Selected Peer-Reviewed Publications (from over 50 publications)

1.    Liu XH, Kirschenbaum A, Lu M, Yao S, Dosoretz A, Holland JF, and Levine AC.  Prostaglandin E2 induces hypoxia-inducible factor-1a stabilization and nuclear localization in a human prostate cancer cell line.  Journal of Biol. Chem. 277:50081-50086, 2002. PMID:12401798

2.   Liu XH, Kirschenbaum A, Yu K, Yao S, and Levine AC.  Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line.  J Biol. Chem, 280:3817-3813, 2005. PMID:15550400

3.   Liu XH, Kirschenbaum A, Yao S, and Levine AC.  IL-6 and prostaglandin E2 synergistically enhance osteoclastogenesis through effects on the OPG/RANKL/RANK system.  Endocrinology 146 (4):1991-1998, 2005.  PMID:15618359

4.    Kirschenbaum A, Liu XH, Yao S, Narla G, Friedman SL, Martignetti JA, and Levine AC.   Sex steroids have differential effects on growth and gene expression in primary human prostate epithelial cell cultures derived from the peripheral vs. transition zones. Carcinogenesis 27 (2):216-224, 2006. PMID:16123118

5.   Liu XH, Kirschenbaum A, Yao S, and Levine AC.  Interactive Effects of Interluekin-6 and Prostaglandin E2 on Osteoclastogenesis via the OPG/RANKL/RANK System. Ann.N.Y. Acad.Sci 1068:225-233, 2006. PMID:16831922

6.   Liu XH, Kirschenbaum A, Yao S, Aaronson SA, Liu G, and Levine AC.  Androgen-induced Wnt signaling activation in preosteoblasts promotes the growth of MDA-PCA-2b human prostate cancer cells.  Cancer Research 67 (12):5747-53, 2007.  PMID:17575141

7.   Liu XH, Kirschenbaum A, Yao S, Levine AC.  Androgens promote preosteoblast differentiation via activation of the canonical Wnt signaling pathway.  Ann NY Acad Sci 1116:423-431, 2007. PMID:17646262

8.    Chen M, Tanner M, Levine AC, Levina E, Ohouo P, Buttyan R. Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.  Cell Cycle 8(1):149-157, 2009. PMCID:PMC2633936

9.    Xiong S.D., Yu K., Liu X-H, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho S-M, Lam YW and Levine A.C.  Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells.  Int. J. Cancer 125:774-782, 2009. PMID:19384952

10.   Liu X-H, Kirschenbaum A, Weinstein BM, Zaidi M, Yao S, and Levine AC.  Prostaglandin E2 modulates components of the Wnt signaling system in bone and prostate cancer cells.  Biochem and Biophys Res Comm. 394(3):715-720, 2010 PMID:20227393

11.   Zaidi M, Li S, Robinson LJ, Tourkova IL, Liu L, Wang Y, Ling-Ling Z, Li J, Peng Y, Yang G, Sun H, Levine AC, Iqbal J, Yaroslvskiy BB, Isles C, Blair HC.  ACTH protects against glucocorticoid-induced osteonecrosis of bone.  PNAS  May 11:107(19):8782-8787, 2010. PMCID:PMC2889316

12.   Yang W. and Levine AC. “Androgens and Prostate Cancer Bone Metastases: Effects on Both the Seed and the Soil”.  In “Hormones and Cancer: Breast and Prostate”, Elsevier Press, in Special Edition Endocrine Clinics of North America, Sep;40(3):643-53, 2011  PMID:21889726

13.   Kirschenbaum A, Liu X-H, Yao S, Levine AC.  Prostatic acid phosphatase is expressed in human prostate cancer bone metastases and promotes osteoblast differentiation. Ann.N.Y. Acad. Medicine, 1237:64-70, 2011. PMID:22082367

14.   Cannata DH, Kirschenbaum A, Levine AC  Androgen deprivation therapy as primary treatment for prostate cancer.  J. Clin. Endocrinol. Metab. 97(2):360-365, 2012. PMID:22162475

15.   Liu XH, Yong W, Yao S, Levine AC, Kirschenbaum A, Collier L, Bauman WA, Cardozo, CP. Androgens Upregulate Transcription of the Notch Inhibitor Numb in C2C12 Myoblasts via Wnt/beta-catenin Signaling to Tcf Elements in the Numb Promoter. J Biol Chem. 2013 Jun 21;288(25):17990-8. PMID 23649620

16.  Hatami R, Sieuwerts AM, Izadmehr S, Yao Z, Qiao RF, Papa L, Look MP, Smid M, Ohlssen J, Levine AC, Germain D, Burstein D, Kirschenbaum A, DiFeo A, Foekens JA, Narla G. KLF6-SV1 drives breast cancer metastasis and is associated with poor survival. Sci Transl Med. 2013 Jan 23;5(169):169ra12. PMID: 23345610