec 10;93(1). PMID: 30305360.
  • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution
  • Bailey MJ, Broecker F, Freyn AW, Choi A, Brown JA,Fedorova N, Simon V, Lim JK, Evans MJ, Garcia-Sastre A, Palese P, and Tan GS. Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein.  J Virol. 2019 Jun 28;93(14). PMID: 31043537.

Susana Bardina, Ph.D.
Ph.D. Student in the Lim Lab: 2011-2016
Associate Director of Business Development, Hexagon Bio

Publications from the Lim Lab

    • Bardina SV, Lim JK. The role of chemokines in the pathogenesis of neurotropic flaviviruses. Immunol Res. 2012 Dec;54(1-3):121-32. Review. PubMed PMID: 22547394.
    • Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015 Nov 1;195(9):4306-18. PubMed PMID: 26401006.
    • Michlmayr D*, Bardina SV*, Rodriguez CA, Pletnev AG, Lim JK. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. 2016 Jun 1;196(11):4622-31. PubMed PMID: 27183602.*equal contribution
    • Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. PubMed PMID: 27142077.
    • Tripathi S, Balasubramaniam VR, Brown JA, Mena I, Grant A, Bardina SV, Maringer K, Schwarz MC, Maestre AM, Sourisseau M, Albrecht RA, Krammer F, Evans MJ, Fernandez-Sesma A, Lim JK, García-Sastre A. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog. 2017 Mar 9;13(3):e1006258. PubMed PMID: 28278235.
    • Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017 Apr 14;356(6334):175-180. PubMed PMID: 28360135.
    • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.
    • Ford J, Hughson A, LimK, Bardina SV, Lu W, Charo IF, Lim JK, Fowell DJ. CCL7 is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection. Front Immunol.2019 Jan 8;9:3063. PMID: 30671055.

Justin J. Frere
Summer Undergraduate Researcher in the Lim lab: Summer 2016, 2017
Currently an M.D./Ph.D. Student at ISMMS

Publications from the Lim Lab

  • Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017 Apr 14;356(6334):175-180. PubMed PMID: 28360135.
  • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution

Kevin W. Hoffman
M.D./Ph.D. Student in the Lim lab: 2014-2018
Currently an M.D./Ph.D. Student at ISMMS

Publications from the Lim Lab

    • Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015 Nov 1;195(9):4306-18. PubMed PMID: 26401006.
    • Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. PubMed PMID: 27142077.
    • Break TJ, Hoffman KW, Swamydas M, Lee CC, Lim JK, Lionakis MS. Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence. 2016 Oct 2;7(7):826-35. PubMed PMID: 27191829.
    • Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, Drummond RA, Rongkavilit C, Hoffman KW, Henderson C, Clark L, Mezger M, Swamydas M, Engeholm M, Schüle R, Neumayer B, Ebel F, Mikelis CM, Pittaluga S, Prasad VK, Singh A, Milner JD, Williams KW, Lim JK, Kwon-Chung KJ, Holland SM, Hartl D, Kuijpers TW, Lionakis MS. Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI Insight. 2016 Oct 20;1(17):e89890. PubMed PMID: 27777981.
    • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.
    • He W, Chen CJ, Mullarkey C, Hamilton J, Wong C, Leon P, Uccellini M, Chromikova V, Henry C, Hoffman KW, Lim JK, Wilson P, Miller M, Krammer F, Palese P, Tan G. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun. 2017; Oct 10;8(1):846. Pubmed PMID: 29018261.
    • Collar AL, Swamydas M, O’Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS. AThe homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018 Feb 8;3(3). PubMed PMID: 29415879.
    • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution
    • Hoffman KW,* Lee JJ,* Foster GA, Krysztof D, Stramer SL, and Lim JK. Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation. Pathog Dis. 2019 Mar 1. PMID: 30915442. *equal contribution

Silviana Lee
NYU Master’s Student in the Lim lab: Feb 2017-May 2018
Currently an Ph.D. Student at University of Michigan

Publications from the Lim Lab

  • Duehr J, Lee S, Singh G, Foster GA, Krysztof D, Stramer SL, Bermudez Gonzales MC, Menichetti E, Geretschlager R, Gabriel C, Simon V, Lim JK, and Krammer F. Tick-Borne Encephalitis Virus vaccine induced human antibodies mediate negligible enhancement of Zika virus infection in vitro and in a mouse model. mSphere. 2018 Feb 7;3(1). Pubmed PMID: 2935494.
  • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution

Daniela Michlmayr, Ph.D.
Post-Doctoral Fellow in the Lim lab: 2013-2015
Currently a post-doctoral fellow in Eva Harris’s laboratory.

Publications from the Lim Lab

  • Michlmayr D, Lim JK. Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis. Front Cell Neurosci. 2014 Sep 30;8:264. PubMed PMID: 25324719.
  • Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015 Nov 1;195(9):4306-18. PubMed PMID: 26401006
  • Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. PubMed PMID: 27142077.
  • Michlmayr D, Bardina SV, Rodriguez CA, Pletnev AG, Lim JK. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. 2016 Jun 1;196(11):4622-31. PubMed PMID: 27183602.
  • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.

Carlos A. Rodriguez
Laboratory technician in the Lim lab: 2013-2015
Currently a computer software developer at Goldman Sachs

Publications from the Lim Lab

  • Break TJ, Jaeger M, Solis NV, Filler SG, Rodriguez CA, Lim JK, Lee CC, Sobel JD, Netea MG, Lionakis MS. CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans. Infect Immun. 2015 Mar;83(3):958-65. PubMed PMID: 25547797.
  • Long KM, Ferris MT, Whitmore AC, Montgomery SA, Thurlow LR, McGee CE, Rodriguez CA, Lim JK, Heise MT. γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. J Virol. 2015 Oct 21;90(1):433-43. PubMed PMID: 26491151.
  • Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog. 2015 Dec 17;11(12):e1005293. PubMed PMID: 26679537.
  • Swamydas M, Gao JL, Break TJ, Johnson MD, Jaeger M, Rodriguez CA, Lim JK, Green NM, Collar AL, Fischer BG, Lee CC, Perfect JR, Alexander BD, Kullberg BJ, Netea MG, Murphy PM, Lionakis MS. CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. Sci Transl Med. 2016 Jan 20;8(322):322ra10. PubMed PMID: 26791948.
  • Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. PubMed PMID: 27142077.
  • Michlmayr D, Bardina SV, Rodriguez CA, Pletnev AG, Lim JK. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. 2016 Jun 1;196(11):4622-31. PubMed PMID: 27183602.

Janet Sum
Laboratory technician in the Lim lab: 2011-2013
Currently a Project Manager, Icahn School of Medicine at Mount Sinai

Publications from the Lim Lab

  • Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK. Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection. J Immunol. 2015 Nov 1;195(9):4306-18. PubMed PMID: 26401006.
  • Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 Aug 15;214(4):634-43. PubMed PMID: 27142077.
  • Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK. Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. J Virol. 2017 Apr 28;91(10). PubMed PMID: 28356527.

 

Gursewak Singh
Laboratory Technician/Researcher in the Lim lab: 2017-2018
Currently in Ophthalmology School at the University of Massachusetts

Publications from the Lim Lab

  • Duehr J, Lee S, Singh G, Foster GA, Krysztof D, Stramer SL, Bermudez Gonzales MC, Menichetti E, Geretschlager R, Gabriel C, Simon V, Lim JK, and Krammer F. Tick-Borne Encephalitis Virus vaccine induced human antibodies mediate negligible enhancement of Zika virus infection in vitro and in a mouse model. mSphere. 2018 Feb 7;3(1). Pubmed PMID: 29435494.
  • Brown JA*, Singh G*, Acklin JA*, Lee S, Duehr J, Chokola A, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, and Lim JK. Dengue virus immunity increases Zika virus-induced damage during pregnancy. Immunity. 2019 Jan 30. PMID: 30737148. *equal contribution

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